Computers Math

Researchers from the Department of Mechanical Science and Bioengineering at Osaka University have invented a new kind of walking robot that takes advantage of dynamic instability to navigate. By changing the flexibility of the couplings, the robot can be made to turn without the need for complex computational control systems. This work may assist the creation of rescue robots that are able to traverse uneven terrain.
Most animals on Earth have evolved a robust locomotion system using legs that provides them with a high degree of mobility over a wide range of environments. Somewhat disappointingly, engineers who have attempted to replicate this approach have often found that legged robots are surprisingly fragile. The breakdown of even one leg due to the repeated stress can severely limit the ability of these robots to function. In addition, controlling a large number of joints so the robot can transverse complex environments requires a lot of computer power. Improvements in this design would be extremely useful for building autonomous or semi-autonomous robots that could act as exploration or rescue vehicles and enter dangerous areas.
Now, investigators from Osaka University have developed a biomimetic “myriapod” robot that takes advantage of a natural instability that can convert straight walking into curved motion. In a study published recently in Soft Robotics, researchers from Osaka University describe their robot, which consists of six segments (with two legs connected to each segment) and flexible joints. Using an adjustable screw, the flexibility of the couplings can be modified with motors during the walking motion. The researchers showed that increasing the flexibility of the joints led to a situation called a “pitchfork bifurcation,” in which straight walking becomes unstable. Instead, the robot transitions to walking in a curved pattern, either to the right or to the left. Normally, engineers would try to avoid creating instabilities. However, making controlled use of them can enable efficient maneuverability. “We were inspired by the ability of certain extremely agile insects that allows them to control the dynamic instability in their own motion to induce quick movement changes,” says Shinya Aoi, an author of the study. Because this approach does not directly steer the movement of the body axis, but rather controls the flexibility, it can greatly reduce both the computational complexity as well as the energy requirements.
The team tested the robot’s ability to reach specific locations and found that it could navigate by taking curved paths toward targets. “We can foresee applications in a wide variety of scenarios, such as search and rescue, working in hazardous environments or exploration on other planets,” says Mau Adachi, another study author. Future versions may include additional segments and control mechanisms. More

Engineers at the University of California San Diego have developed a simple, low-cost clip that uses a smartphone’s camera and flash to monitor blood pressure at the user’s fingertip. The clip works with a custom smartphone app and currently costs about 80 cents to make. The researchers estimate that the cost could be as low as 10 cents apiece when manufactured at scale.
The technology was published May 29 in Scientific Reports.
Researchers say it could help make regular blood pressure monitoring easy, affordable and accessible to people in resource-poor communities. It could benefit older adults and pregnant women, for example, in managing conditions such as hypertension.
“We’ve created an inexpensive solution to lower the barrier to blood pressure monitoring,” said study first author Yinan (Tom) Xuan, an electrical and computer engineering Ph.D. student at UC San Diego.
“Because of their low cost, these clips could be handed out to anyone who needs them but cannot go to a clinic regularly,” said study senior author Edward Wang, a professor of electrical and computer engineering at UC San Diego and director of the Digital Health Lab. “A blood pressure monitoring clip could be given to you at your checkup, much like how you get a pack of floss and toothbrush at your dental visit.”
Another key advantage of the clip is that it does not need to be calibrated to a cuff.

“This is what distinguishes our device from other blood pressure monitors,” said Wang. Other cuffless systems being developed for smartwatches and smartphones, he explained, require obtaining a separate set of measurements with a cuff so that their models can be tuned to fit these measurements.
“Our is a calibration-free system, meaning you can just use our device without touching another blood pressure monitor to get a trustworthy blood pressure reading.”
To measure blood pressure, the user simply presses on the clip with a fingertip. A custom smartphone app guides the user on how hard and long to press during the measurement.
The clip is a 3D-printed plastic attachment that fits over a smartphone’s camera and flash. It features an optical design similar to that of a pinhole camera. When the user presses on the clip, the smartphone’s flash lights up the fingertip. That light is then projected through a pinhole-sized channel to the camera as an image of a red circle. A spring inside the clip allows the user to press with different levels of force. The harder the user presses, the bigger the red circle appears on the camera.
The smartphone app extracts two main pieces of information from the red circle. By looking at the size of the circle, the app can measure the amount of pressure that the user’s fingertip applies. And by looking at the brightness of the circle, the app can measure the volume of blood going in and out of the fingertip. An algorithm converts this information into systolic and diastolic blood pressure readings.

The researchers tested the clip on 24 volunteers from the UC San Diego Medical Center. Results were comparable to those taken by a blood pressure cuff.
“Using a standard blood pressure cuff can be awkward to put on correctly, and this solution has the potential to make it easier for older adults to self-monitor blood pressure,” said study co-author and medical collaborator Alison Moore, chief of the Division of Geriatrics in the Department of Medicine at UC San Diego School of Medicine.
While the team has only proven the solution on a single smartphone model, the clip’s current design theoretically should work on other phone models, said Xuan.
Wang and one of his lab members, Colin Barry, a co-author on the paper who is an electrical and computer engineering student at UC San Diego, co-founded a company, Billion Labs Inc., to refine and commercialize the technology.
Next steps include making the technology more user friendly, especially for older adults; testing its accuracy across different skin tones; and creating a more universal design.
Paper: “Ultra-low-cost Mechanical Smartphone Attachment for No-Calibration Blood Pressure Measurement.” Co-authors include Jessica De Souza, Jessica Wen and Nick Antipa, all at UC San Diego.
This work is supported by the National Institute of Aging Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer’s Disease (MassAITC P30AG073107 Subaward 23-016677 N 00), the Altman Clinical and Translational Research Institute Galvanizing Engineering in Medicine (GEM) Awards, and a Google Research Scholar Award.
Disclosures: Edward Wang and Colin Barry are co-founders of and have a financial interest in Billion Labs Inc. Wang is also the CEO of Billion Labs Inc. The other authors declare that they have no competing interests. The terms of this arrangement have been reviewed and approved by the University of California San Diego in accordance with its conflict-of-interest policies. More

Solvated dielectrons are the subject of many hypotheses among scientists, but have never been directly observed. They are described as a pair of electrons that is dissolved in liquids such as water or liquid ammonia. To make space for the electrons a cavity forms in the liquid, which the two electrons occupy. An international research team around Dr. Sebastian Hartweg, initially at Synchrotron SOLEIL (France), now at the Institute of Physics at the University of Freiburg and Prof. Dr. Ruth Signorell from ETH Zurich, including scientists from the synchrotron SOLEIL and Auburn University (US) has now succeeded in discovering a formation and decay process of the solvated dielectron. In experiments at the synchrotron SOLEIL (DESIRS beamline), the consortium found direct evidence supported by quantum chemical calculations for the formation of these electron pairs by excitation with ultraviolet light in tiny ammonia droplets containing a single sodium atom. The results were recently published in the scientific journal Science.
Traces of an unusual process
When dielectrons are formed by excitation with ultraviolet light in tiny ammonia droplets containing a sodium atom, they leave traces in an unusual process that scientists have now been able to observe for the first time. In this process, one of the two electrons migrates to the neighbouring solvent molecules, while at the same time the other electron is ejected. “The surprising thing about this is that similar processes have previously been observed mainly at much higher excitation energies,” says Hartweg. The team focused on this second electron because there could be interesting applications for it. On the one hand, the ejected electron is produced with very low kinetic energy, so it moves very slowly. On the other hand, this energy can be controlled by the irradiated UV light, which starts the whole process. Solvated dielectrons could thus serve as a good source of low-energy electrons.
Generated specifically with variable energy
Such slow electrons can set a wide variety of chemical processes in motion. For example, they play a role in the cascade of processes that lead to radiation damage in biological tissue. They are also important in synthetic chemistry, where they serve as effective reducing agents. By being able to selectively generate slow electrons with variable energy, the mechanisms of such chemical processes can be studied in more detail in the future. In addition, the energy made available to the electrons in a controlled manner might also be used to increase the effectiveness of reduction reactions. “These are interesting prospects for possible applications in the future,” says Hartweg. “Our work provides the basis for this and helps to understand these exotic and still enigmatic solvated dielectrons a little better.” More

Infections caused by fungi, such as Candida albicans, pose a significant global health risk due to their resistance to existing treatments, so much so that the World Health Organization has highlighted this as a priority issue.
Although nanomaterials show promise as antifungal agents, current iterations lack the potency and specificity needed for quick and targeted treatment, leading to prolonged treatment times and potential off-target effects and drug resistance.
Now, in a groundbreaking development with far-reaching implications for global health, a team of researchers jointly led by Hyun (Michel) Koo of the University of Pennsylvania School of Dental Medicine and Edward Steager of Penn’s School of Engineering and Applied Science has created a microrobotic system capable of rapid, targeted elimination of fungal pathogens.
“Candidae forms tenacious biofilm infections that are particularly hard to treat,” Koo says. “Current antifungal therapies lack the potency and specificity required to quickly and effectively eliminate these pathogens, so this collaboration draws from our clinical knowledge and combines Ed’s team and their robotic expertise to offer a new approach.”
The team of researchers is a part of Penn Dental’s Center for Innovation & Precision Dentistry, an initiative that leverages engineering and computational approaches to uncover new knowledge for disease mitigation and advance oral and craniofacial health care innovation.
For this paper, published in Advanced Materials, the researchers capitalized on recent advancements in catalytic nanoparticles, known as nanozymes, and they built miniature robotic systems that could accurately target and quickly destroy fungal cells. They achieved this by using electromagnetic fields to control the shape and movements of these nanozyme microrobots with great precision.

“The methods we use to control the nanoparticles in this study are magnetic, which allows us to direct them to the exact infection location,” Steager says. “We use iron oxide nanoparticles, which have another important property, namely that they’re catalytic.”
Steager’s team developed the motion, velocity, and formations of nanozymes, which resulted in enhanced catalytic activity, much like the enzyme peroxidase, which helps break down hydrogen peroxide into water and oxygen. This directly allows the generation of high amounts of reactive oxygen species (ROS), compounds that have proven biofilm-destroying properties, at the site of infection.
However, the truly pioneering element of these nanozyme assemblies was an unexpected discovery: their strong binding affinity to fungal cells. This feature enables a localized accumulation of nanozymes precisely where the fungi reside and, consequently, targeted ROS generation.
“Our nanozyme assemblies show an incredible attraction to fungal cells, particularly when compared to human cells,” Steager says. “This specific binding interaction paves the way for a potent and concentrated antifungal effect without affecting other uninfected areas.”
Coupled with the nanozyme’s inherent maneuverability, this results in a potent antifungal effect, demonstrating the rapid eradication of fungal cells within an unprecedented 10-minute window.
Looking forward, the team sees the potential of this unique nanozyme-based robotics approach, as they incorporate new methods to automate control and delivery of nanozymes. The promise it holds for antifungal therapy is just the beginning. Its precise targeting, rapid action suggest potential for treating other types of stubborn infections.
“We’ve uncovered a powerful tool in the fight against pathogenic fungal infections,” Koo says. “What we have achieved here is a significant leap forward, but it’s also just the first step. The magnetic and catalytic properties combined with unexpected binding specificity to fungi open exciting opportunities for an automated ‘target-bind-and-kill’ antifungal mechanism. We are eager to delve deeper and unlock its full potential.”
This robotics approach opens up a new frontier in the fight against fungal infections and marks a pivotal point in antifungal therapy. With a new tool in their arsenal, medical and dental professionals are closer than ever to effectively combating these difficult pathogens. More

The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases like diabetes and cancer.
Traditional synthetic biology approaches for cell-based therapies, such as ones that destroy cancer cells or encourage tissue regeneration after injury, rely on the expression or suppression of proteins that produce a desired action within a cell. This approach can take time (for proteins to be expressed and degrade) and cost cellular energy in the process. A team of Penn State College of Medicine and Huck Institutes of the Life Sciences researchers are taking a different approach.
“We’re engineering proteins that directly produce a desired action,” said Nikolay Dokholyan, G. Thomas Passananti Professor and vice chair for research in the Department of Pharmacology. “Our protein-based devices or nano-computing agents respond directly to stimuli (inputs) and then produce a desired action (outputs).”
In a study published in Science Advances today (May 26) Dokholyan and bioinformatics and genomics doctoral student Jiaxing Chen describe their approach to creating their nano-computing agent. They engineered a target protein by integrating two sensor domains, or areas that respond to stimuli. In this case, the target protein responds to light and a drug called rapamycin by adjusting its orientation, or position in space.
To test their design, the team introduced their engineered protein into live cells in culture. By exposing the cultured cells to the stimuli, they used equipment to measure changes in cellular orientation after cells were exposed to the sensor domains’ stimuli.
Previously, their nano-computing agent required two inputs to produce one output. Now, Chen says there are two possible outputs and the output depends on which order the inputs are received. If rapamycin is detected first, followed by light, the cell will adopt one angle of cell orientation, but if the stimuli are received in a reverse order, then the cell adopts a different orientation angle. Chen says this experimental proof-of-concept opens the door for the development of more complex nano-computing agents.
“Theoretically, the more inputs you embed into a nano-computing agent, the more potential outcomes that could result from different combinations,” Chen said. “Potential inputs could include physical or chemical stimuli and outputs could include changes in cellular behaviors, such as cell direction, migration, modifying gene expression and immune cell cytotoxicity against cancer cells.”
The team plans to further develop their nano-computing agents and experiment with different applications of the technology. Dokholyan, a researcher with Penn State Cancer Institute and Penn State Neuroscience Institute, said their concept could someday form the basis of the next-generation cell-based therapies for various diseases, such as autoimmune diseases, viral infections, diabetes, nerve injury and cancer.
Yashavantha Vishweshwaraiah, Richard Mailman and Erdem Tabdanov of Penn State College of Medicine also contributed to this research. The authors declare no conflicts of interest.
This work was funded by the National Institutes of Health (grant 1R35GM134864) and the Passan Foundation. More

Miniaturization is progressing rapidly in just any field and the trend towards the creation of ever smaller units is also prevalent in the world of robot technology. In the future, minuscule robots used in medical and pharmaceutical applications might be able to transport medication to targeted sites in the body. Statistical physics can contribute to the foundations for the development of such technologies. A team of researchers at Johannes Gutenberg University Mainz (JGU) has now taken a new approach to the issue by analyzing a group of robots and how they behave as collectives of motile units based on the model of active Brownian particles. The team’s findings demonstrating that there may be an alternative route to realize programmable active matter have been published in Science Advances.
Collectives of robotic units could solve tasks that a single machine can not solve on its own
Researchers are looking for new ways to perform tasks on the micro- and nanoscale that are otherwise difficult to realize, particularly as the miniaturization of devices and components is beginning to reach physical limits. One new option being considered is the use of collectives of robotic units in place of a single robot to complete a task. “The task-solving capabilities of one microrobot are limited due to its small size,” said Professor Thomas Speck, who headed the study at Mainz University. “But a collective of such robots working together may well be able to carry out complex assignments with considerable success.” Statistical physics becomes relevant here in that it analyzes models to describe how such collective behavior may emerge from interactions, comparable to bird behavior when they flock together.
The research team studied the collective behavior of a number of small, commercially available robots. These so-called walkers are propelled through internal vibrations transmitted to two rows of tiny legs. Because the length, shape, and stiffness of the legs differ slightly from robot to robot, they follow circular orbits with a radius that is specific to each individual walker. Looking and moving like little beetles, these robots have an elliptical form and are sent off in a new direction when they happen to collide with each other.
“Our aim was to examine and describe the collective behavior of these robots and determine whether it might be possible to derive potential uses from this,” added Frank Siebers, lead author of the paper. “At the same time, we as physicists were also interested in the phenomena per se.” The researchers were able to observe two effects when the collective of robots has variations in terms of their orbits, i.e., in a group showing greater diversity. Firstly, the walkers required less time to explore the space they were placed in. And secondly, when contained within an enclosed space, they began to undergo self-organized sorting. Depending on their orbital radius, the robots either accumulated at the confining wall or began to gather within the interior of the space.
Statistical physics provides insights into the behavior of collectives
“It would be possible to exploit this kind of activity to get robots to transport a load and to interact with that load, for example. The speed with which they would be able to traverse spaces would increase, meaning that the load would be delivered sooner,” said Professor Thomas Speck, outlining one potential application. “Statistical physics can help to uncover new strategies that may be utilized by collectives of robots.”
The field of active matter models and robotics covers many realms of the living and the nonliving world in which collective behavior or collective movement can be observed, one prominent example being the way that flocks of birds move in unison. “What we have done here is to apply the theory underlying our understanding of clustering and swarming to robotic systems,” said Frank Siebers of JGU.
The research was funded under the aegis of the Collaborative Research Center/TRR 146 on Multiscale Simulation Methods for Soft Matter Systems, a cooperative project involving Johannes Gutenberg University Mainz, TU Darmstadt, and the Max Planck Institute for Polymer Research. The researchers based their conclusions on the outcome of their experiments as well as on model computations performed on JGU’s supercomputer MOGON II. Principal investigator Professor Thomas Speck held a professorship at the JGU Institute of Physics from 2013 to 2022. He is now head of the Institute for Theoretical Physics IV of the University of Stuttgart. More

Philosophers and legal scholars have explored significant aspects of the moral and legal status of robots, with some advocating for giving robots rights. As robots assume more roles in the world, a new analysis reviewed research on robot rights, concluding that granting rights to robots is a bad idea. Instead, the article looks to Confucianism to offer an alternative.
The analysis, by a researcher at Carnegie Mellon University (CMU), appears in Communications of the ACM, published by the Association for Computing Machinery.
“People are worried about the risks of granting rights to robots,” notes Tae Wan Kim, Associate Professor of Business Ethics at CMU’s Tepper School of Business, who conducted the analysis. “Granting rights is not the only way to address the moral status of robots: Envisioning robots as rites bearers — not a rights bearers — could work better.”
Although many believe that respecting robots should lead to granting them rights, Kim argues for a different approach. Confucianism, an ancient Chinese belief system, focuses on the social value of achieving harmony; individuals are made distinctively human by their ability to conceive of interests not purely in terms of personal self-interest, but in terms that include a relational and a communal self. This, in turn, requires a unique perspective on rites, with people enhancing themselves morally by participating in proper rituals.
When considering robots, Kim suggests that the Confucian alternative of assigning rites — or what he calls role obligations — to robots is more appropriate than giving robots rights. The concept of rights is often adversarial and competitive, and potential conflict between humans and robots is concerning.
“Assigning role obligations to robots encourages teamwork, which triggers an understanding that fulfilling those obligations should be done harmoniously,” explains Kim. “Artificial intelligence (AI) imitates human intelligence, so for robots to develop as rites bearers, they must be powered by a type of AI that can imitate humans’ capacity to recognize and execute team activities — and a machine can learn that ability in various ways.”
Kim acknowledges that some will question why robots should be treated respectfully in the first place. “To the extent that we make robots in our image, if we don’t treat them well, as entities capable of participating in rites, we degrade ourselves,” he suggests.
Various non-natural entities — such as corporations — are considered people and even assume some Constitutional rights. In addition, humans are not the only species with moral and legal status; in most developed societies, moral and legal considerations preclude researchers from gratuitously using animals for lab experiments. More

Using an artificial intelligence algorithm, researchers at MIT and McMaster University have identified a new antibiotic that can kill a type of bacteria that is responsible for many drug-resistant infections.
If developed for use in patients, the drug could help to combat Acinetobacter baumannii, a species of bacteria that is often found in hospitals and can lead to pneumonia, meningitis, and other serious infections. The microbe is also a leading cause of infections in wounded soldiers in Iraq and Afghanistan.
“Acinetobacter can survive on hospital doorknobs and equipment for long periods of time, and it can take up antibiotic resistance genes from its environment. It’s really common now to find A. baumannii isolates that are resistant to nearly every antibiotic,” says Jonathan Stokes, a former MIT postdoc who is now an assistant professor of biochemistry and biomedical sciences at McMaster University.
The researchers identified the new drug from a library of nearly 7,000 potential drug compounds using a machine-learning model that they trained to evaluate whether a chemical compound will inhibit the growth of A. baumannii.
“This finding further supports the premise that AI can significantly accelerate and expand our search for novel antibiotics,” says James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering. “I’m excited that this work shows that we can use AI to help combat problematic pathogens such as A. baumannii.”
Collins and Stokes are the senior authors of the new study, which appears today in Nature Chemical Biology. The paper’s lead authors are McMaster University graduate students Gary Liu and Denise Catacutan and recent McMaster graduate Khushi Rathod.

Drug discovery
Over the past several decades, many pathogenic bacteria have become increasingly resistant to existing antibiotics, while very few new antibiotics have been developed.
Several years ago, Collins, Stokes, and MIT Professor Regina Barzilay (who is also an author on the new study), set out to combat this growing problem by using machine learning, a type of artificial intelligence that can learn to recognize patterns in vast amounts of data. Collins and Barzilay, who co-direct MIT’s Abdul Latif Jameel Clinic for Machine Learning in Health, hoped this approach could be used to identify new antibiotics whose chemical structures are different from any existing drugs.
In their initial demonstration, the researchers trained a machine-learning algorithm to identify chemical structures that could inhibit growth of E. coli. In a screen of more than 100 million compounds, that algorithm yielded a molecule that the researchers called halicin, after the fictional artificial intelligence system from “2001: A Space Odyssey.” This molecule, they showed, could kill not only E. coli but several other bacterial species that are resistant to treatment.
“After that paper, when we showed that these machine-learning approaches can work well for complex antibiotic discovery tasks, we turned our attention to what I perceive to be public enemy No. 1 for multidrug-resistant bacterial infections, which is Acinetobacter,” Stokes says.

To obtain training data for their computational model, the researchers first exposed A. baumannii grown in a lab dish to about 7,500 different chemical compounds to see which ones could inhibit growth of the microbe. Then they fed the structure of each molecule into the model. They also told the model whether each structure could inhibit bacterial growth or not. This allowed the algorithm to learn chemical features associated with growth inhibition.
Once the model was trained, the researchers used it to analyze a set of 6,680 compounds it had not seen before, which came from the Drug Repurposing Hub at the Broad Institute. This analysis, which took less than two hours, yielded a few hundred top hits. Of these, the researchers chose 240 to test experimentally in the lab, focusing on compounds with structures that were different from those of existing antibiotics or molecules from the training data.
Those tests yielded nine antibiotics, including one that was very potent. This compound, which was originally explored as a potential diabetes drug, turned out to be extremely effective at killing A. baumannii but had no effect on other species of bacteria including Pseudomonas aeruginosa, Staphylococcus aureus, and carbapenem-resistant Enterobacteriaceae.
This “narrow spectrum” killing ability is a desirable feature for antibiotics because it minimizes the risk of bacteria rapidly spreading resistance against the drug. Another advantage is that the drug would likely spare the beneficial bacteria that live in the human gut and help to suppress opportunistic infections such as Clostridium difficile.
“Antibiotics often have to be administered systemically, and the last thing you want to do is cause significant dysbiosis and open up these already sick patients to secondary infections,” Stokes says.
A novel mechanism
In studies in mice, the researchers showed that the drug, which they named abaucin, could treat wound infections caused by A. baumannii. They also showed, in lab tests, that it works against a variety of drug-resistant A. baumannii strains isolated from human patients.
Further experiments revealed that the drug kills cells by interfering with a process known as lipoprotein trafficking, which cells use to transport proteins from the interior of the cell to the cell envelope. Specifically, the drug appears to inhibit LolE, a protein involved in this process.
All Gram-negative bacteria express this enzyme, so the researchers were surprised to find that abaucin is so selective in targeting A. baumannii. They hypothesize that slight differences in how A. baumannii performs this task might account for the drug’s selectivity.
“We haven’t finalized the experimental data acquisition yet, but we think it’s because A. baumannii does lipoprotein trafficking a little bit differently than other Gram-negative species. We believe that’s why we’re getting this narrow spectrum activity,” Stokes says.
Stokes’ lab is now working with other researchers at McMaster to optimize the medicinal properties of the compound, in hopes of developing it for eventual use in patients.
The researchers also plan to use their modeling approach to identify potential antibiotics for other types of drug-resistant infections, including those caused by Staphylococcus aureus and Pseudomonas aeruginosa. More