Computers Math

The diagnosis of Parkinson’s disease has shaken many lives. More than 10 million people worldwide are living with it. There is no cure, but if symptoms are noticed early, the disease can be controlled. As Parkinson’s disease progresses, along with other symptoms speech changes.
Lithuanian researcher from Kaunas University of Technology (KTU), Rytis Maskeliūnas, together with colleagues from the Lithuanian University of Health Sciences (LSMU), tried to identify early symptoms of Parkinson’s disease using voice data.
Parkinson’s disease is usually associated with loss of motor function — hand tremors, muscle stiffness, or balance problems. According to Maskeliūnas, a researcher at KTU’s Department of Multimedia Engineering, as motor activity decreases, so does the function of the vocal cords, diaphragm, and lungs: “Changes in speech often occur even earlier than motor function disorders, which is why the altered speech might be the first sign of the disease.”
Expanding the AI language database
According to Professor Virgilijus Ulozas, at the Department of Ear, Nose, and Throat at the LSMU Faculty of Medicine, patients with early-stage of Parkinson’s disease, might speak in a quieter manner, which can also be monotonous, less expressive, slower, and more fragmented, and this is very difficult to notice by ear. As the disease progresses, hoarseness, stuttering, slurred pronunciation of words, and loss of pauses between words can become more apparent.
Taking these symptoms into account, a joint team of Lithuanian researchers has developed a system to detect the disease earlier.

“We are not creating a substitute for a routine examination of the patient — our method is designed to facilitate early diagnosis of the disease and to track the effectiveness of treatment,” says KTU researcher Maskeliūnas.
According to him, the link between Parkinson’s disease and speech abnormalities is not new to the world of digital signal analysis — it has been known and researched since the 1960s. However, as technology advances, it is becoming possible to extract more information from speech.
In their study, the researchers used artificial intelligence (AI) to analyse and assess speech signals, where calculations are done and diagnoses made in seconds rather than hours. This study is also unique — the results are tailored to the specifics of the Lithuanian language, in this way expanding the AI language database.
The algorithm will become a mobile app in the future
Speaking about the progress of the study, Kipras Pribuišis, lecturer at the Department of Ear, Nose, and Throat at the LSMU Faculty of Medicine, emphasises that it was only carried out on patients already diagnosed with Parkinson’s: “So far, our approach is able to distinguish Parkinson’s from healthy people using a speech sample. This algorithm is also more accurate than previously proposed.”
In a soundproof booth, a microphone was used to record the speech of healthy and Parkinson’s patients, and an artificial intelligence algorithm “learned” to perform signal processing by evaluating these recordings. The researchers highlight that the algorithm does not require powerful hardware and could be transferred to a mobile app in the future.
“Our results, which have already been published, have a very high scientific potential. Sure, there is still a long and challenging way to go before it can be applied in everyday clinical practice,” says Maskeliūnas.
According to the researcher, the next steps include increasing the number of patients to gather more data and determining whether the proposed algorithm is superior to alternative methods used for early diagnosis of Parkinson’s. In addition, it will be necessary to check whether the algorithm works well not only in laboratory-like environments but also in the doctor’s office or in the patient’s home. More

A research group has succeeded in measuring spin transport in a thin film of specific molecules — a material well-known in organic light emitting diodes — at room temperature. They found that this thin molecular film has a spin diffusion length of approximately 62 nm, a length that could have practical applications in developing spintronics technology. In addition, while electricity has been used to control spin transport in the past, the thin molecular film used in this study is photoconductive, allowing spin transport control using visible light.
Information processing devices — such as smartphones — are becoming more sophisticated because their information recording density constantly increases, thanks to advances in microfabrication technology. In recent years, however, the physical limits to processing are rapidly approaching, making further miniaturization difficult. Perhaps, though, the continued demand for more sophisticated technology requires a fundamental change in operating principles, so that faster, smaller, new devices can continue being made.
To meet this demand, a technology called spintronics — using the magnetic spin and the charge of electrons — is attracting attention as a key technology, that could unlock the next generation of advanced electronics. By aligning the direction of a magnetic spin and moving it like an electric current, it is possible to propagate information using very little power and generate less waste heat.
A research group, led by Professors Eiji Shikoh and Yoshio Teki of the Osaka Metropolitan University Graduate School of Engineering, has successfully measured spin transport, at room temperature, in a thin film of alpha-naphthyl diamine derivative (?NPD) molecules, a well-known material in organic light emitting diodes. This molecular thin film was found to have a spin diffusion length of approximately 62 nanometers, a distance that they expect can be used in practical applications.
To use spin transport to develop spintronics technology requires having a spin diffusion length in the tens of nanometer range at room temperature for accurate processing. The thin molecular film of ?NPD with a spin diffusion length of 62 nanometers — a long distance for molecular materials — was fabricated for this study by thermal evaporation in vacuum. While electricity has been used to control spin transport in the past, this new thin ?NPD molecular film is photoconductive, making it possible to control spin transport using visible light.
“For practical use, it will be necessary to uncover more details about spin injection and spin transport mechanisms through thin molecular films to control spin transport,” noted Professor Shikoh. “Further research is expected to lead to the realization of super energy-efficient devices that use small amounts of power and have little risk of overheating.” More

When two microscopic systems are entangled, their properties are linked to each other irrespective of the physical distance between the two. Manipulating this uniquely quantum phenomenon is what allows for quantum cryptography, communication, and computation. While parallels have been drawn between quantum entanglement and the classical physics of heat, new research demonstrates the limits of this comparison. Entanglement is even richer than we have given it credit for. T
The power of the second law
The second law of thermodynamics is often considered to be one of only a few physical laws that is absolutely and unquestionably true. The law states that the amount of ‘entropy’ — a physical property — of any closed system can never decrease. It adds an ‘arrow of time’ to everyday occurrences, determining which processes are reversible and which are not. It explains why an ice cube placed on a hot stove will always melt, and why compressed gas will always fly out of its container (and never back in) when a valve is opened to the atmosphere.
Only states of equal entropy and energy can be reversibly converted from one to the other. This reversibility condition led to the discovery of thermodynamic processes such as the (idealised) Carnot cycle, which poses an upper limit to how efficiently one can convert heat into work, or the other way around, by cycling a closed system through different temperatures and pressures. Our understanding of this process underpinned the rapid economic development during the Western Industrial Revolution.
Quantum entropy
The beauty of the second law of thermodynamics is its applicability to any macroscopic system, regardless of the microscopic details. In quantum systems, one of these details may be entanglement: a quantum connection that makes separated components of the system share properties. Intriguingly, quantum entanglement shares many profound similarities with thermodynamics, even though quantum systems are mostly studied in the microscopic regime. Scientists have uncovered a notion of ‘entanglement entropy’ that precisely mimics the role of the thermodynamical entropy, at least for idealised quantum systems that are perfectly isolated from their surroundings.

“Quantum entanglement is a key resource that underlies much of the power of future quantum computers. To make effective use of it, we need to learn how to manipulate it,” says quantum information researcher Ludovico Lami. A fundamental question became whether entanglement can always be reversibly manipulated, in direct analogy to the Carnot cycle. Crucially, this reversibility would need to hold, at least in theory, even for noisy (‘mixed’) quantum systems that have not been kept perfectly isolated from their environment.
It was conjectured that a ‘second law of entanglement’ could be established, embodied in a single function that would generalise the entanglement entropy and govern all entanglement manipulation protocols. This conjecture featured in a famous list of open problems in quantum information theory.
No second law of entanglement
Resolving this long-standing open question, research carried out by Lami (previously at University of Ulm and currently at QuSoft and the University of Amsterdam) and Bartosz Regula (University of Tokyo) demonstrates that manipulation of entanglement is fundamentally irreversible, putting to rest any hopes of establishing a second law of entanglement. This new result relies on the construction of a particular quantum state which is very ‘expensive’ to create using pure entanglement. Creating this state will always result in a loss of some of this entanglement, as the invested entanglement cannot be fully recovered. As a result, it is inherently impossible to transform this state into another and back again. The existence of such states was previously unknown.
Because the approach used here does not presuppose what exact transformation protocols are used, it rules out the reversibility of entanglement in all possible settings. It applies to all protocols, assuming they don’t generate new entanglement themselves. Lami explains: “Using entangling operations would be like running a distillery in which alcohol from elsewhere is secretly added to the beverage.”
Lami: “We can conclude that no single quantity, such as the entanglement entropy, can tell us everything there is to know about the allowed transformations of entangled physical systems. The theory of entanglement and thermodynamics are thus governed by fundamentally different and incompatible sets of laws.”
This may mean that describing quantum entanglement is not as simple as scientists had hoped. Rather than being a drawback, however, the vastly greater complexity of the theory of entanglement compared to the classical laws of thermodynamics may allow us to use entanglement to achieve feats that would otherwise be completely inconceivable. “For now, what we know for certain is that entanglement hides an even richer and more complicated structure that we had given it credit for,” concludes Lami. More

Researchers have made a significant leap forward in developing insect-sized jumping robots capable of performing tasks in the small spaces often found in mechanical, agricultural and search-and-rescue settings.
A new study led by mechanical sciences and engineering professor Sameh Tawfick demonstrates a series of click beetle-sized robots small enough to fit into tight spaces, powerful enough to maneuver over obstacles and fast enough to match an insect’s rapid escape time.
The findings are published in the Proceedings of the National Academy of Sciences.
Researchers at the U. of I. and Princeton University have studied click beetle anatomy, mechanics and evolution over the past decade. A 2020 study found that snap buckling — the rapid release of elastic energy — of a coiled muscle within a click beetle’s thorax is triggered to allow them to propel themselves in the air many times their body length, as a means of righting themselves if flipped onto their backs.
“One of the grand challenges of small-scale robotics is finding a design that is small, yet powerful enough to move around obstacles or quickly escape dangerous settings,” Tawfick said.
In the new study, Tawfick and his team used tiny coiled actuators — analogous to animal muscles — that pull on a beam-shaped mechanism, causing it to slowly buckle and store elastic energy until it is spontaneously released and amplified, propelling the robots upward.

“This process, called a dynamic buckling cascade, is simple compared to the anatomy of a click beetle,” Tawfick said. “However, simple is good in this case because it allows us to work and fabricate parts at this small scale.”
Guided by biological evolution and mathematical models, the team built and tested four device variations, landing on two configurations that can successfully jump without manual intervention.
“Moving forward, we do not have a set approach on the exact design of the next generation of these robots, but this study plants a seed in the evolution of this technology — a process similar to biologic evolution,” Tawfick said.
The team envisions these robots accessing tight spaces to help perform maintenance on large machines like turbines and jet engines, for example, by taking pictures to identify problems.
“We also imagine insect-scale robots being useful in modern agriculture,” Tawfick said. “Scientists and farmers currently use drones and rovers to monitor crops, but sometimes researchers need a sensor to touch a plant or to capture a photograph of a very small-scale feature. Insect-scale robots can do that.”
Researchers from the University of Birmingham, UK; Oxford University; and the University of Texas at Dallas also participated in this research.
The Defense Advanced Research Projects Agency, the Toyota Research Institute North America, the National Science Foundation and The Royal Society supported this study. More

If you have young children, you’re likely worried about how much time they spend staring at a screen, be it a tablet, phone, computer, or television. You probably also want to know how screen time affects your child’s development and wonder whether there’s anything you can do to balance out any negative effects. New research from Japan indicates that more screen time at age 2 is associated with poorer communication and daily living skills at age 4 — but when kids also play outdoors, some of the negative effects of screen time are reduced.
In the study, which will be published in March in JAMA Pediatrics, the researchers followed 885 children from 18 months to 4 years of age. They looked at the relationship between three key features: average amount of screen time per day at age 2, amount of outdoor play at age 2 years 8 months, and neurodevelopmental outcomes — specifically, communication, daily living skills, and socialization scores according to a standardized assessment tool called Vineland Adaptive Behavior Scale-II — at age 4.
“Although both communication and daily living skills were worse in 4-year-old children who had had more screen time at aged 2, outdoor play time had very different effects on these two neurodevelopmental outcomes,” explains Kenji J. Tsuchiya, Professor at Osaka University and lead author of the study. “We were surprised to find that outdoor play didn’t really alter the negative effects of screen time on communication — but it did have an effect on daily living skills.”
Specifically, almost one-fifth of the effects of screen time on daily living skills were mediated by outdoor play, meaning that increasing outdoor play time could reduce the negative effects of screen time on daily living skills by almost 20%. The researchers also found that, although it was not linked to screen time, socialization was better in 4-year-olds who had spent more time playing outside at 2 years 8 months of age.
“Taken together, our findings indicate that optimizing screen time in young children is really important for appropriate neurodevelopment,” says Tomoko Nishimura, senior author of the study. “We also found that screen time is not related to social outcomes, and that even if screen time is relatively high, encouraging more outdoor play time might help to keep kids healthy and developing appropriately.”
These results are particularly important given the recent COVID-19-related lockdowns around the world, which have generally led to more screen time and less outdoor time for children. Because the use of digital devices is difficult to avoid even in very young children, further research looking at how to balance the risks and benefits of screen time in young children is eagerly awaited. More