Aurelia Butler

The invasive mosquitofish (Gambusia holbrooki) chews off the tails of freshwater fishes and tadpoles, leaving the native animals to perish while dining on other fishes’ and amphibians’ eggs. In a study published December 16 in the journal iScience, researchers engineered a robot to scare mosquitofish away, revealing how fear alters its behavior, physiology, fertility — and may help turn the tide against invasive species.
To fight the invasive fish, the international team, composed of biologists and engineers from Australia, the U.S., and Italy, turned to its natural predator — the largemouth bass (Micropterus salmoides) — for inspiration. They crafted a robotic fish that mimics the appearance and simulates the movements of the real predator. Aided by computer vision, the robot strikes when it spots the mosquitofish approaching tadpoles of an Australian species (Litoria moorei), which is threatened by mosquitofish in the wild. Scared and stressed, the mosquitofish showed fearful behaviors and experienced weight loss, changes in body shape, and a reduction in fertility, all of which impair their survival and reproduction.
“Mosquitofish is one of the 100 world’s worst invasive species, and current methods to eradicate it are too expensive and time-consuming to effectively contrast its spread,” says first author Giovanni Polverino (@GioPolverino) of the University of Western Australia. “This global pest is a serious threat to many aquatic animals. Instead of killing them one by one, we’re presenting an approach that can inform better strategies to control this global pest. We made their worst nightmare become real: a robot that scares the mosquitofish but not the other animals around it.”
In the presence of the robotic fish, mosquitofish tended to stay closer to each other and spend more time at the center of the testing arena, hesitant to tread uncharted waters. They also swam more frenetically, with frequent and sharp turns, than those who haven’t met the robot. Away from the robot and back in their home aquaria, the effect of fear lasted. The scared fish were less active, ate more, and froze longer, presenting signs of anxiety that continued weeks after their last encounter with the robot.
For the tadpoles the mosquitofish usually prey on, the robot’s presence was a change for the better. While the mosquitofish is a visual animal that surveys the environment mainly through its eyes, tadpoles have poor eyesight: they don’t see the robot well. “We expected the robot to have neutral effects on the tadpoles, but that wasn’t the case,” says Polverino. Because the robot changed the behavior of the mosquitofish, the tadpoles didn’t have predators at their tails anymore and they were more willing to venture out in the testing arena. “It turned out to be a positive thing for tadpoles. Once freed from the danger of having mosquitofish around, they were not scared anymore. They’re happy.”
After five weeks of brief encounters between the mosquitofish and the robot, the team found that the fish allocated more energy towards escaping than reproducing. Male fish’s bodies became thin and streamlined with stronger muscles near the tail, built to cut through the water for fleeing. Male fish also had lower sperm counts while females produced lighter eggs, which are changes that are likely to compromise the species’ survival as a whole.
“While successful at thwarting mosquitofish, the lab-grown robotic fish is not ready to be released into the wild,” says senior author Maurizio Porfiri of New York University. The team will still have to overcome technical challenges. As a first step, they plan to test the method on small, clear pools in Australia, where two endangered fish are threatened by mosquitofish.
“Invasive species are a huge problem worldwide and are the second cause for the loss of biodiversity,” says Polverino. “Hopefully, our approach of using robotics to reveal the weaknesses of an incredibly successful pest will open the door to improve our biocontrol practices and combat invasive species. We are very excited about this.”
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Artificial intelligence can predict which people who attend memory clinics will develop dementia within two years with 92 per cent accuracy, a largescale new study has concluded.
Using data from more than 15,300 patients in the US, research from the University of Exeter found that a form of artificial intelligence called machine learning can accurately tell who will go on to develop dementia.
The technique works by spotting hidden patterns in the data and learning who is most at risk. The study, published in JAMA Network Open and funded by funded by Alzheimer’s Research UK, also suggested that the algorithm could help reduce the number of people who may have been falsely diagnosed with dementia.
The researchers analysed data from people who attended a network of 30 National Alzheimer’s Coordinating Center memory clinics in the US. The attendees did not have dementia at the start of the study, though many were experiencing problems with memory or other brain functions.
In the study timeframe between 2005 and 2015, one in ten attendees (1,568) received a new diagnosis of dementia within two years of visiting the memory clinic. The research found that the machine learning model could predict these new dementia cases with up to 92 per cent accuracy — and far more accurately than two existing alternative research methods.
The researchers also found for the first time that around eight per cent (130) of the dementia diagnoses appeared to be made in error, as their diagnosis was subsequently reversed. Machine learning models accurately identified more than 80 per cent of these inconsistent diagnoses. Artificial intelligence can not only accurately predict who will be diagnosed with dementia, it also has the potential to improve the accuracy of these diagnoses.
Professor David Llewellyn, an Alan Turing Fellow based at the University of Exeter, who oversaw the study, said: “We’re now able to teach computers to accurately predict who will go on to develop dementia within two years. We’re also excited to learn that our machine learning approach was able to identify patients who may have been misdiagnosed. This has the potential to reduce the guesswork in clinical practice and significantly improve the diagnostic pathway, helping families access the support they need as swiftly and as accurately as possible.”
Dr Janice Ranson, Research Fellow at the University of Exeter added “We know that dementia is a highly feared condition. Embedding machine learning in memory clinics could help ensure diagnosis is far more accurate, reducing the unnecessary distress that a wrong diagnosis could cause.”
The researchers found that machine learning works efficiently, using patient information routinely available in clinic, such as memory and brain function, performance on cognitive tests and specific lifestyle factors. The team now plans to conduct follow-up studies to evaluate the practical use of the machine learning method in clinics, to assess whether it can be rolled out to improve dementia diagnosis, treatment and care.
Dr Rosa Sancho, Head of Research at Alzheimer’s Research UK said “Artificial intelligence has huge potential for improving early detection of the diseases that cause dementia and could revolutionise the diagnosis process for people concerned about themselves or a loved one showing symptoms. This technique is a significant improvement over existing alternative approaches and could give doctors a basis for recommending life-style changes and identifying people who might benefit from support or in-depth assessments.”
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Unlike the jumble of frequencies produced by the light that surrounds us in daily life, each frequency of light in a specialized light source known as a “soliton” frequency comb oscillates in unison, generating solitary pulses with consistent timing.
Each “tooth” of the comb is a different color of light, spaced so precisely that this system is used to measure all manner of phenomena and characteristics. Miniaturized versions of these combs — called microcombs — that are currently in development have the potential to enhance countless technologies, including GPS systems, telecommunications, autonomous vehicles, greenhouse gas tracking, spacecraft autonomy and ultra-precise timekeeping.
The lab of Stanford University electrical engineer Jelena Vučković only recently joined the microcomb community. “Many groups have demonstrated on-chip frequency combs in a variety of materials, including recently in silicon carbide by our team. However, until now, the quantum optical properties of frequency combs have been elusive,” said Vučković, the Jensen Huang Professor of Global Leadership in the School of Engineering and professor of electrical engineering at Stanford. “We wanted to leverage the quantum optics background of our group to study the quantum properties of the soliton microcomb.”
While soliton microcombs have been made in other labs, the Stanford researchers are among the first to investigate the system’s quantum optical properties, using a process that they outline in a paper published Dec. 16 in Nature Photonics. When created in pairs, microcomb solitons are thought to exhibit entanglement — a relationship between particles that allows them to influence each other even at incredible distances, which underpins our understanding of quantum physics and is the basis of all proposed quantum technologies. Most of the “classical” light we encounter on a daily basis does not exhibit entanglement.
“This is one of the first demonstrations that this miniaturized frequency comb can generate interesting quantum light — non-classical light — on a chip,” said Kiyoul Yang, a research scientist in Vučković’s Nanoscale and Quantum Photonics Lab and co-author of the paper. “That can open a new pathway toward broader explorations of quantum light using the frequency comb and photonic integrated circuits for large-scale experiments.”
Proving the utility of their tool, the researchers also provided convincing evidence of quantum entanglement within the soliton microcomb, which has been theorized and assumed but has yet to be proven by any existing studies. More

Amorphous oxide semiconductors (AOS) are a promising option for the next generation of display technologies due to their low costs and high electron (charge carrier) mobility. The high mobility, in particular, is essential for high-speed images. But AOSs also have a distinct drawback that is hampering their commercialization — the mobility-stability tradeoff.
One of the core tests of stability in TFTs is the “negative-bias temperature stress” (NBTS) stability test. Two AOS TFTs of interest are indium gallium zinc oxide (IGZO) and indium tin zinc oxide (ITZO). IGZO TFTs have high NBTS stability but poor mobility while ITZO TFTs have the opposite characteristics. The existence of this tradeoff is well-known, but thus far there has been no understanding of why it occurs.
In a recent study published in Nature Electronics, a team of scientists from Japan have now reported a solution to this tradeoff. “In our study, we focused on NBTS stability which is conventionally explained using ‘charge trapping.’ This describes the loss of accumulated charge into the underlying substrate. However, we doubted if this could explain the differences we see in IGZO and ITZO TFTs, so instead we focused on the possibility of a change in carrier density or Fermi level shift in the AOS itself,” explains Assistant Professor Junghwan Kim of Tokyo Tech, who headed the study.
To investigate the NBTS stability, the team used a “bottom-gate TFT with a bilayer active-channel structure” comprising an NBTS-stable AOS (IGZO) layer and an NBTS-unstable AOS (ITZO) layer. They then characterized the TFT and compared the results with device simulations performed using the charge-trapping and the Fermi-level shift models.
They found that the experimental data agreed with the Fermi-level shift model. “Once we had this information, the next question was, ‘What is the major factor controlling mobility in AOSs?'” says Prof. Kim.
The fabrication of AOS TFTs introduces impurities, including carbon monoxide (CO), into the TFT, especially in the ITZO case. The team found that charge transfer was occurring between the AOSs and the unintended impurities. In this case the CO impurities were donating electrons into the active layer of the TFT, which caused the Fermi-level shift and NBTS instability. “The mechanism of this CO-based electron donation is dependent on the location of the conduction band minimum, which is why you see it in high-mobility TFTs such as ITZO but not in IGZO,” elaborates Prof. Kim.
Armed with this knowledge, the researchers developed an ITZO TFT without CO impurities by treating the TFT at 400°C and found that it was NBTS stable. “Super-high vision technologies need TFTs with an electron mobility above 40 cm2 (Vs)-1. By eliminating the CO impurities, we were able to fabricate an ITZO TFT with a mobility as high as 70 cm2 (Vs)-1,” comments an excited Prof. Kim.
However, CO impurities alone do not cause instability. “Any impurity that induces a charge transfer with AOSs can cause gate-bias instability. To achieve high-mobility oxide TFTs, we need contributions from the industrial side to clarify all possible origins for impurities,” asserts Prof. Kim.
The results could pave the way for fabrication of other similar AOS TFTs for use in display technologies, as well as chip input/output devices, image sensors and power systems. Moreover, given their low cost, they might even replace more expensive silicon-based technologies.
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Team’s findings could help the design of industrially relevant quantum materials for sensing, computing and communication.
“Vacancy” is a sign you want to see when searching for a hotel room on a road trip. When it comes to quantum materials, vacancies are also something you want to see. Scientists create them by removing atoms in crystalline materials. Such vacancies can serve as quantum bits or qubits, the basic unit of quantum technology.
Researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory and the University of Chicago have made a breakthrough that should help pave the way for greatly improved control over the formation of vacancies in silicon carbide, a semiconductor.
Semiconductors are the material behind the brains in cell phones, computers, medical equipment and more. For those applications, the existence of atomic-scale defects in the form of vacancies is undesirable, as they can interfere with performance. According to recent studies, however, certain types of vacancies in silicon carbide and other semiconductors show promise for the realization of qubits in quantum devices. Applications of qubits could include unhackable communication networks and hypersensitive sensors able to detect individual molecules or cells. Also possible in the future are new types of computers able to solve complex problems beyond the reach of classical computers.
“Scientists already know how to produce qubit-worthy vacancies in semiconductors such as silicon carbide and diamond,” said Giulia Galli, a senior scientist at Argonne’s Materials Science Division and professor of molecular engineering and chemistry at the University of Chicago. ?”But for practical new quantum applications, they still need to know much more about how to customize these vacancies with desired features.”
In silicon carbide semiconductors, single vacancies occur upon the removal of individual silicon and carbon atoms in the crystal lattice. Importantly, a carbon vacancy can pair with an adjacent silicon vacancy. This paired vacancy, called a divacancy, is a key candidate as a qubit in silicon carbide. The problem has been that the yield for converting single vacancies into divacancies has been low, a few percent. Scientists are racing to develop a pathway to increase that yield. More

Across a vast array of robotic hands and clamps, there is a common foe: the heirloom tomato. You may have seen a robotic gripper deftly pluck an egg or smoothly palm a basketball — but, unlike human hands, one gripper is unlikely to be able to do both and a key challenge remains hidden in the middle ground.
“You’ll see robotic hands do a power grasp and a precision grasp and then kind of imply that they can do everything in between,” said Wilson Ruotolo, PhD ’21, a former graduate student in the Biomimetics and Dextrous Manipulation Lab at Stanford University. “What we wanted to address is how to create manipulators that are both dexterous and strong at the same time.”
The result of this goal is “farmHand,” a robotic hand developed by engineers Ruotolo and Dane Brouwer, a graduate student in the Biomimetics and Dextrous Manipulation Lab, at Stanford (aka “the Farm”) and detailed in a paper published Dec. 15 in Science Robotics. In their testing, the researchers demonstrated that farmHand is capable of handling a wide variety of items, including raw eggs, bunches of grapes, plates, jugs of liquids, basketballs and even an angle grinder.
FarmHand benefits from two kinds of biological inspiration. While the multi-jointed fingers are reminiscent of a human hand — albeit a four-fingered one — the fingers are topped with gecko-inspired adhesives. This grippy but not sticky material is based on the structure of gecko toes and has been developed over the last decade by the Biomimetics and Dextrous Manipulation Lab, led by Mark Cutkosky, the Fletcher Jones Professor in the School of Engineering, who is also senior author of this research.
Using the gecko-adhesive on a multi-fingered, anthropomorphic gripper for the first time was a challenge, which required special attention to the tendons controlling the fingers of farmHand and the design of the finger pads below the adhesive.
From the Farm to space and back again
Like gecko’s toes, the gecko adhesive creates a strong hold via microscopic flaps. When in full contact with a surface, these flaps create a Van der Waals force — a weak intermolecular force that results from subtle differences in the positions of electrons on the outsides of molecules. As a result, the adhesives can grip strongly but require little actual force to do so. Another bonus: they don’t feel sticky to the touch or leave a residue behind. More

Searching for molecules that could act as effective therapies for devastating diseases requires extensive time, money and resources — and it often ends in failure.
Researchers at the USC Dornsife College of Letters, Arts and Sciences have created a process that increases the chances of finding effective drugs in a fraction of the time and at significantly less expense than current methods of drug discovery.
The research was published Dec. 15 in the journal Nature.
Puzzling together new, effective drug therapies
Scientists working to create new drugs are equal parts puzzle-solvers and construction workers.
Having peered into a cell and identified a protein that, if manipulated, could help ease or avoid disease, they search for chemical molecules with a specific shape and size, as well as the right features, to fit a target pocket on that protein. More