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    A newfound quasicrystal formed in the first atomic bomb test

    In an instant, the bomb obliterated everything.

    The tower it sat on and the copper wires strung around it: vaporized. The desert sand below: melted.

    In the aftermath of the first test of an atomic bomb, in July 1945, all this debris fused together, leaving the ground of the New Mexico test site coated with a glassy substance now called trinitite. High temperatures and pressures helped forge an unusual structure within one piece of trinitite, in a grain of the material just 10 micrometers across — a bit longer than a red blood cell.

    That grain contains a rare form of matter called a quasicrystal, born the moment the nuclear age began, scientists report May 17 in Proceedings of the National Academy of Sciences.

    Normal crystals are made of atoms locked in a lattice that repeats in a regular pattern. Quasicrystals have a structure that is orderly like a normal crystal but that doesn’t repeat. This means quasicrystals can have properties that are forbidden for normal crystals. First discovered in the lab in 1980s, quasicrystals also appear in nature in meteorites (SN: 12/8/16).

    Penrose tilings (one shown) are an example of a structure that is ordered but does not repeat. Quasicrystals are a three-dimensional version of this idea.Inductiveload/Wikimedia Commons

    The newly discovered quasicrystal from the New Mexico test site is the oldest one known that was made by humans.

    Trinitite takes its moniker from the nuclear test, named Trinity, in which the material was created in abundance (SN: 4/8/21). “You can still buy lots of it on eBay,” says geophysicist Terry Wallace, a coauthor of the study and emeritus director of Los Alamos National Laboratory in New Mexico.

    But, he notes, the trinitite the team studied was a rarer variety, called red trinitite. Most trinitite has a greenish tinge, but red trinitite contains copper, remnants of the wires that stretched from the ground to the bomb. Quasicrystals tend to be found in materials that have experienced a violent impact and usually involve metals. Red trinitite fit both criteria.

    But first the team had to find some.

    “I was asking around for months looking for red trinitite,” says theoretical physicist Paul Steinhardt of Princeton University. But Steinhardt, who is known for trekking to Siberia to seek out quasicrystals, wasn’t deterred (SN: 2/19/19). Eventually he and his colleagues got some from an expert in trinitite who began collaborating with the team. Then, the painstaking work started, “looking through every little microscopic speck” of the trinitite sample, says Steinhardt. Finally, the researchers extracted the tiny grain. By scattering X-rays through it, the researchers revealed that the material had a type of symmetry found only in quasicrystals.

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    The new quasicrystal, formed of silicon, copper, calcium and iron, is “brand new to science,” says mineralogist Chi Ma of Caltech, who was not involved with the study. “It’s a quite cool and exciting discovery,” he says.

    Future searches for quasicrystals could examine other materials that experienced a punishing blow, such as impact craters or fulgurites, fused structures formed when lightning strikes soil (SN: 3/16/21).

    The study shows that artifacts from the birth of the atomic age are still of scientific interest, says materials scientist Miriam Hiebert of the University of Maryland in College Park, who has analyzed materials from other pivotal moments in nuclear history (SN: 5/1/19). “Historic objects and materials are not just curiosities in collectors’ cabinets but can be of real scientific value,” she says. More

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    Archaeologists teach computers to sort ancient pottery

    Archaeologists at Northern Arizona University are hoping a new technology they helped pioneer will change the way scientists study the broken pieces left behind by ancient societies.
    The team from NAU’s Department of Anthropology have succeeded in teaching computers to perform a complex task many scientists who study ancient societies have long dreamt of: rapidly and consistently sorting thousands of pottery designs into multiple stylistic categories. By using a form of machine learning known as Convolutional Neural Networks (CNNs), the archaeologists created a computerized method that roughly emulates the thought processes of the human mind in analyzing visual information.
    “Now, using digital photographs of pottery, computers can accomplish what used to involve hundreds of hours of tedious, painstaking and eye-straining work by archaeologists who physically sorted pieces of broken pottery into groups, in a fraction of the time and with greater consistency,” said Leszek Pawlowicz, adjunct faculty in the Department of Anthropology. He and anthropology professor Chris Downum began researching the feasibility of using a computer to accurately classify broken pieces of pottery, known as sherds, into known pottery types in 2016. Results of their research are reported in the June issue of the peer-reviewed publication Journal of Archaeological Science.
    “On many of the thousands of archaeological sites scattered across the American Southwest, archaeologists will often find broken fragments of pottery known as sherds. Many of these sherds will have designs that can be sorted into previously-defined stylistic categories, called ‘types,’ that have been correlated with both the general time period they were manufactured and the locations where they were made” Downum said. “These provide archaeologists with critical information about the time a site was occupied, the cultural group with which it was associated and other groups with whom they interacted.”
    The research relied on recent breakthroughs in the use of machine learning to classify images by type, specifically CNNs. CNNs are now a mainstay in computer image recognition, being used for everything from X-ray images for medical conditions and matching images in search engines to self-driving cars. Pawlowicz and Downum reasoned that if CNNs can be used to identify things like breeds of dogs and products a consumer might like, why not apply this approach to the analysis of ancient pottery?
    Until now, the process of recognizing diagnostic design features on pottery has been difficult and time-consuming. It could involve months or years of training to master and correctly apply the design categories to tiny pieces of a broken pot. Worse, the process was prone to human error because expert archaeologists often disagree over which type is represented by a sherd, and might find it difficult to express their decision-making process in words. An anonymous peer reviewer of the article called this “the dirty secret in archaeology that no one talks about enough.”
    Determined to create a more efficient process, Pawlowicz and Downum gathered thousands of pictures of pottery fragments with a specific set of identifying physical characteristics, known as Tusayan White Ware, common across much of northeast Arizona and nearby states. They then recruited four of the Southwest’s top pottery experts to identify the pottery design type for every sherd and create a ‘training set’ of sherds from which the machine can learn. Finally, they trained the machine to learn pottery types by focusing on the pottery specimens the archaeologists agreed on. More

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    Algorithm to see inside materials with subatomic particles

    The University of Kent’s School of Physical Sciences, in collaboration with the Science and Technology Facilities Council (STFC) and the Universities of Cardiff, Durham and Leeds, have developed an algorithm to train computers to analyse signals from subatomic particles embedded in advanced electronic materials.
    The particles, called muons, are produced in large particle accelerators and are implanted inside samples of materials in order to investigate their magnetic properties. Muons are uniquely useful as they couple magnetically to individual atoms inside the material and then emit a signal detectable by researchers to obtain information on that magnetism.
    This ability to examine magnetism on the atomic scale makes muon-based measurements one of the most powerful probes of magnetism in electronic materials, including “quantum materials” such as superconductors and other exotic forms of matter.
    As it is not possible to deduce what is going on in the material by simple examination of the signal, researchers normally compare their data to generic models. In contrast, the present team adapted a data-science technique called Principal Component Analysis (PCA), frequently employed in Face Recognition.
    The PCA technique involves a computer being fed many related but distinct images and then running an algorithm identifying a small number “archetypal” images that can be combined to reproduce, with great accuracy, any of the original images. An algorithm trained in this way can then go on to perform tasks such as recognising whether a new image matches a previously-seen one.
    Researchers adapted the PCA technique to analyse the signals sent out by muons embedded in complex materials, training the algorithm for a variety of quantum materials using experimental data obtained at the ISIS Neutron and Muon source of the STFC Rutherford Appleton Laboratory.
    The results showed the new technique is equally as proficient as the standard method at detecting phase transitions and in some cases could detect transitions beyond the capabilities of standard analyses.
    Dr Jorge Quintanilla, Senior Lecturer in Condensed Matter Theory at Kent and leader of the Physics of Quantum Materials research group said: ‘Our research results are exceptional, as this was achieved by an algorithm that knew nothing about the physics of the materials being investigated. This suggests that the new approach might have very broad application and, as such, we have made our algorithms available for use by the worldwide research community.’
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    Materials provided by University of Kent. Original written by Sam Wood. Note: Content may be edited for style and length. More

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    Future sparkles for diamond-based quantum technology

    Marilyn Monroe famously sang that diamonds are a girl’s best friend, but they are also very popular with quantum scientists — with two new research breakthroughs poised to accelerate the development of synthetic diamond-based quantum technology, improve scalability, and dramatically reduce manufacturing costs.
    While silicon is traditionally used for computer and mobile phone hardware, diamond has unique properties that make it particularly useful as a base for emerging quantum technologies such as quantum supercomputers, secure communications and sensors.
    However there are two key problems; cost, and difficulty in fabricating the single crystal diamond layer, which is smaller than one millionth of a metre.
    A research team from the ARC Centre of Excellence for Transformative Meta-Optics at the University of Technology Sydney (UTS), led by Professor Igor Aharonovich, has just published two research papers, in Nanoscale and Advanced Quantum Technologies, that address these challenges.
    “For diamond to be used in quantum applications, we need to precisely engineer ‘optical defects’ in the diamond devices — cavities and waveguides — to control, manipulate and readout information in the form of qubits — the quantum version of classical computer bits,” said Professor Aharonovich.
    “It’s akin to cutting holes or carving gullies in a super thin sheet of diamond, to ensure light travels and bounces in the desired direction,” he said. More

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    Virtual reality warps your sense of time

    Psychology researchers at UC Santa Cruz have found that playing games in virtual reality creates an effect called “time compression,” where time goes by faster than you think. Grayson Mullen, who was a cognitive science undergraduate at the time, worked with Psychology Professor Nicolas Davidenko to design an experiment that tested how virtual reality’s effects on a game player’s sense of time differ from those of conventional monitors. The results are now published in the journal Timing & Time Perception.
    Mullen designed a maze game that could be played in both virtual reality and conventional formats, then the research team recruited 41 UC Santa Cruz undergraduate students to test the game. Participants played in both formats, with researchers randomizing which version of the game each student started with. Both versions were essentially the same, but the mazes in each varied slightly so that there was no repetition between formats.
    Participants were asked to stop playing the game whenever they felt like five minutes had passed. Since there were no clocks available, each person had to make this estimate based on their own perception of the passage of time.
    Prior studies of time perception in virtual reality have often asked participants about their experiences after the fact, but in this experiment, the research team wanted to integrate a time-keeping task into the virtual reality experience in order to capture what was happening in the moment. Researchers recorded the actual amount of time that had passed when each participant stopped playing the game, and this revealed a gap between participants’ perception of time and the reality.
    The study found that participants who played the virtual reality version of the game first played for an average of 72.6 seconds longer before feeling that five minutes had passed than students who started on a conventional monitor. In other words, students played for 28.5 percent more time than they realized in virtual reality, compared to conventional formats.
    This time compression effect was observed only among participants who played the game in virtual reality first. The paper concluded this was because participants based their judgement of time in the second round on whatever initial time estimates they made during the first round, regardless of format. But if the time compression observed in the first round is translatable to other types of virtual reality experiences and longer time intervals, it could be a big step forward in understanding how this effect works. More

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    The U.S.’s first open-air genetically modified mosquitoes have taken flight

    The first genetically modified mosquitoes that will be allowed to fly free outdoors in the United States have started reaching the age for mating in the Florida Keys.

    In a test of the biotech company Oxitec’s GM male mosquitoes for pest control, these Aedes aegypti started growing from tiny eggs set out in toaster-sized, hexagonal boxes on suburban private properties in late April. On May 12, experiment monitors confirmed that males had matured enough to start flying off on their own to court American female mosquitoes.

    This short-term Florida experiment marks the first outdoor test in the United States of a strain of GM male mosquitoes as a highly targeted pest control strategy. This strain is engineered to shrink local populations of Ae. aegypti, a mosquito species that spreads dengue and Zika (SN: 7/29/16). That could start happening now that the GM mosquitoes have reached mating age because their genetics makes them such terrible choices as dads.

    The mosquitoes now waving distinctively masculine (extra fluffy) antennae in Florida carry genetic add-ons that block development in females. No female larvae should survive to adulthood in the wild, says molecular biologist Nathan Rose, Oxitec’s chief of regulatory affairs. Half the released males’ sons, however, will carry dad’s daughter-killing trait. The sons of the bad dads can go on to trick a new generation of females into unwise mating decisions and doomed daughters (SN: 1/8/09).

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    The trait is not designed to last in an area’s mosquitoes, though. The genetics just follow the same old rules of natural inheritance that mosquitoes and people follow: Traits pass to some offspring and not others. Only half a bad dad’s sons will carry the daughter-killing trait. The others will sire normal mosquito families.

    Imagined versions of live-mosquito pest control in Florida have been both glorified and savaged in spirited community meetings for some time (SN: 8/22/20). But now it’s real. “I’m sure you can understand why we’re so excited,” said Andrea Leal, executive director of the Florida Keys Mosquito Control District, at the mosquito test (virtual) kickoff April 29.

    The debate over these transgenic Ae. aegypti mosquitoes has gone on so long that Oxitec has upgraded its original more coddled version with one that is essentially plug and play. The newer strain, dubbed OX5034, no longer needs a breeding colony with its (biting) females and antibiotics in easy reach of the release area to produce fresh males.

    Instead, Oxitec can just ship eggs in a phase of suspended development from its home base in Abingdon, England, to whatever location around the world, high-tech or not, wants to deploy them. Brazil has already tested this OX5034 strain and gone through the regulatory process to permit Oxitec to sell it there.

    The targets for these potential living pest controls will be just their own kind. They represent only about 4 percent of the combined populations of the 45 or so mosquito species whining around the Keys. Other species get annoying, and a more recent invader, Ae. albopictus, can also spread dengue and Zika to some extent. Yet Leal blames just about all the current human disease spread by mosquitoes in the Keys, including last year’s dengue outbreak, on Ae. aegypti.

    It’s one of the top three mosquitoes in the world in the number of diseases it can spread, says Don Yee, an aquatic ecologist at the University of Southern Mississippi in Hattiesburg, who studies mosquitoes (SN: 3/31/21). His lab has linked at least three dozen human pathogens, including some viruses and worms, to Ae. aegypti. Although most mosquitoes lurk outdoors in vegetation, this one loves humankind. In the tropics, “the adults are literally resting on the walls or the ceiling,” he says. “They’re hanging around the bathroom.” The species bites humans for more than half of its blood meals.

    In a long-running battle with this beast, staff in Florida in late April added water to boxes of shipped eggs and set them out at selected suburban private properties on Vaca, Cudjoe and Ramrod Keys. Other spots, with no added mosquitoes, will be watched as controls. All locations were chosen in part because American-hatched females of the same species were already there to be wooed, Rose says.

    Toaster-sized hexagonal boxes (one pictured) that contain eggs of genetically modified Aedes aegypti were set out on selected private property in the Keys in late April. There the males develop normally — and then fly away to mate.Oxitec

    Males typically don’t billow out of their boxes in a gray cloud but emerge sporadically, a few at a time. If all goes well in this preliminary test, up to 12,000 GM mosquitoes in total across the release sites will take to the air each week for 12 weeks.

    Neighboring households will host mosquito traps to monitor how far from the nursery boxes the Oxitec GM males tend to fly. That’s data that the U.S. Environmental Protection Agency wants to see. Based on distance tests elsewhere, 50 meters might be the median, Rose estimates. 

    The distance matters because pest controllers want to keep the free-flying GM mosquitoes away from outdoor sources of the antibiotic tetracycline. That’s the substance the genetic engineers use as an off switch for the self-destruct mechanism in female larvae. Rearing facilities supply the antibiotic to larvae, turning off the lethal genetics and letting females survive in a lab to lay eggs for the next generation.

    If GM males loosed in Florida happened to breed with a female that lays eggs in some puddle of water laced with the right concentration of tetracycline, daughters that inherited the switch could survive to adulthood as biters and breeders. The main possible sources in the Keys would be sewage treatment plants, Rose says. The test designers say they have selected sites well away from them.

    After the distance tests, bigger releases still start looking at how well males fare and whether pest numbers shrink. Up to 20 million Oxitec mosquitoes in total could be released in tests running into the fall.

    Despite some high-profile protests, finding people to host the boxes was not hard, Rose says. “We were oversubscribed.” At public hearings, the critics of the project typically outshout the fans. Yet there’s also support. In a 2016 nonbinding referendum on using GM mosquitoes, 31 of 33 precincts in Monroe County, which comprises the Keys, voted yes for the test release. Twenty of those victories were competitive though, not reaching 60 percent.

    The males being released rely on a live-sons/dead-daughters strategy. That’s a change from the earlier strain of Oxitec mosquitoes. Those males sabotaged all offspring regardless of sex. The change came during the genetic redesign that permits an egg-shipping strategy. Surviving sons, however, mean the nonengineered genes in the new Oxitec strain can mix into the Florida population more than in the original version.

    Those mixed-in genes from the test are “unlikely” to strengthen Floridian mosquitoes’ powers to spread disease, researchers from the EPA and the U.S. Centers for Disease Control and Prevention wrote in a May 1, 2020 memorandum. Many factors besides mosquito genetics affect how a disease spreads, the reviewers noted. Oxitec will be monitoring for mixing.

    There may be at least one upside to mixing, Rose says. The lab colonies have little resistance to some common pesticides such as permethrin that the Floridian mosquitoes barely seem to notice.

    Pesticide resistance in the Keys is what drives a lot of the interest in GM techniques, says chemist Phil Goodman, who chairs the local mosquito control district’s board of commissioners. During the dengue outbreak in 2009 and 2010, the first one in decades, the district discovered that its spray program had just about zero effect on Ae. aegypti. With some rethinking of the program’s chemicals, the control district can now wipe out up to 50 percent of mosquitoes of this species in a treated area. That’s not great control, at best. Then when bad weather intervenes for days in a row, the mosquitoes rebound, Goodman says.

    The invasive mosquito species Aedes aegypti (shown), which can spread Zika, dengue and yellow fever, is now under attack in the Florida Keys by GM males genetically tweaked to sabotage the American mosquito populations.Joao Paulo Burini/Moment/Getty Images Plus

    Since that 2009–2010 outbreak, catching dengue in Florida instead of just through foreign travel has become more common. In 2020, an unusually bad year for dengue, Florida reported 70 cases caught locally, according to the CDC’s provisional tally. 

    Traditional pesticides can mess with creatures besides their pest targets, and some critics of the GMO mosquitoes also worry about unexpected ecological effects. Yet success of the Oxitec mosquitoes in slamming the current pests should not cause some disastrous shortage of food or pollination for natives, Yee says. Ae. aegypti invaded North America within the past four centuries, probably too short a time to become absolutely necessary for some native North American predator or plant.

    For more details on pretrial tests and data, the Mosquito Control District has now posted a swarm of documents about the GM mosquitoes. The EPA’s summary of Oxitec’s tests, for instance, reports no effects noticed for feeding the aquatic mosquito larvae to crawfish.

    Yee doesn’t worry much about either crustaceans or fish eating the larvae. “That’s somewhat analogous to saying, well, we’re concerned about releasing buffalo back into the prairies of the Midwest because they might get eaten by lions,” he says. Crawfish and fish, he notes, don’t naturally inhabit the small containers of still water where Ae. aegypti mosquitoes breed.

    Still, new mosquito-fighting options are springing up: Radiation techniques might become precise enough to sterilize males but leave them attractive enough to fool females into pointless mating. And researchers are developing other genetic ways to weaponize mosquitoes against their own kind.

    One technique that uses no GM wizardry just infects mosquitoes with Wolbachia bacteria that make biting unlikely to spread dengue. The latest data from Mexico and Columbia suggest this infection “could be effective in the southern U.S. and across the Caribbean,” says biologist Scott O’Neil, based in Ho Chi Minh City, Vietnam, founder of the World Mosquito Program.

    He has no plans for working in the United States but is instead focusing on places with much worse dengue problems. His version of the Wolbachia strategy just makes bites less dangerous (SN: 6/29/12). The mosquito population doesn’t shrink or grow less bloodthirsty, so this approach might not appeal to Floridians anyway. More

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    A sibling-guided strategy to capture the 3D shape of the human face

    A new strategy for capturing the 3D shape of the human face draws on data from sibling pairs and leads to identification of novel links between facial shape traits and specific locations within the human genome. Hanne Hoskens of the Department of Human Genetics at Katholieke Universiteit in Leuven, Belgium, and colleagues present these findings in the open-access journal PLOS Genetics.
    The ability to capture the 3D shape of the human face — and how it varies between individuals with different genetics — can inform a variety of applications, including understanding human evolution, planning for surgery, and forensic sciences. However, existing tools for linking genetics to physical traits require input of simple measurements, such as distance between the eyes, that do not adequately capture the complexities of facial shape.
    Now, Hoskens and colleagues have developed a new strategy for capturing these complexities in a format that can then be studied with existing analytical tools. To do so, they drew on the facial similarities often seen between genetically related siblings. The strategy was initially developed by learning from 3D facial data from a group of 273 pairs of siblings of European ancestry, which revealed 1,048 facial traits that are shared between siblings — and therefore presumably have a genetic basis.
    The researchers then applied their new strategy for capturing face shape to 8,246 individuals of European ancestry, for whom they also had genetic information. This produced data on face-shape similarities between siblings that could then be combined with their genetic data and analyzed with existing tools for linking genetics to physical traits. Doing so revealed 218 locations within the human genome, or loci, that were associated with facial traits shared by siblings.
    Further examination of the 218 loci showed that some are the sites of genes that have previously been linked to embryonic facial development and abnormal development of head and facial bones.
    The authors note that this study could serve as the basis for several different directions of future research, including replication of the findings in larger populations, and investigation of the identified genetic loci in order to better understand the biological processes involved in facial development.
    Hoskens adds, “Since siblings are likely to share facial features due to close kinship, traits that are biologically relevant can be extracted from phenotypically similar sibling pairs.”
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    Making AI algorithms show their work

    Artificial intelligence (AI) learning machines can be trained to solve problems and puzzles on their own instead of using rules that we made for them. But often, researchers do not know what rules the machines make for themselves. Cold Spring Harbor Laboratory (CSHL) Assistant Professor Peter Koo developed a new method that quizzes a machine-learning program to figure out what rules it learned on its own and if they are the right ones.
    Computer scientists “train” an AI machine to make predictions by presenting it with a set of data. The machine extracts a series of rules and operations — a model — based on information it encountered during its training. Koo says:
    “If you learn general rules about the math instead of memorizing the equations, you know how to solve those equations. So rather than just memorizing those equations, we hope that these models are learning to solve it and now we can give it any equation and it will solve it.”
    Koo developed a type of AI called a deep neural network (DNN) to look for patterns in RNA strands that increase the ability of a protein to bind to them. Koo trained his DNN, called Residual Bind (RB), with thousands of RNA sequences matched to protein binding scores, and RB became good at predicting scores for new RNA sequences. But Koo did not know whether the machine was focusing on a short sequence of RNA letters — a motif — that humans might expect, or some other secondary characteristic of the RNA strands that they might not.
    Koo and his team developed a new method, called Global Importance Analysis, to test what rules RB generated to make its predictions. He presented the trained network with a carefully designed set of synthetic RNA sequences containing different combinations of motifs and features that the scientists thought might influence RB’s assessments.
    They discovered the network considered more than just the spelling of a short motif. It factored in how the RNA strand might fold over and bind to itself, how close one motif is to another, and other features.
    Koo hopes to test some key results in a laboratory. But rather than test every prediction in that lab, Koo’s new method acts like a virtual lab. Researchers can design and test millions of different variables computationally, far more than humans could test in a real-world lab.
    “Biology is super anecdotal. You can find a sequence, you can find a pattern but you don’t know ‘Is that pattern really important?’ You have to do these interventional experiments. In this case, all my experiments are all done by just asking the neural network.”
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    Materials provided by Cold Spring Harbor Laboratory. Original written by Luis Sandoval. Note: Content may be edited for style and length. More