Computers Math

An online course designed to curb negative thinking has had strong results in helping people reduce the time they spend ruminating and worrying, a new study from UNSW Sydney has shown.
And researchers say the online course, which will soon be hosted on the Australian Government funded online clinic This Way Up and is free with a prescription from a clinician, was found to significantly improve the mental health of the people who participated in the study. The trial was part of a collaboration between UNSW, the Black Dog Institute and The Clinical Research Unit for Anxiety and Depression at St Vincent’s Health Network.
The Managing Rumination and Worry Program features three lessons to be completed over a six-week period. It aims to help participants reduce their levels of rumination, which is dwelling on past negative experiences, and worry, which is thinking over and over about bad things happening in future.
Professor Jill Newby, who is a clinical psychologist with UNSW’s School of Psychology and the affiliated Black Dog Institute, says when the call went out to recruit people for the randomised controlled trial, the team was inundated with applications.
“Out of all the research we’ve done on online therapies, this is by far the most popular program we’ve done,” Prof. Newby says.
“We got way more applicants for what we could manage in a very quick timeframe. So it’s clear there is a community need for help with rumination and worry.”
The researchers recruited 137 adults who were experiencing elevated levels of repetitive negative thinking. They were randomly allocated to one of three groups: a clinician-guided, three-lesson online course delivered over six weeks; the same course but without the assistance of a clinician; or a control group who received the online course after an 18-week waiting period. More

Even when humans see AI-based assistants purely as tools, they ascribe partial responsibility for decisions to them, as a new study shows.
Future AI-based systems may navigate autonomous vehicles through traffic with no human input. Research has shown that people judge such futuristic AI systems to be just as responsible as humans when they make autonomous traffic decisions. However, real-life AI assistants are far removed from this kind of autonomy. They provide human users with supportive information such as navigation and driving aids. So, who is responsible in these real-life cases when something goes right or wrong? The human user? Or the AI assistant? A team led by Louis Longin from the Chair of Philosophy of Mind has now investigated how people assess responsibility in these cases.
“We all have smart assistants in our pockets,” says Longin. “Yet a lot of the experimental evidence we have on responsibility gaps focuses on robots or autonomous vehicles where AI is literally in the driver’s seat, deciding for us. Investigating cases where we are still the ones making the final decision, but use AI more like a sophisticated instrument, is essential.”
A philosopher specialized in the interaction between humans and AI, Longin, working in collaboration with his colleague Dr. Bahador Bahrami and Prof. Ophelia Deroy, Chair of Philosophy of Mind, investigated how 940 participants judged a human driver using either a smart AI-powered verbal assistant, a smart AI-powered tactile assistant, or a non-AI navigation instrument. Participants also indicated whether they saw the navigation aid as responsible, and to which degree it was a tool.
Ambivalent status of smart assistants
The results reveal an ambivalence: Participants strongly asserted that smart assistants were just tools, yet they saw them as partly responsible for the success or failures of the human drivers who consulted them. No such division of responsibility occurred for the non-AI powered instrument.
No less surprising for the authors was that the smart assistants were also considered more responsible for positive rather than negative outcomes. “People might apply different moral standards for praise and blame. When a crash is averted and no harm ensues, standards are relaxed, making it easier for people to assign credit than blame to non-human systems” suggests Dr. Bahrami, who is an expert on collective responsibility. More

Coming to a tight spot near you: CLARI, the little, squishable robot that can passively change its shape to squeeze through narrow gaps — with a bit of inspiration from the world of bugs.
CLARI, which stands for Compliant Legged Articulated Robotic Insect, comes from a team of engineers at the University of Colorado Boulder. It also has the potential to aid first responders after major disasters in an entirely new way.
Several of these robots can easily fit in the palm of your hand, and each weighs less than a Ping Pong ball. CLARI can transform its shape from square to long and slender when its surroundings become cramped, said Heiko Kabutz, a doctoral student in the Paul M. Rady Department of Mechanical Engineering.
Kabutz and his colleagues introduced the miniature robot in a study published Aug. 30 in the journal “Advanced Intelligent Systems.”
Right now, CLARI has four legs. But the machine’s design allows engineers to mix and match its appendages, potentially giving rise to some wild and wriggly robots.
“It has a modular design, which means it’s very easy to customize and add more legs,” Kabutz said. “Eventually, we’d like to build an eight-legged, spider-style robot that could walk over a web.”
CLARI is still in its infancy, added Kaushik Jayaram, co-author of the study and an assistant professor of mechanical engineering at CU Boulder. The robot, for example, is tethered to wires, which supply it with power and send it basic commands. But he hopes that, one day, these petite machines could crawl independently into spaces where no robot has crawled before — like the insides of jet engines or the rubble of collapsed buildings. More

Nearly half of all patients with brain metastasis experience cognitive impairment. Until now, it was thought that this was due to the physical presence of the tumour pressing on neural tissue. But this ‘mass effect’ hypothesis is flawed because there is often no relationship between the size of the tumour and its cognitive impact. Small tumours can cause significant changes, and large tumours can produce mild effects. Why is this?
The explanation may lie in the fact that brain metastasis hacks the brain’s activity, a study featured on Cancer Cell’s cover shows for the first time.
The authors, from the Spanish National Research Council (CSIC) and the Spanish National Cancer Research Centre (CNIO), have discovered that when cancer spreads (metastasises) in the brain, it changes the brain’s chemistry and disrupts neuronal communication — neurons communicate through electrical impulses generated and transmitted by biochemical changes in the cells and their surroundings.
In this study, the laboratories of Manuel Valiente (CNIO) and Liset Menéndez de La Prida (Cajal Institute CSIC) have collaborated within the EU-funded NanoBRIGHT project, aimed at developing new technologies for the study of the brain, and with the participation of other funding agencies such as MICINN, AECC, ERC, NIH and EMBO.
Demonstration with artificial intelligence
The researchers measured the electrical activity of the brains of mice with and without metastases and observed that the electrophysiological recordings of the two groups of animals with cancer were different from each other. To be sure that this difference was attributable to metastases, they turned to artificial intelligence. They trained an automatic algorithm with numerous electrophysiological recordings, and the model was indeed able to identify the presence of metastases. The system was even able to distinguish metastases from different primary tumours — skin, lung and breast cancer.
These results show that metastasis does indeed affect the brain’s electrical activity in a specific way, leaving clear and recognizable signatures. More

University of Oxford researchers have made a significant step towards realising miniature bio-integrated devices, capable of directly stimulating cells. The work has been published today in the journal Nature.
Small bio-integrated devices that can interact with and stimulate cells could have important therapeutic applications, including the delivery of targeted drug therapies and the acceleration of wound healing. However, such devices all need a power source to operate. To date, there has been no efficient means to provide power at the microscale level.
To address this, researchers fromthe University of Oxford’s Department of Chemistry have developed a miniature power source capable of altering the activity of cultured human nerve cells. Inspired by how electric eels generate electricity, the device uses internal ion gradients to generate energy.
The miniaturized soft power source is produced by depositing a chain of five nanolitre-sized droplets of a conductive hydrogel (a 3D network of polymer chains containing a large quantity of absorbed water). Each droplet has a different composition so that a salt concentration gradient is created across the chain. The droplets are separated from their neighbours by lipid bilayers, which provide mechanical support while preventing ions from flowing between the droplets.
The power source is turned on by cooling the structure to 4°C and changing the surrounding medium: this disrupts the lipid bilayers and causes the droplets to form a continuous hydrogel. This allows the ions to move through the conductive hydrogel, from the high-salt droplets at the two ends to the low-salt droplet in the middle. By connecting the end droplets to electrodes, the energy released from the ion gradients is transformed into electricity, enabling the hydrogel structure to act as a power source for external components.
In the study, the activated droplet power source produced a current which persisted for over 30 minutes. The maximum output power of a unit made of 50 nanolitre droplets was around 65 nanowatts (nW). The devices produced a similar amount of current after being stored for 36 hours.
The research team then demonstrated how living cells could be attached to one end of the device so that their activity could be directly regulated by the ionic current. The team attached the device to droplets containing human neural progenitor cells, which had been stained with a fluorescent dye to indicate their activity. When the power source was turned on, time-lapse recording demonstrated waves of intercellular calcium signalling* in the neurons, induced by the local ionic current. More

Quantum physics has allowed for the creation of sensors far surpassing the precision of classical devices. Now, several studies in Nature show that the precision of these quantum sensors can be significantly improved using entanglement produced by finite-range interactions. Innsbruck researchers led by Christian Roos were able to demonstrate this enhancement using entangled ion-chains with up to 51 particles.
Metrological institutions around the world administer our time, using atomic clocks based on the natural oscillations of atoms. These clocks, pivotal for applications like satellite navigation or data transfer, have recently been improved by using ever higher oscillation frequencies in optical atomic clocks. Now, scientists at the University of Innsbruck and the Institute of Quantum Optics and Quantum Information (IQOQI) of the Austrian Academy of Sciences led by Christian Roos show how a particular way of creating entanglement can be used to further improve the accuracy of measurements integral to an optical atomic clock’s function.
Measurement error halved in experiment
Observations of quantum systems are always subject to a certain statistical uncertainty. “This is due to the nature of the quantum world,” explains Johannes Franke from Christian Roos’ team. “Entanglement can help us reduce these errors.” With the support of theorist Ana Maria Rey from JILA in Boulder, USA, the Innsbruck physicists tested the measurement accuracy on an entangled ensemble of particles in the laboratory. The researchers used lasers to tune the interaction of ions lined up in a vacuum chamber and entangled them. “The interaction between neighboring particles decreases with the distance between the particles. Therefore, we used spin-exchange interactions to allow the system to behave more collectively,” explains Raphael Kaubrügger from the Department of Theoretical Physics at the University of Innsbruck. Thus, all particles in the chain were entangled with each other and produced a so-called squeezed quantum state. Using this, the physicists were able to show that measurement errors can be roughly halved by entangling 51 ions in relation to individual particles. Previously, entanglement-enhanced sensing mainly relied on infinite interactions, limiting its applicability to only certain quantum platforms.
Even more accurate clocks
With their experiments, the Innsbruck quantum physicists were able to show that quantum entanglement makes sensors even more sensitive. “We used an optical transition in our experiments that is also employed in atomic clocks,” says Christian Roos. This technology could improve areas where atomic clocks are currently used, such as satellite-based navigation or data transfer. Moreover, these advanced clocks could open new possibilities in pursuits like the search for dark matter or the determination of time-variations of fundamental constants.
Christian Roos and his team now want to test the new method in two-dimensional ion ensembles. The current results were published in the journal Nature. In the same issue, researchers published very similar results using neutral atoms. The research in Innsbruck was financially supported by the Austrian Science Fund FWF and the Federation of Austrian Industries Tyrol, among others. More

A team of researchers from Yale University and other institutions globally has developed an innovative patient triage platform powered by artificial intelligence (AI) that the researchers say is capable of predicting patient disease severity and length of hospitalization during a viral outbreak.
The platform, which leverages machine learning and metabolomics data, is intended to improve patient management and help health care providers allocate resources more efficiently during severe viral outbreaks that can quickly overwhelm local health care systems. Metabolomics is the study of small molecules related to cell metabolism.
“Being able to predict which patients can be sent home and those possibly needing intensive care unit admission is critical for health officials seeking to optimize patient health outcomes and use hospital resources most efficiently during an outbreak,” said senior author Vasilis Vasiliou, a professor of epidemiology at Yale School of Public Health (YSPH).The researchers developed the platform using COVID-19 as a disease model. The findings were published online in the journal Human Genomics.
The platform integrates routine clinical data, patient comorbidity information, and untargeted plasma metabolomics data to drive its predictions.
“Our AI-powered patient triage platform is distinct from typical COVID-19 AI prediction models,” said Georgia Charkoftaki, a lead author of the study and an associate research scientist in the Department of Environmental Health Sciences at YSPH. “It serves as the cornerstone for a proactive and methodical approach to addressing upcoming viral outbreaks.”
Using machine learning, the researchers built a model of COVID-19 severity and prediction of hospitalization based on clinical data and metabolic profiles collected from patients hospitalized with the disease. “The model led us to identify a panel of unique clinical and metabolic biomarkers that were highly indicative of disease progression and allows the prediction of patient management needs very soon after hospitalization,” the researchers wrote in the study.
For the study, the research team collected comprehensive data from 111 COVID-19 patients admitted to Yale New Haven Hospital during a two-month period in 2020 and 342 healthy individuals (health care workers) who served as controls. The patients were categorized into different classes based on their treatment needs, ranging from not requiring external oxygen to requiring positive airway pressure or intubation. More

Recently, a Korean company donated a wearable robot, designed to aid patients with limited mobility during their rehabilitation, to a hospital. These patients wear this robot to receive assistance for muscle and joint exercises while performing actions such as walking or sitting. Wearable devices including smartwatches or eyewear that people wear and attached to their skin have the potential to enhance our quality of life, offering a glimmer of hope to some people much like this robotic innovation.
The strain sensors used in these rehabilitative robots analyze data by translating specific physical changes in specific regions into electric signals. Notably flexible, these sensors are pliable and adept at gauging even the most subtle bodily changes as they are made from lightweight materials for ease of attachment to the skin. However, conventional soft strain sensors often exhibit inadequate durability due to susceptibility to external factors such as temperature and humidity. Furthermore, their complicated fabrication process poses challenges for widespread commercialization.
A research team led by Professor Sung-Min Park from the Department of Convergence IT Engineering and the Department of Mechanical Engineering and PhD candidate Sunguk Hong from the Department of Mechanical Engineering at Pohang University of Science and Technology (POSTECH) has successfully overcome the limitations of these soft strain sensors by integrating computer vision technology into optical sensors. Their research findings were featured in npj Flexible Electronics.
The research team developed a sensor technology known as computer vision-based optical strain (CVOS) during their study. Unlike conventional sensors reliant on electrical signals, CVOS sensors employ computer vision and optical sensors to analyze microscale optical patterns, extracting data regarding changes. This approach inherently enhances durability by eliminating elements that compromise sensor functionalities and streamlining fabrication processes, thereby facilitating sensor commercialization.
In contrast to conventional sensors that solely detect biaxial strain, CVOS sensors exhibit the exceptional ability to detect three-axial rotational movements through real-time multiaxial strain mapping. In essence, these sensors enable the precise recognition of intricate and various bodily motions through a single sensor. The research team substantiated this claim through experiments applying CVOS sensors to assistive devices in rehabilitative treatments.
Through integration of an AI-based response correction algorithm that corrects diverse error factors arising during signal detection, the experiment results showed a high level of confidence. Even after undergoing more than 10,000 iterations, these sensors consistently maintained their exceptional performance.
Professor Sung-Min Park who led the research explained, “The CVOS sensors excel in distinguishing body movements across diverse direction and angles, thereby optimizing effective rehabilitative interventions.” He further added, “By tailoring design indicators and algorithms to align with specific objectives, CVOS sensors have boundless potential for applications spanning industries.” More