Computers Math

Imagine you’re a PhD student with a fluorescent microscope and a sample of live bacteria. What’s the best way use these resources to obtain detailed observations of bacterial division from the sample?
You may be tempted to forgo food and rest, to sit at the microscope non-stop and acquire images when bacterial finally division starts. (It can take hours for one bacterium to divide!) It’s not as crazy as it sounds, since manual detection and acquisition control is widespread in many of the sciences.
Alternatively, you may want to set the microscope to take images indiscriminately and as often as possible. But excessive light depletes the fluorescence from the sample faster and can prematurely destroy living samples. Plus, you’d generate many uninteresting images, since only a few would contain images of dividing bacteria.
Another solution would be to use artificial intelligence to detect precursors to bacterial division and use these to automatically update the microscope’s control software to take more pictures of the event.
Drum roll… yes, EPFL biophysicists have indeed found a way to automate microscope control for imaging biological events in detail while limiting stress on the sample, all with the help of artificial neural networks. Their technique works for bacterial cell division, and for mitochondrial division. The details of their intelligent microscope are described in Nature Methods.
“An intelligent microscope is kind of like a self-driving car. It needs to process certain types of information, subtle patterns that it then responds to by changing its behavior,” explains principal investigator Suliana Manley of EPFL’s Laboratory of Experimental Biophysics. “By using a neural network, we can detect much more subtle events and use them to drive changes in acquisition speed.”
Manley and her colleagues first solved how to detect mitochondrial division, more difficult than for bacteria such as C. crescentus. Mitochondrial division is unpredictable, since it occurs infrequently, and can happen almost anywhere within the mitochondrial network at any moment. But the scientists solved the problem by training the neural network to look out for mitochondrial constrictions, a change in shape of mitochondria that leads to division, combined with observations of a protein known to be enriched at sites of division.
When both constrictions and protein levels are high, the microscope switches into high-speed imaging to capture many images of division events in detail. When constriction and protein levels are low, the microscope then switches to low-speed imaging to avoid exposing the sample to excessive light.
With this intelligent fluorescent microscope, the scientists showed that they could observe the sample for longer compared to standard fast imaging. While the sample was more stressed compared to standard slow imaging, they were able to obtain more meaningful data.
“The potential of intelligent microscopy includes measuring what standard acquisitions would miss,” Manley explains. “We capture more events, measure smaller constrictions, and can follow each division in greater detail.”
The scientists are making the control framework available as an open source plug-in for the open microscope software Micro-Manager, with the aim of allowing other scientists to integrate artificial intelligence into their own microscopes. More

Parents and pundits may no longer argue that gamers are indulging in brainless activities in front of their screens. And gamers may finally feel a sense of vindication.
Kyoto University and BonBon Inc, a Kyoto-based healthcare-related IT company, have now teamed up to show that multiple cognitive abilities may be empirically measured from a complex game experience depending on the game’s design.
“Video games can be made to engage and characterize distinct cognitive abilities while still retaining the entertainment value that popular titles offer,” says Tomihiro Ono, lead author of the joint study in Scientific Reports.
He adds, “For example, we found that there are in-game micro-level connections such as between stealth behavior and abstract thinking, aiming and attention, and targeting and visual discrimination.”
To make these connections between complex gameplay and interpretable cognitive characteristics, the team combined the use of data from Potion, a 3-D action video game by BonBon Inc, and WebCNP, conventional cognitive tests maintained by the University of Pennsylvania.
Although existing literature and general beliefs regarding similar action video games already suggest the advantage that younger males may have over other demographic groups, the researchers did not expect to obtain measurements reflecting stark differences even after accounting for gaming experience.
“The lack of a connection between cognitive abilities and video game elements in aged players came as a surprise,” Ono notes.
To attain more scientific insight into the psyche of gamers, such as in why computer games have positive influences on some players, the researchers posit that studies using games ought to avoid one-size-fits-all approaches, as demographic factors and game experience can be assumed to affect results.
“We think that a granular understanding of cognitive engagement in video games has potential in benefitting such research areas as psychiatry, psychology, and education,” concludes the author.
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Game engines were originally developed to build imaginary worlds for entertainment. However, these same engines can be used to build copies of real environments, that is, digital twins. Researchers from Osaka University have found a way to use the images that were automatically generated by digital city twins to train deep learning models that can efficiently analyze images of real cities and accurately separate the buildings that appear in them.
A convolutional neural network is a deep learning neural network designed for processing structured arrays of data such as images. Such advancements in deep learning have fundamentally changed the way tasks, like architectural segmentation, are performed. However, an accurate deep convolutional neural network (DCNN) model needs a large volume of labeled training data and labeling these data can be a slow and extremely expensive manual undertaking.
To create the synthetic digital city twin data, the investigators used a 3D city model from the PLATEAU platform, which contains 3D models of most Japanese cities at an extremely high level of detail. They loaded this model into the Unity game engine and created a camera setup on a virtual car, which drove around the city and acquired the virtual data images under various lighting and weather conditions. The Google Maps API was then used to obtain real street-level images of the same study area for the experiments.
The researchers found that the digital city twin data leads to better results than purely virtual data with no real-world counterpart. Furthermore, adding synthetic data to a real dataset improves segmentation accuracy. However, most importantly, the investigators found that when a certain fraction of real data is included in the digital city twin synthetic dataset, the segmentation accuracy of the DCNN is boosted significantly. In fact, its performance becomes competitive with that of a DCNN trained on 100% real data. “These results reveal that our proposed synthetic dataset could potentially replace all the real images in the training set,” says Tomohiro Fukuda, the corresponding author of the paper.
Automatically separating out the individual building facades that appear in an image is useful for construction management and architecture design, large-scale measurements for retrofits and energy analysis, and even visualizing building facades that have been demolished. The system was tested on multiple cities, demonstrating the proposed framework’s transferability. The hybrid dataset of real and synthetic data yields promising prediction results for most modern architectural styles. This makes it a promising approach for training DCNNs for architectural segmentation tasks in the future — without the need for costly manual data annotation.
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All magnets — from the simple souvenirs hanging on your refrigerator to the discs that give your computer memory to the powerful versions used in research labs — contain spinning quasiparticles called magnons. The direction one magnon spins can influence that of its neighbor, which affects the spin of its neighbor, and so on, yielding what are known as spin waves. Information can potentially be transmitted via spin waves more efficiently than with electricity, and magnons can serve as “quantum interconnects” that “glue” quantum bits together into powerful computers.
Magnons have enormous potential, but they are often difficult to detect without bulky pieces of lab equipment. Such setups are fine for conducting experiments, but not for developing devices, said Columbia researcher Xiaoyang Zhu, such as magnonic devices and so-called spintronics. Seeing magnons can be made much simpler, however, with the right material: a magnetic semiconductor called chromium sulfide bromide (CrSBr) that can be peeled into atom-thin, 2D layers, synthesized in Department of Chemistry professor Xavier Roy’s lab.
In a new article in Nature, Zhu and collaborators at Columbia, the University of Washington, New York University, and Oak Ridge National Laboratory show that magnons in CrSBr can pair up with another quasiparticle called an exciton, which emits light, offering the researchers a means to “see” the spinning quasiparticle.
As they perturbed the magnons with light, they observed oscillations from the excitons in the near-infrared range, which is nearly visible to the naked eye. “For the first time, we can see magnons with a simple optical effect,” Zhu said.
The results may be viewed as quantum transduction, or the conversion of one “quanta” of energy to another, said first author Youn Jun (Eunice) Bae, a postdoc in Zhu’s lab. The energy of excitons is four orders of magnitude larger than that of magnons; now, because they pair together so strongly, we can easily observe tiny changes in the magnons, Bae explained. This transduction may one day enable researchers to build quantum information networks that can take information from spin-based quantum bits — which generally need to be located within millimeters of each other — and convert it to light, a form of energy that can transfer information up to hundreds of miles via optical fibers
The coherence time — how long the oscillations can last — was also remarkable, Zhu said, lasting much longer than the five-nanosecond limit of the experiment. The phenomenon could travel over seven micrometers and persist even when the CrSBr devices were made of just two atom-thin layers, raising the possibility of building nano-scale spintronic devices. These devices could one day be more efficient alternatives to today’s electronics. Unlike electrons in an electrical current that encounter resistance as they travel, no particles are actually moving in a spin wave.
The work was supported by Columbia’s NSF-funded Materials Research Science and Engineering Center (MRSEC), with the material created in the DOE-funded Energy Frontier Research Center (EFRC). From here, the researchers plan to explore CrSBr’s quantum information potential, as well as other material candidates. “In the MRSEC and EFRC, we are exploring the quantum properties of several 2D materials that you can stack like papers to create all kinds of new physical phenomena,” Zhu said.
For example, if magnon-exciton coupling can be found in other kinds of magnetic semiconductors with slightly different properties than CrSBr, they might emit light in a wider range of colors. “We’re assembling the toolbox to construct new devices with customizable properties,” Zhu said.
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Materials provided by Columbia University. Original written by Ellen Neff. Note: Content may be edited for style and length. More

Imagine you have a group of 30 children who want to play soccer. You would like to divide them into two teams, so they can practice their skills and learn from their coaches to become better players.
But what is the most effective way for them to improve: Should you group the children according to skill level, with all of the most skilled players in one group and the rest of the players in the other group? Or, should you divide them into two equal teams by talent and skill?
For a fresh approach to this age-old question in grouping theory, a researcher from the University of Rochester, along with his childhood friend, an education professor at the University of Nevada, Las Vegas, turned to math.
“The selection and grouping of individuals for training purposes is extremely common in our society,” says Chad Heatwole, a professor of neurology at the University of Rochester Medical Center and the director of Rochester’s Center for Health + Technology (CHeT). “There is a historic and ongoing rigorous debate regarding the best way to group students for the purpose of instruction.”
In a paper published in the journal Education Practice and Theory, the research team — which also includes Peter Wiens, an associate professor of teaching and learning at the University of Nevada, Las Vegas, and Christine Zizzi, a director at CHeT — developed, for the first time, a mathematical approach to grouping. The approach compares different grouping methods, selecting the optimal way to group individuals for teacher-led instruction. The research has broad implications in education, as well as in economics, music, medicine, and sports.
“Our solution was to look at this through a purely mathematical lens, evaluating for the greatest good of the entire sample,” Heatwole says. “To our knowledge, this novel mathematical approach has never been described or utilized in this way.”
Two approaches in grouping theory More

This encouraging response may actually do more harm than good to children’s math performance, according to a new study by the University of Georgia.
Co-conducted by Michael Barger, an assistant professor in the Mary Frances Early College of Education’s Department of Educational Psychology, the study found that encouraging children with responses related to their personal traits or innate abilities may dampen their math motivation and achievement over time.
Parents who make comments linking their children’s performance to personal attributes like intelligence (e.g., “You’re so smart” or “Math just isn’t your thing”) are using what’s referred to as person responses. In contrast, parents who link their children’s actions, such as effort or strategy use, to their performance (e.g., “You worked hard” or “What might be useful next time you have a math test?”) are using process responses.
“Person-focused praise sounds good on its face, but ultimately, it might undermine students’ motivation if they run into challenges,” said Barger. “Because if you run into challenges after being told you’re so smart, you might think, ‘Maybe they were wrong.’ We also know that people tend to think about math as something that some people can do and others can’t, and that language is pretty common, whether it’s among parents or teachers, even with young kids.”
Praising strategy and effort
For the study, researchers asked more than 500 parents to report on how they respond to their children’s math performance and their math beliefs and goals. Students were assessed in two waves across a year to measure their math motivation and achievement. More

A groundbreaking mathematical equation has been discovered, which could transform medical procedures, natural gas extraction, and plastic packaging production in the future.
The new equation, developed by scientists at the University of Bristol, indicates that diffusive movement through permeable material can be modelled exactly for the very first time. It comes a century after world-leading physicists Albert Einstein and Marian von Smoluchowski derived the first diffusion equation and marks important progress in representing motion for a wide range of entities from microscopic particles and natural organisms to human-made devices.
Until now, scientists looking at particle motion through porous materials such as biological tissues, polymers, various rocks and sponges, have had to rely on approximations or incomplete perspectives.
The findings, published today in the journal Physical Review Research, provide a novel technique presenting exciting opportunities in a diverse range of settings including health, energy, and the food industry.
Lead author Toby Kay, who is completing a PhD in Engineering Mathematics, said: “This marks a fundamental step forward since Einstein and Smoluchowski’s studies on diffusion. It revolutionises the modelling of diffusing entities through complex media of all scales, from cellular components and geological compounds to environmental habitats.
“Previously, mathematical attempts to represent movement through environments scattered with objects that hinder motion, known as permeable barriers, have been limited. By solving this problem, we are paving the way for exciting advances in many different sectors because permeable barriers are routinely encountered by animals, cellular organisms and humans.”
Creativity in mathematics takes different forms and one of these is the connection between different levels of description of a phenomenon. In this instance, by representing random motion in a microscopic fashion and then subsequently zooming out to describe the process macroscopically, it was possible to find the new equation.
Further research is needed to apply this mathematical tool to experimental applications, which could improve products and services. For example, being able to model accurately the diffusion of water molecules through biological tissue will advance the interpretation of diffusion-weighted MRI (Magnetic Resonance Imaging) readings. It could also offer more accurate representation of air spreading through food packaging materials, helping to determine shelf life and contamination risk. In addition, quantifying the behaviour of foraging animals interacting with macroscopic barriers, such as fences and roads, could provide better predictions on the consequence of climate change for conservation purposes.
The use of geolocators, mobile phones, and other sensors has seen the tracking revolution generate movement data of ever-increasing quantity and quality over the past 20 years. This has highlighted the need for more sophisticated modelling tools to represent the movement of wide-ranging entities in their environment, from natural organisms to human-made devices.
Senior author Dr Luca Giuggioli, Associate Professor in Complexity Sciences at the University of Bristol, said: “This new fundamental equation is another example of the importance of constructing tools and techniques to represent diffusion when space is heterogeneous, that is when the underlying environment changes from location to location.
“It builds on another long-awaited resolution in 2020 of a mathematical conundrum to describe random movement in confined space. This latest discovery is a further significant step forward in improving our understanding of motion in all its shapes and forms — collectively termed the mathematics of movement — which has many exciting potential applications.”
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Key studies in the last decade have shown that the gut microbiome, the collection of hundreds of bacterial species that live in the human digestive system, influences neural development, response to cancer immunotherapies, and other aspects of health. But these communities are complex and without systematic ways to study the constituents, the exact cells and molecules linked with certain diseases remain a mystery.
Stanford University researchers have built the most complex and well-defined synthetic microbiome, creating a community of over 100 bacterial species that was successfully transplanted into mice. The ability to add, remove, and edit individual species will allow scientists to better understand the links between the microbiome and health, and eventually develop first-in-class microbiome therapies.
Many key microbiome studies have been done using fecal transplants, which introduce the entire, natural microbiome from one organism to another. While scientists routinely silence a gene or remove a protein from a specific cell or even an entire mouse, there is no such set of tools to remove or modify one species among the hundreds in a given fecal sample.
“So much of what we know about biology, we wouldn’t know if it weren’t for the ability to manipulate complex biological systems piecewise,” said Michael Fischbach, Institute Scholar at Sarafan ChEM-H and corresponding author on the study, published in Cell on Sept. 6.
Fischbach, who is an associate professor of bioengineering and of microbiology and immunology, and others saw one solution: Build a microbiome from scratch by growing individually and then mixing its constituent bacteria.
Building the ark
Each cell in the microbiome occupies a specific functional niche, performing reactions that break down and build up molecules. To build a microbiome, the team had to ensure that the final mixture was not only stable, maintaining a balance without any single species overpowering the rest, but also functional, performing all the actions of a complete, natural microbiome. Selecting species to include in their synthetic community was also difficult given the natural variation across individuals; two people selected at random share less than half of their microbial genes. More