Aurelia Butler

Lithium metal batteries are among the most promising candidates of the next generation of high-energy batteries. They can store at least twice as much energy per unit of volume as the lithium-ion batteries that are in widespread use today. This will mean, for example, that an electric car can travel twice as far on a single charge, or that a smartphone will not have to be recharged so often.
At present, there is still one crucial drawback with lithium metal batteries: the liquid electrolyte requires the addition of significant amounts of fluorinated solvents and fluorinated salts, which increases its environmental footprint. Without the addition of fluorine, however, lithium metal batteries would be unstable, they would stop working after very few charging cycles and be prone to short circuits as well as overheating and igniting. A research group led by Maria Lukatskaya, Professor of Electrochemical Energy Systems at ETH Zurich, has now developed a new method that dramatically reduces the amount of fluorine required in lithium metal batteries, thereby rendering them more environmentally friendly and more stable as well as cost-effective.
A stable protective layer increases battery safety and efficiency
The fluorinated compounds from electrolyte help the formation of a protective layer around the metallic lithium at the negative electrode of the battery. “This protective layer can be compared to the enamel of a tooth,” Lukatskaya explains. “It protects the metallic lithium from continuous reaction with electrolyte components.” Without it, the electrolyte would quickly get depleted during cycling, the cell would fail, and the lack of a stable layer would result in the formation of lithium metal whiskers — ‘dendrites’ — during the recharging process instead of a conformal flat layer.
Should these dendrites touch the positive electrode, this would cause a short circuit with the risk that the battery heats up so much that it ignites. The ability to control the properties of this protective layer is therefore crucial for battery performance. A stable protective layer increases battery efficiency, safety and service life.
Minimising fluorine content
“The question was how to reduce the amount of added fluorine without compromising the protective layer’s stability,” says doctoral student Nathan Hong. The group’s new method uses electrostatic attraction to achieve the desired reaction. Here, electrically charged fluorinated molecules serve as a vehicle to transport the fluorine to the protective layer. This means that only 0.1 percent by weight of fluorine is required in the liquid electrolyte, which is at least 20 times lower than in prior studies.
Optimised method makes batteries greener
The ETH Zurich research group describes the new method and its underlying principles in a paper recently published in the journal Energy & Environmental Science. An application for a patent has been made.
One of the biggest challenges was to find the right molecule to which fluorine could be attached and that would also decompose again under the right conditions once it had reached the lithium metal. As the group explains, a key advantage of this method is that it can be seamlessly integrated into the existing battery production process without generating additional costs to change the production setup. The batteries used in the lab were the size of a coin. In a next step, the researchers plan to test the method’s scalability and apply it to pouch cells as used in smartphones. More

To perform quantum computations, quantum bits (qubits) must be cooled down to temperatures in the millikelvin range (close to -273 Celsius), to slow down atomic motion and minimize noise. However, the electronics used to manage these quantum circuits generate heat, which is difficult to remove at such low temperatures. Most current technologies must therefore separate quantum circuits from their electronic components, causing noise and inefficiencies that hinder the realization of larger quantum systems beyond the lab.
Researchers in EPFL’s Laboratory of Nanoscale Electronics and Structures (LANES), led by Andras Kis, in the School of Engineering have now fabricated a device that not only operates at extremely low temperatures, but does so with efficiency comparable to current technologies at room temperature.
“We are the first to create a device that matches the conversion efficiency of current technologies, but that operates at the low magnetic fields and ultra-low temperatures required for quantum systems. This work is truly a step ahead,” says LANES PhD student Gabriele Pasquale.
The innovative device combines the excellent electrical conductivity of graphene with the semiconductor properties of indium selenide. Only a few atoms thick, it behaves as a two-dimensional object, and this novel combination of materials and structure yields its unprecedented performance. The achievement has been published in Nature Nanotechnology.
Harnessing the Nernst effect
The device exploits the Nernst effect: a complex thermoelectric phenomenon that generates an electrical voltage when a magnetic field is applied perpendicular to an object with a varying temperature. The two-dimensional nature of the lab’s device allows the efficiency of this mechanism to be controlled electrically.
The 2D structure was fabricated at the EPFL Center for MicroNanoTechnology and the LANES lab. Experiments involved using a laser as a heat source, and a specialized dilution refrigerator to reach 100 millikelvin — a temperature even colder than outer space. Converting heat to voltage at such low temperatures is usually extremely challenging, but the novel device and its harnessing of the Nernst effect make this possible, filling a critical gap in quantum technology.
“If you think of a laptop in a cold office, the laptop will still heat up as it operates, causing the temperature of the room to increase as well. In quantum computing systems, there is currently no mechanism to prevent this heat from disturbing the qubits. Our device could provide this necessary cooling,” Pasquale says.
A physicist by training, Pasquale emphasizes that this research is significant because it sheds light on thermopower conversion at low temperatures — an underexplored phenomenon until now. Given the high conversion efficiency and the use of potentially manufacturable electronic components, the LANES team also believes their device could already be integrated into existing low-temperature quantum circuits.
“These findings represent a major advancement in nanotechnology and hold promise for developing advanced cooling technologies essential for quantum computing at millikelvin temperatures,” Pasquale says. “We believe this achievement could revolutionize cooling systems for future technologies.” More

Drosophila — commonly known as fruit flies — are a valuable model for human heart pathophysiology, including cardiac aging and cardiomyopathy. However, a choke point in evaluating fruit fly hearts is the need for human intervention to measure the heart at moments of its largest expansion or its greatest contraction, measurements that allow calculations of cardiac dynamics.
Researchers at the University of Alabama at Birmingham now show a way to significantly cut the time needed for that analysis while utilizing more of the heart region, using deep learning and high-speed video microscopy for each heartbeat in the fly.
“Our machine learning method is not just fast; it minimizes human error because you don’t have to manually mark each heart wall under systolic and diastolic conditions,” said Girish Melkani, Ph.D., associate professor in the UAB Department of Pathology, Division of Molecular and Cellular Pathology. “Furthermore, you can run the analyses of several hundred hearts and look at the analyses when done for all the hearts.”
This can expand the ability to test how different environmental or genetic factors affect heart aging or pathology. Melkani envisions using deep learning-assisted studies to explore cardiac mutation models and other small animal models, such as zebrafish and mice. “Additionally, our techniques could be adapted for human heart models, providing valuable insights into cardiac health and disease. Incorporating uncertainty quantification methods could further enhance the reliability of our analyses. Moreover, the machine learning approach can predict cardiac aging with high accuracy.”
The fruit fly model has already been tremendously powerful for understanding the pathophysiological bases for several human cardiovascular diseases, Melkani says. Cardiovascular disease continues to be one of the leading causes of death and disability in the United States.
Melkani and UAB colleagues assessed their trained model on heart performance both in fruit fly cardiac aging and in a fruit fly model of dilated cardiomyopathy caused by the knockdown of a pivotal TCA cycle enzyme, oxoglutarate dehydrogenase. These automated assessments were then validated against existing experimental datasets. For example, for aging of fruit flies at one week versus five weeks of age, which is about halfway through a fruit fly’s life span, the UAB team used 54 hearts for model training and then validated their measurements against an experimental aging model with 177 hearts. Their trained model was able to reconstruct expected trends in cardiac parameters with aging.
Melkani says his team’s model can be applied to readily available consumer hardware, and his team’s code can provide calculated statistics including diastolic and systolic diameters/intervals, fractional shortening, ejection fraction, heart period/rate, and quantified heartbeat arrhythmicity.
“To our knowledge, this innovative platform for deep learning-assisted segmentation is the first of its kind to be applied to standard high-resolution high-speed optical microscopy of Drosophila hearts while also quantifying all relevant parameters,” Melkani said.
“By automating the process and providing detailed cardiac statistics, we pave the way for more accurate, efficient and comprehensive studies of heart function in Drosophila. This method holds tremendous potential — not only for understanding aging and disease in fruit flies — but also for translating these insights into human cardiovascular research.” More