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    Virtual reality warps your sense of time

    Psychology researchers at UC Santa Cruz have found that playing games in virtual reality creates an effect called “time compression,” where time goes by faster than you think. Grayson Mullen, who was a cognitive science undergraduate at the time, worked with Psychology Professor Nicolas Davidenko to design an experiment that tested how virtual reality’s effects on a game player’s sense of time differ from those of conventional monitors. The results are now published in the journal Timing & Time Perception.
    Mullen designed a maze game that could be played in both virtual reality and conventional formats, then the research team recruited 41 UC Santa Cruz undergraduate students to test the game. Participants played in both formats, with researchers randomizing which version of the game each student started with. Both versions were essentially the same, but the mazes in each varied slightly so that there was no repetition between formats.
    Participants were asked to stop playing the game whenever they felt like five minutes had passed. Since there were no clocks available, each person had to make this estimate based on their own perception of the passage of time.
    Prior studies of time perception in virtual reality have often asked participants about their experiences after the fact, but in this experiment, the research team wanted to integrate a time-keeping task into the virtual reality experience in order to capture what was happening in the moment. Researchers recorded the actual amount of time that had passed when each participant stopped playing the game, and this revealed a gap between participants’ perception of time and the reality.
    The study found that participants who played the virtual reality version of the game first played for an average of 72.6 seconds longer before feeling that five minutes had passed than students who started on a conventional monitor. In other words, students played for 28.5 percent more time than they realized in virtual reality, compared to conventional formats.
    This time compression effect was observed only among participants who played the game in virtual reality first. The paper concluded this was because participants based their judgement of time in the second round on whatever initial time estimates they made during the first round, regardless of format. But if the time compression observed in the first round is translatable to other types of virtual reality experiences and longer time intervals, it could be a big step forward in understanding how this effect works. More

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    The U.S.’s first open-air genetically modified mosquitoes have taken flight

    The first genetically modified mosquitoes that will be allowed to fly free outdoors in the United States have started reaching the age for mating in the Florida Keys.

    In a test of the biotech company Oxitec’s GM male mosquitoes for pest control, these Aedes aegypti started growing from tiny eggs set out in toaster-sized, hexagonal boxes on suburban private properties in late April. On May 12, experiment monitors confirmed that males had matured enough to start flying off on their own to court American female mosquitoes.

    This short-term Florida experiment marks the first outdoor test in the United States of a strain of GM male mosquitoes as a highly targeted pest control strategy. This strain is engineered to shrink local populations of Ae. aegypti, a mosquito species that spreads dengue and Zika (SN: 7/29/16). That could start happening now that the GM mosquitoes have reached mating age because their genetics makes them such terrible choices as dads.

    The mosquitoes now waving distinctively masculine (extra fluffy) antennae in Florida carry genetic add-ons that block development in females. No female larvae should survive to adulthood in the wild, says molecular biologist Nathan Rose, Oxitec’s chief of regulatory affairs. Half the released males’ sons, however, will carry dad’s daughter-killing trait. The sons of the bad dads can go on to trick a new generation of females into unwise mating decisions and doomed daughters (SN: 1/8/09).

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    The trait is not designed to last in an area’s mosquitoes, though. The genetics just follow the same old rules of natural inheritance that mosquitoes and people follow: Traits pass to some offspring and not others. Only half a bad dad’s sons will carry the daughter-killing trait. The others will sire normal mosquito families.

    Imagined versions of live-mosquito pest control in Florida have been both glorified and savaged in spirited community meetings for some time (SN: 8/22/20). But now it’s real. “I’m sure you can understand why we’re so excited,” said Andrea Leal, executive director of the Florida Keys Mosquito Control District, at the mosquito test (virtual) kickoff April 29.

    The debate over these transgenic Ae. aegypti mosquitoes has gone on so long that Oxitec has upgraded its original more coddled version with one that is essentially plug and play. The newer strain, dubbed OX5034, no longer needs a breeding colony with its (biting) females and antibiotics in easy reach of the release area to produce fresh males.

    Instead, Oxitec can just ship eggs in a phase of suspended development from its home base in Abingdon, England, to whatever location around the world, high-tech or not, wants to deploy them. Brazil has already tested this OX5034 strain and gone through the regulatory process to permit Oxitec to sell it there.

    The targets for these potential living pest controls will be just their own kind. They represent only about 4 percent of the combined populations of the 45 or so mosquito species whining around the Keys. Other species get annoying, and a more recent invader, Ae. albopictus, can also spread dengue and Zika to some extent. Yet Leal blames just about all the current human disease spread by mosquitoes in the Keys, including last year’s dengue outbreak, on Ae. aegypti.

    It’s one of the top three mosquitoes in the world in the number of diseases it can spread, says Don Yee, an aquatic ecologist at the University of Southern Mississippi in Hattiesburg, who studies mosquitoes (SN: 3/31/21). His lab has linked at least three dozen human pathogens, including some viruses and worms, to Ae. aegypti. Although most mosquitoes lurk outdoors in vegetation, this one loves humankind. In the tropics, “the adults are literally resting on the walls or the ceiling,” he says. “They’re hanging around the bathroom.” The species bites humans for more than half of its blood meals.

    In a long-running battle with this beast, staff in Florida in late April added water to boxes of shipped eggs and set them out at selected suburban private properties on Vaca, Cudjoe and Ramrod Keys. Other spots, with no added mosquitoes, will be watched as controls. All locations were chosen in part because American-hatched females of the same species were already there to be wooed, Rose says.

    Toaster-sized hexagonal boxes (one pictured) that contain eggs of genetically modified Aedes aegypti were set out on selected private property in the Keys in late April. There the males develop normally — and then fly away to mate.Oxitec

    Males typically don’t billow out of their boxes in a gray cloud but emerge sporadically, a few at a time. If all goes well in this preliminary test, up to 12,000 GM mosquitoes in total across the release sites will take to the air each week for 12 weeks.

    Neighboring households will host mosquito traps to monitor how far from the nursery boxes the Oxitec GM males tend to fly. That’s data that the U.S. Environmental Protection Agency wants to see. Based on distance tests elsewhere, 50 meters might be the median, Rose estimates. 

    The distance matters because pest controllers want to keep the free-flying GM mosquitoes away from outdoor sources of the antibiotic tetracycline. That’s the substance the genetic engineers use as an off switch for the self-destruct mechanism in female larvae. Rearing facilities supply the antibiotic to larvae, turning off the lethal genetics and letting females survive in a lab to lay eggs for the next generation.

    If GM males loosed in Florida happened to breed with a female that lays eggs in some puddle of water laced with the right concentration of tetracycline, daughters that inherited the switch could survive to adulthood as biters and breeders. The main possible sources in the Keys would be sewage treatment plants, Rose says. The test designers say they have selected sites well away from them.

    After the distance tests, bigger releases still start looking at how well males fare and whether pest numbers shrink. Up to 20 million Oxitec mosquitoes in total could be released in tests running into the fall.

    Despite some high-profile protests, finding people to host the boxes was not hard, Rose says. “We were oversubscribed.” At public hearings, the critics of the project typically outshout the fans. Yet there’s also support. In a 2016 nonbinding referendum on using GM mosquitoes, 31 of 33 precincts in Monroe County, which comprises the Keys, voted yes for the test release. Twenty of those victories were competitive though, not reaching 60 percent.

    The males being released rely on a live-sons/dead-daughters strategy. That’s a change from the earlier strain of Oxitec mosquitoes. Those males sabotaged all offspring regardless of sex. The change came during the genetic redesign that permits an egg-shipping strategy. Surviving sons, however, mean the nonengineered genes in the new Oxitec strain can mix into the Florida population more than in the original version.

    Those mixed-in genes from the test are “unlikely” to strengthen Floridian mosquitoes’ powers to spread disease, researchers from the EPA and the U.S. Centers for Disease Control and Prevention wrote in a May 1, 2020 memorandum. Many factors besides mosquito genetics affect how a disease spreads, the reviewers noted. Oxitec will be monitoring for mixing.

    There may be at least one upside to mixing, Rose says. The lab colonies have little resistance to some common pesticides such as permethrin that the Floridian mosquitoes barely seem to notice.

    Pesticide resistance in the Keys is what drives a lot of the interest in GM techniques, says chemist Phil Goodman, who chairs the local mosquito control district’s board of commissioners. During the dengue outbreak in 2009 and 2010, the first one in decades, the district discovered that its spray program had just about zero effect on Ae. aegypti. With some rethinking of the program’s chemicals, the control district can now wipe out up to 50 percent of mosquitoes of this species in a treated area. That’s not great control, at best. Then when bad weather intervenes for days in a row, the mosquitoes rebound, Goodman says.

    The invasive mosquito species Aedes aegypti (shown), which can spread Zika, dengue and yellow fever, is now under attack in the Florida Keys by GM males genetically tweaked to sabotage the American mosquito populations.Joao Paulo Burini/Moment/Getty Images Plus

    Since that 2009–2010 outbreak, catching dengue in Florida instead of just through foreign travel has become more common. In 2020, an unusually bad year for dengue, Florida reported 70 cases caught locally, according to the CDC’s provisional tally. 

    Traditional pesticides can mess with creatures besides their pest targets, and some critics of the GMO mosquitoes also worry about unexpected ecological effects. Yet success of the Oxitec mosquitoes in slamming the current pests should not cause some disastrous shortage of food or pollination for natives, Yee says. Ae. aegypti invaded North America within the past four centuries, probably too short a time to become absolutely necessary for some native North American predator or plant.

    For more details on pretrial tests and data, the Mosquito Control District has now posted a swarm of documents about the GM mosquitoes. The EPA’s summary of Oxitec’s tests, for instance, reports no effects noticed for feeding the aquatic mosquito larvae to crawfish.

    Yee doesn’t worry much about either crustaceans or fish eating the larvae. “That’s somewhat analogous to saying, well, we’re concerned about releasing buffalo back into the prairies of the Midwest because they might get eaten by lions,” he says. Crawfish and fish, he notes, don’t naturally inhabit the small containers of still water where Ae. aegypti mosquitoes breed.

    Still, new mosquito-fighting options are springing up: Radiation techniques might become precise enough to sterilize males but leave them attractive enough to fool females into pointless mating. And researchers are developing other genetic ways to weaponize mosquitoes against their own kind.

    One technique that uses no GM wizardry just infects mosquitoes with Wolbachia bacteria that make biting unlikely to spread dengue. The latest data from Mexico and Columbia suggest this infection “could be effective in the southern U.S. and across the Caribbean,” says biologist Scott O’Neil, based in Ho Chi Minh City, Vietnam, founder of the World Mosquito Program.

    He has no plans for working in the United States but is instead focusing on places with much worse dengue problems. His version of the Wolbachia strategy just makes bites less dangerous (SN: 6/29/12). The mosquito population doesn’t shrink or grow less bloodthirsty, so this approach might not appeal to Floridians anyway. More

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    A sibling-guided strategy to capture the 3D shape of the human face

    A new strategy for capturing the 3D shape of the human face draws on data from sibling pairs and leads to identification of novel links between facial shape traits and specific locations within the human genome. Hanne Hoskens of the Department of Human Genetics at Katholieke Universiteit in Leuven, Belgium, and colleagues present these findings in the open-access journal PLOS Genetics.
    The ability to capture the 3D shape of the human face — and how it varies between individuals with different genetics — can inform a variety of applications, including understanding human evolution, planning for surgery, and forensic sciences. However, existing tools for linking genetics to physical traits require input of simple measurements, such as distance between the eyes, that do not adequately capture the complexities of facial shape.
    Now, Hoskens and colleagues have developed a new strategy for capturing these complexities in a format that can then be studied with existing analytical tools. To do so, they drew on the facial similarities often seen between genetically related siblings. The strategy was initially developed by learning from 3D facial data from a group of 273 pairs of siblings of European ancestry, which revealed 1,048 facial traits that are shared between siblings — and therefore presumably have a genetic basis.
    The researchers then applied their new strategy for capturing face shape to 8,246 individuals of European ancestry, for whom they also had genetic information. This produced data on face-shape similarities between siblings that could then be combined with their genetic data and analyzed with existing tools for linking genetics to physical traits. Doing so revealed 218 locations within the human genome, or loci, that were associated with facial traits shared by siblings.
    Further examination of the 218 loci showed that some are the sites of genes that have previously been linked to embryonic facial development and abnormal development of head and facial bones.
    The authors note that this study could serve as the basis for several different directions of future research, including replication of the findings in larger populations, and investigation of the identified genetic loci in order to better understand the biological processes involved in facial development.
    Hoskens adds, “Since siblings are likely to share facial features due to close kinship, traits that are biologically relevant can be extracted from phenotypically similar sibling pairs.”
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    Making AI algorithms show their work

    Artificial intelligence (AI) learning machines can be trained to solve problems and puzzles on their own instead of using rules that we made for them. But often, researchers do not know what rules the machines make for themselves. Cold Spring Harbor Laboratory (CSHL) Assistant Professor Peter Koo developed a new method that quizzes a machine-learning program to figure out what rules it learned on its own and if they are the right ones.
    Computer scientists “train” an AI machine to make predictions by presenting it with a set of data. The machine extracts a series of rules and operations — a model — based on information it encountered during its training. Koo says:
    “If you learn general rules about the math instead of memorizing the equations, you know how to solve those equations. So rather than just memorizing those equations, we hope that these models are learning to solve it and now we can give it any equation and it will solve it.”
    Koo developed a type of AI called a deep neural network (DNN) to look for patterns in RNA strands that increase the ability of a protein to bind to them. Koo trained his DNN, called Residual Bind (RB), with thousands of RNA sequences matched to protein binding scores, and RB became good at predicting scores for new RNA sequences. But Koo did not know whether the machine was focusing on a short sequence of RNA letters — a motif — that humans might expect, or some other secondary characteristic of the RNA strands that they might not.
    Koo and his team developed a new method, called Global Importance Analysis, to test what rules RB generated to make its predictions. He presented the trained network with a carefully designed set of synthetic RNA sequences containing different combinations of motifs and features that the scientists thought might influence RB’s assessments.
    They discovered the network considered more than just the spelling of a short motif. It factored in how the RNA strand might fold over and bind to itself, how close one motif is to another, and other features.
    Koo hopes to test some key results in a laboratory. But rather than test every prediction in that lab, Koo’s new method acts like a virtual lab. Researchers can design and test millions of different variables computationally, far more than humans could test in a real-world lab.
    “Biology is super anecdotal. You can find a sequence, you can find a pattern but you don’t know ‘Is that pattern really important?’ You have to do these interventional experiments. In this case, all my experiments are all done by just asking the neural network.”
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    Materials provided by Cold Spring Harbor Laboratory. Original written by Luis Sandoval. Note: Content may be edited for style and length. More

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    Rivers might not be as resilient to drought as once thought

    Rivers ravaged by a lengthy drought may not be able to recover, even after the rains return. Seven years after the Millennium drought baked southeastern Australia, a large fraction of the region’s rivers still show no signs of returning to their predrought water flow, researchers report in the May 14 Science.

    There’s “an implicit assumption that no matter how big a disturbance is, the water will always come back — it’s just a matter of how long it takes,” says Tim Peterson, a hydrologist at Monash University in Melbourne, Australia. “I’ve never been satisfied with that.”

    The years-long drought in southeastern Australia, which began sometime between 1997 and 2001 and lasted until 2010, offered a natural experiment to test this assumption, he says. “It wasn’t the most severe drought” the region has ever experienced, but it was the longest period of low rainfall in the region since about 1900.

    Peterson and colleagues analyzed annual and seasonal streamflow rates in 161 river basins in the region from before, during and after the drought. By 2017, they found, 37 percent of those river basins still weren’t seeing the amount of water flow that they had predrought. Furthermore, of those low-flow rivers, the vast majority — 80 percent — also show no signs that they might recover in the future, the team found.

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    Many of southeastern Australia’s rivers had bounced back from previous droughts, including a severe but brief episode in 1983. But even heavy rains in 2010, marking the end of the Millennium drought, weren’t enough to return these basins to their earlier state. That suggests that there is, after all, a limit to rivers’ resilience.

    What’s changed in these river basins isn’t yet clear, Peterson says. The precipitation post drought was similar to predrought precipitation, and the water isn’t ending up in the streamflow, so it must be going somewhere else. The team examined various possibilities: The water infiltrated into the ground and was stored as groundwater, or it never made it to the ground at all — possibly intercepted by leaves, and then evaporating back to the air.

    But none of these explanations were borne out by studies of these sites, the researchers report. The remaining, and most probable, possibility is that the environment has changed: Water is evaporating from soils and transpiring from plants more quickly than it did predrought.

    Peterson has long suggested that under certain conditions rivers might not, in fact, recover — and this study confirms that theoretical work, says Peter Troch, a hydrologist at the University of Arizona in Tucson. Enhanced soil evaporation and plant transpiration are examples of such positive feedbacks, processes that can enhance the impacts of a drought. “Until his work, this lack of resilience was not anticipated, and all hydrological models did not account for such possibility,” Troch says.

    “This study will definitely inspire other researchers to undertake such work,” he notes. “Hopefully we can gain more insight into the functioning of [river basins’] response to climate change.”

    Indeed, the finding that rivers have “finite resilience” to drought is of particular concern as the planet warms and lengthier droughts become more likely, writes hydrologist Flavia Tauro in a commentary in the same issue of Science. More

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    New evidence for electron's dual nature found in a quantum spin liquid

    A new discovery led by Princeton University could upend our understanding of how electrons behave under extreme conditions in quantum materials. The finding provides experimental evidence that this familiar building block of matter behaves as if it is made of two particles: one particle that gives the electron its negative charge and another that supplies its magnet-like property, known as spin.
    “We think this is the first hard evidence of spin-charge separation,” said Nai Phuan Ong, Princeton’s Eugene Higgins Professor of Physics and senior author on the paper published this week in the journal Nature Physics.
    The experimental results fulfill a prediction made decades ago to explain one of the most mind-bending states of matter, the quantum spin liquid. In all materials, the spin of an electron can point either up or down. In the familiar magnet, all of the spins uniformly point in one direction throughout the sample when the temperature drops below a critical temperature.
    However, in spin liquid materials, the spins are unable to establish a uniform pattern even when cooled very close to absolute zero. Instead, the spins are constantly changing in a tightly coordinated, entangled choreography. The result is one of the most entangled quantum states ever conceived, a state of great interest to researchers in the growing field of quantum computing.
    To describe this behavior mathematically, Nobel prize-winning Princeton physicist Philip Anderson (1923-2020), who first predicted the existence of spin liquids in 1973, proposed an explanation: in the quantum regime an electron may be regarded as composed of two particles, one bearing the electron’s negative charge and the other containing its spin. Anderson called the spin-containing particle a spinon.
    In this new study, the team searched for signs of the spinon in a spin liquid composed of ruthenium and chlorine atoms. At temperatures a fraction of a Kelvin above absolute zero (or roughly -452 degrees Fahrenheit) and in the presence of a high magnetic field, ruthenium chloride crystals enter the spin liquid state. More

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    Quantum machine learning hits a limit

    A new theorem from the field of quantum machine learning has poked a major hole in the accepted understanding about information scrambling.
    “Our theorem implies that we are not going to be able to use quantum machine learning to learn typical random or chaotic processes, such as black holes. In this sense, it places a fundamental limit on the learnability of unknown processes,” said Zoe Holmes, a post-doc at Los Alamos National Laboratory and coauthor of the paper describing the work published today in Physical Review Letters.
    “Thankfully, because most physically interesting processes are sufficiently simple or structured so that they do not resemble a random process, the results don’t condemn quantum machine learning, but rather highlight the importance of understanding its limits,” Holmes said.
    In the classic Hayden-Preskill thought experiment, a fictitious Alice tosses information such as a book into a black hole that scrambles the text. Her companion, Bob, can still retrieve it using entanglement, a unique feature of quantum physics. However, the new work proves that fundamental constraints on Bob’s ability to learn the particulars of a given black hole’s physics means that reconstructing the information in the book is going to be very difficult or even impossible.
    “Any information run through an information scrambler such as a black hole will reach a point where the machine learning algorithm stalls out on a barren plateau and thus becomes untrainable. That means the algorithm can’t learn scrambling processes,” said Andrew Sornborger a computer scientist at Los Alamos and coauthor of the paper. Sornborger is Director of Quantum Science Center at Los Alamos and leader of the Center’s algorithms and simulation thrust. The Center is a multi-institutional collaboration led by Oak Ridge National Laboratory.
    Barren plateaus are regions in the mathematical space of optimization algorithms where the ability to solve the problem becomes exponentially harder as the size of the system being studied increases. This phenomenon, which severely limits the trainability of large scale quantum neural networks, was described in a recent paper by a related Los Alamos team.
    “Recent work has identified the potential for quantum machine learning to be a formidable tool in our attempts to understand complex systems,” said Andreas Albrecht, a co-author of the research. Albrecht is Director of the Center for Quantum Mathematics and Physics (QMAP) and Distinguished Professor, Department of Physics and Astronomy, at UC Davis. “Our work points out fundamental considerations that limit the capabilities of this tool.”
    In the Hayden-Preskill thought experiment, Alice attempts to destroy a secret, encoded in a quantum state, by throwing it into nature’s fastest scrambler, a black hole. Bob and Alice are the fictitious quantum dynamic duo typically used by physicists to represent agents in a thought experiment.
    “You might think that this would make Alice’s secret pretty safe,” Holmes said, “but Hayden and Preskill argued that if Bob knows the unitary dynamics implemented by the black hole, and share a maximally entangled state with the black hole, it is possible to decode Alice’s secret by collecting a few additional photons emitted from the black hole. But this prompts the question, how could Bob learn the dynamics implemented by the black hole? Well, not by using quantum machine learning, according to our findings.”
    A key piece of the new theorem developed by Holmes and her coauthors assumes no prior knowledge of the quantum scrambler, a situation unlikely to occur in real-world science.
    “Our work draws attention to the tremendous leverage even small amounts of prior information may play in our ability to extract information from complex systems and potentially reduce the power of our theorem,” Albrecht said. “Our ability to do this can vary greatly among different situations (as we scan from theoretical consideration of black holes to concrete situations controlled by humans here on earth). Future research is likely to turn up interesting examples, both of situations where our theorem remains fully in force, and others where it can be evaded. More

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    How AIs ask for personal information is important for gaining user trust

    People may be reluctant to give their personal information to artificial intelligence (AI) systems even though it is needed by the systems for providing more accurate and personalized services, but a new study reveals that the manner in which the systems ask for information from users can make a difference.
    In a study, Penn State researchers report that users responded differently when AIs either offered to help the user, or asked for help from the user. This response influenced whether the user trusted the AI with their personal information. They added that these introductions from the AI could be designed in a way to both increase users’ trust, as well as raise their awareness about the importance of personal information.
    The researchers, who presented their findings today at the virtual 2021 ACM CHI Conference on Human Factors in Computing Systems, the premier international conference of human-computer interaction research, found that people who are familiar with technology — power users — preferred AIs that are in need of help, or help-seeking, while non-expert users were more likely to prefer AIs that introduce themselves as simultaneously help-seekers and help-providers.
    As AIs become increasingly ubiquitous, developers need to create systems that can better relate to humans, said S. Shyam Sundar, James P. Jimirro Professor of Media Effects in the Donald P. Bellisario College of Communications and co-director of the Media Effects Research Laboratory.
    “There’s a need for us to re-think how AI systems talk to human users,” said Sundar. “This has come to the surface because there are rising concerns about how AI systems are starting to take over our lives and know more about us than we realize. So, given these concerns, it may be better if we start to switch from the traditional dialogue scripts into a more collaborative, cooperative communication that acknowledges the agency of the user.”
    Here to help?
    The researchers said that traditional AI dialogues usually offer introductions that frame their role as a helper. More