Aurelia Butler

Currently, there is little research focused on understanding mechanisms and drug discovery of lymphatic vascular diseases. However, conditions such as lymphedema, a buildup of fluid in the body when the lymph system is damaged, impact more than 200,000 people every year in the United States alone.
Dr. Abhishek Jain, assistant professor in the Department of Biomedical Engineering at Texas A&M University, has taken his expertise in organ-on-chip models and applied them to a field they’ve never been used in before, creating the first lymphangion-chip.
To engineer this new device, Jain’s team first developed a new technique to create microfluidic cylindrical blood or lymphatic vessels consisting of endothelial cells, which line blood vessels. It could then use this technique to create a co-cultured multicellular lymphangion, the functional unit of a lymph vessel, and successfully recreate a typical section of a lymphatic transport vessel in vitro, or outside the body.
“We can now better understand how mechanical forces regulate lymphatic physiology and pathophysiology,” Jain said. “We can also understand what are the mechanisms that result in lymphedema, and then we can find new targets for drug discovery with this platform.”
The project is in collaboration with Dr. David Zawieja from the Texas A&M College of Medicine. Their research was published in the Jan. 7 issue of the journal Lab on a Chip.
“Collaborations with Dr. Zawieja and others in the department played a crucial role,” Jain said. “They introduced me to this topic and provide their longstanding expertise that has made it possible for us to create this new organ-on-chip platform and now advance it in these exciting directions using contemporary experimental models.”
Jain said the impact of this work is far-reaching because there is a new hope for patients with lymphatic diseases. They can now learn about the biology of these diseases and reach a point where they can be treated.
“The most exciting part of this research is that it is allowing us to now push the organ-on-chip in directions where finding cures for rare and orphan (understudied) diseases is possible with less effort and money,” Jain said. “We can help the pharma industry to invest in this platform and find a cure for lymphedema that impacts millions of people.”
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Materials provided by Texas A&M University. Original written by Jennifer Reiley. Note: Content may be edited for style and length. More

The ability to interact with light provides important functionalities for quantum systems, such as communicating over large distances, a key ability for future quantum computers. However, it is very difficult to find a material that can fully exploit the quantum properties of light. A research team from the CNRS and l’Université de Strasbourg, with support from Chimie ParisTech-PSL1 and in collaboration with German teams from KIT2, has demonstrated the potential of a new material based on rare earths as a photonic quantum system. The results, which were published on 9 March 2022 in Nature, show the interest of europium molecular crystals for quantum memories and computers.
While quantum technologies promise a revolution in the future, they still remain complex to put in place. For example, quantum systems that can interact with light to create processing functionalities for information and communication through fibre optics in particular, remain rare. Such a platform3 must ideally include an interface with light as well as information storage units, which is to say a memory. Information processing must also be possible within these units, which take the form of spin4. Developing materials that enable a link between spins and light on the quantum level has proven especially difficult.
A team of scientists from the CNRS and l’Université de Strasbourg, with support from Chimie ParisTech-PSL and in collaboration with German teams from KIT, has successfully demonstrated the value of europium molecular crystals5 for quantum communications and processors, thanks to their ultra-narrow optical transitions enabling optimal interactions with light.
These crystals are the combined product of two systems already used in quantum technology: rare earth ions (such as europium), and molecular systems. Rare-earth crystals are known for their excellent optical and spin properties, but their integration in photonic devices is complex. Molecular systems generally lack spins (a storage or computing unit), or on the contrary present optical lines that are too broad to establish a reliable link between spins and light.
Europium molecular crystals represent a major advance, as they have ultra-narrow linewidths. This translates into long-lived quantum states, which were used to demonstrate the storage of a light pulse inside these molecular crystals. Moreover, a first building block for a quantum computer controlled by light has been obtained. This new material for quantum technologies offers previously unseen properties, and paves the way for new architectures for computers and quantum memories in which light will play a central role.
The results also open broad prospects for research thanks to the many molecular compounds that can be synthesized.
Notes
1 — Scientists from the following laboratories participated: the Institut de recherche de chimie Paris (CNRS/Chimie ParisTech-PSL), the Institut de physique et chimie des matériaux de Strasbourg (CNRS/Université de Strasbourg), Institut de science et d’ingénierie supramoléculaire (CNRS/Université de Strasbourg), and the Centre européen de sciences quantiques.
2 — Karlsruher Institute of Technology (KIT) including the Institute of Quantum Materials and Technology (IQMT), the Institute of Nanotechnology (INT) and the Physikalishes Institut (PHI) in Germany, also participated
3 — A platform refers to a multifunctional quantum material.
4 — Spin is one of the properties of particles, along with mass and electric charge, which determines their behaviour in a magnetic field.
5 — Molecular crystals are perfectly ordered stacks of individual molecules.
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A collaborative study led by the University of Wollongong confirms switching mechanism for a new, proposed generation of ultra-low energy ‘topological electronics’.
Based on novel quantum topological materials, such devices would ‘switch’ a topological insulator from non-conducting (conventional electrical insulator) to a conducting (topological insulator) state, whereby electrical current could flow along its edge states without wasted dissipation of energy.
Such topological electronics could radically reduce the energy consumed in computing and electronics, which is estimated to consume 8% of global electricity, and doubling every decade.
Led by Dr Muhammad Nadeem at the University of Wollongong (UOW), the study also brought in expertise from FLEET Centre collaborators at UNSW and Monash University.
Resolving the Switching Challenge, and Introducing the Tqfet
Two-dimensional topological insulators are promising materials for topological quantum electronic devices where edge state transport can be controlled by a gate-induced electric field. More

How can Einstein’s theory of gravity be unified with quantum mechanics? It is a challenge that could give us deep insights into phenomena such as black holes and the birth of the universe. Now, a new article in Nature Communications, written by researchers from Chalmers University of Technology, Sweden, and MIT, USA, presents results that cast new light on important challenges in understanding quantum gravity.
A grand challenge in modern theoretical physics is to find a ‘unified theory’ that can describe all the laws of nature within a single framework — connecting Einstein’s general theory of relativity, which describes the universe on a large scale, and quantum mechanics, which describes our world at the atomic level. Such a theory of ‘quantum gravity’ would include both a macroscopic and microscopic description of nature.
“We strive to understand the laws of nature and the language in which these are written is mathematics. When we seek answers to questions in physics, we are often led to new discoveries in mathematics too. This interaction is particularly prominent in the search for quantum gravity — where it is extremely difficult to perform experiments,” explains Daniel Persson, Professor at the Department of Mathematical Sciences at Chalmers university of technology.
An example of a phenomenon that requires this type of unified description is black holes. A black hole forms when a sufficiently heavy star expands and collapses under its own gravitational force, so that all its mass is concentrated in an extremely small volume. The quantum mechanical description of black holes is still in its infancy but involves spectacular advanced mathematics.
A simplified model for quantum gravity
“The challenge is to describe how gravity arises as an ’emergent’ phenomenon. Just as everyday phenomena — such as the flow of a liquid — emerge from the chaotic movements of individual droplets, we want to describe how gravity emerges from quantum mechanical system at the microscopic level,” says Robert Berman, Professor at the Department of Mathematical Sciences at Chalmers University of Technology. More

The information age created over nearly 60 years has given the world the internet, smart phones and lightning-fast computers. Making this possible has been the doubling of the number of transistors that can be packed onto a computer chip roughly every two years, giving rise to billions of atomic-scale transistors that now fit on a fingernail-sized chip. Such “atomic scale” lengths are so tiny that individual atoms can be seen and counted in them.
Physical limit
With this doubling now rapidly approaching a physical limit, the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) has joined industry efforts to extend the process and develop new ways to produce ever-more capable, efficient, and cost-effective chips. Laboratory scientists have now accurately predicted through modeling a key step in atomic-scale chip fabrication in the first PPPL study under a Cooperative Research and Development Agreement (CRADA) with Lam Research Corp., a world-wide supplier of chip-making equipment.
“This would be one little piece in the whole process,” said David Graves, associate laboratory director for low-temperature plasma surface interactions, a professor in the Princeton Department of Chemical and Biological Engineering and co-author of a paper that outlines the findings in the Journal of Vacuum Science & Technology B. Insights gained through modeling, he said, “can lead to all sorts of good things, and that’s why this effort at the Lab has got some promise.”
While the shrinkage can’t go on much longer, “it hasn’t completely reached an end,” he said. “Industry has been successful to date in using mainly empirical methods to develop innovative new processes but a deeper fundamental understanding will speed this process. Fundamental studies take time and require expertise industry does not always have,” he said. “This creates a strong incentive for laboratories to take on the work.”
The PPPL scientists modeled what is called “atomic layer etching” (ALE), an increasingly critical fabrication step that aims to remove single atomic layers from a surface at a time. This process can be used to etch complex three-dimensional structures with critical dimensions that are thousands of times thinner than a human hair into a film on a silicon wafer.
Basic agreement
“The simulations basically agreed with experiments as a first step and could lead to improved understanding of the use of ALE for atomic-scale etching,” said Joseph Vella, a post-doctoral fellow at PPPL and lead author of the journal paper. Improved understanding will enable PPPL to investigate such things as the extent of surface damage and the degree of roughness developed during ALE, he said, “and this all starts with building our fundamental understanding of atomic layer etching.”
The model simulated the sequential use of chlorine gas and argon plasma ions to control the silicon etch process on an atomic scale. Plasma, or ionized gas, is a mixture consisting of free electrons, positively charged ions and neutral molecules. The plasma used in semiconductor device processing is near room temperature, in contrast to the ultra-hot plasma used in fusion experiments.
“A surprise empirical finding from Lam Research was that the ALE process became particularly effective when the ion energies were quite a bit higher than the ones we started with,” Graves said. “So that will be our next step in the simulations — to see if we can understand what’s happening when the ion energy is much higher and why it’s so good.”
Going forward, “the semiconductor industry as a whole is contemplating a major expansion in the materials and the types of devices to be used, and this expansion will also have to be processed with atomic scale precision,” he said. “The U.S. goal is to lead the world in using science to tackle important industrial problems,” he said, “and our work is part of that.”
This study was partially supported by the DOE Office of Science. Coauthors included David Humbird of DWH Consulting in Centennial, Colorado.
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Materials provided by DOE/Princeton Plasma Physics Laboratory. Original written by John Greenwald. Note: Content may be edited for style and length. More

From chatbots that answer tax questions to algorithms that drive autonomous vehicles and dish out medical diagnoses, artificial intelligence undergirds many aspects of daily life. Creating smarter, more accurate systems requires a hybrid human-machine approach, according to researchers at the University of California, Irvine. In a study published this month in Proceedings of the National Academy of Sciences, they present a new mathematical model that can improve performance by combining human and algorithmic predictions and confidence scores.
“Humans and machine algorithms have complementary strengths and weaknesses. Each uses different sources of information and strategies to make predictions and decisions,” said co-author Mark Steyvers, UCI professor of cognitive sciences. “We show through empirical demonstrations as well as theoretical analyses that humans can improve the predictions of AI even when human accuracy is somewhat below [that of] the AI — and vice versa. And this accuracy is higher than combining predictions from two individuals or two AI algorithms.”
To test the framework, researchers conducted an image classification experiment in which human participants and computer algorithms worked separately to correctly identify distorted pictures of animals and everyday items — chairs, bottles, bicycles, trucks. The human participants ranked their confidence in the accuracy of each image identification as low, medium or high, while the machine classifier generated a continuous score. The results showed large differences in confidence between humans and AI algorithms across images.
“In some cases, human participants were quite confident that a particular picture contained a chair, for example, while the AI algorithm was confused about the image,” said co-author Padhraic Smyth, UCI Chancellor’s Professor of computer science. “Similarly, for other images, the AI algorithm was able to confidently provide a label for the object shown, while human participants were unsure if the distorted picture contained any recognizable object.”
When predictions and confidence scores from both were combined using the researchers’ new Bayesian framework, the hybrid model led to better performance than either human or machine predictions achieved alone.
“While past research has demonstrated the benefits of combining machine predictions or combining human predictions — the so-called ‘wisdom of the crowds’ — this work forges a new direction in demonstrating the potential of combining human and machine predictions, pointing to new and improved approaches to human-AI collaboration,” Smyth said.
This interdisciplinary project was facilitated by the Irvine Initiative in AI, Law, and Society. The convergence of cognitive sciences — which are focused on understanding how humans think and behave — with computer science — in which technologies are produced — will provide further insight into how humans and machines can collaborate to build more accurate artificially intelligent systems, the researchers said.
Additional co-authors include Heliodoro Tejada, a UCI graduate student in cognitive sciences, and Gavin Kerrigan, a UCI Ph.D. student in computer science.
Funding for this study was provided by the National Science Foundation under award numbers 1927245 and 1900644 and the HPI Research Center in Machine Learning and Data Science at UCI.
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Legal documents, such as contracts or deeds, are notoriously difficult for nonlawyers to understand. A new study from MIT cognitive scientists has determined just why these documents are often so impenetrable.
After analyzing thousands of legal contracts and comparing them to other types of texts, the researchers found that lawyers have a habit of frequently inserting long definitions in the middle of sentences. Linguists have previously demonstrated that this type of structure, known as “center-embedding,” makes text much more difficult to understand.
While center-embedding had the most significant effect on comprehension difficulty, the MIT study found that the use of unnecessary jargon also contributes.
“It’s not a secret that legal language is very hard to understand. It’s borderline incomprehensible a lot of the time,” says Edward Gibson, an MIT professor of brain and cognitive sciences and the senior author of the new paper. “In this study, we’re documenting in detail what the problem is.”
The researchers hope that their findings will lead to greater awareness of this issue and stimulate efforts to make legal documents more accessible to the general public.
“Making legal language more straightforward would help people understand their rights and obligations better, and therefore be less susceptible to being unnecessarily punished or not being able to benefit from their entitled rights,” says Eric Martinez, a recent law school graduate and licensed attorney who is now a graduate student in brain and cognitive sciences at MIT. More

On the big screen, in video games and in our imaginations, lightsabers flare and catch when they clash together. In reality, as in a laser light show, the beams of light go through each other, creating spiderweb patterns. That clashing, or interference, happens only in fiction — and in places with enormous magnetic and electric fields, which happens in nature only near massive objects such as neutron stars. Here, the strong magnetic or electric field reveals that vacuum isn’t truly a void. Instead, here when light beams intersect, they scatter into rainbows.
A weak version of this effect has been observed in modern particle accelerators, but it is completely absent from our daily lives or even normal laboratory environments.
Yuli Lyanda-Geller, professor of physics and astronomy in the College of Science at Purdue University, in collaboration with Aydin Keser and Oleg Sushkov from the University of New South Wales in Australia, discovered that it is possible to produce this effect in a class of novel materials involving bismuth, its solid solutions with antimony and tantalum arsenide.
With this knowledge, the effect can be studied, potentially leading to vastly more sensitive sensors as well as supercapacitors for energy storage that could be turned on and off by a controlled magnetic field.
“Most importantly, one of the deepest quantum mysteries in the universe can be tested and studied in a small laboratory experiment,” Lyanda-Geller said. “With these materials, we can study effects of the universe. We can study what happens in neutron stars from our laboratories.”
Brief summary of methods
Keser, Lyanda-Geller and Sushkov applied quantum field theory nonperturbative methods used to describe high-energy particles and expanded them to analyze the behavior of so-called Dirac materials, which recently became the focus of interest. They used the expansion to obtain results that go both beyond known high-energy results and the general framework of condensed matter and materials physics. They suggested various experimental configurations with applied electric and magnetic fields and analyzed best materials that would allow them to experimentally study this quantum electrodynamic effect in a nonaccelerator setting.
They subsequently discovered that their results better explained some magnetic phenomena that had been observed and studied in earlier experiments.
Funding
U.S. Department of Energy, Office of Basic Energy Sciences; Division of Materials Sciences and Engineering; and the Australian Research Council, Centre of Excellence in Future Low Energy Electronics Technologies
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Materials provided by Purdue University. Original written by Brittany Steff. Note: Content may be edited for style and length. More