Computers Math

Research led by the University of Exeter and Kent and Medway NHS and Social Care Partnership Trust, published in Age and Ageing, assessed a new tool designed to calculate which medicines are more likely to experience adverse anticholinergic effects on the body and brain. These complications can occur from many -prescription and over-the-counter drugs which affects the brain by blocking a key neurotransmitter called acetylcholine. Many medicines, including some bladder medications, anti-depressants, medications for stomach and Parkinson’s disease have some degree of anticholinergic effect. They are commonly taken by older people.
Anticholinergic side effects include confusion, blurred vision, dizziness, falls and a decline in brain function. Anticholinergic effects may also increase risks of falls and may be associated with an increase in mortality. They have also been linked to a higher risk of dementia when used long term.
Now, researchers have developed a tool to calculate harmful effects of medicines using artificial intelligence. The team created a new online tool, International Anticholinergic Cognitive Burden Tool (IACT), is uses natural language processing which is an artificial intelligence methdolody and chemical structure analysis to identify medications that have anticholinergic effect.
The tool is the first to incorporate a machine learning technique, to develop an automatically updated tool available on a website portal. The anticholinergic burden is assessed by assigning a score based on reported adverse events and aligning closely with the chemical structure of the drug being considered for prescription, resulting in a more accurate and up-to-date scoring system than any previous system. Ultimately, after further research and modelling with real world patient data the tool developed could help to support prescribing reducing risks form common medicines.
Professor Chris Fox, at the University of Exeter, is one of the study authors. He said:: “Use of medicines with anticholinergic effects can have significant harmful effects for example falls and confusion which are avoidable, we urgently need to reduce the harmful side effects as this can leads to hospitalisation and death. This new tool provides a promising avenue towards a more tailored personalised medicine approach, of ensuring the right person gets a safe and effective treatment whilst avoiding unwanted anticholinergic effects.”
The team surveyed 110 health professionals, including pharmacists and prescribing nurses. Of this group, 85 per cent said they would use a tool to assess risk of anticholinergic side effects, if available. The team also gathered usability feedback to help improve the tool further.
Dr Saber Sami, at the University of East Anglia, said: “Our tool is the first to use innovative artificial intelligence technology in measures of anticholinergic burden — ultimately, once further research has been conducted the tool should support pharmacists and prescribing health professionals in finding the best treatment for patients.”
Professor Ian Maidment, from Aston University, said: “I have been working in this area for over 20 years. Anti-cholinergic side-effects can be very debilitating for patients. We need better ways to assess these side-effects.”
The research team includes collaboration with AKFA University Medical School, Uzbekistan, and the Universities of East Anglia, Aston, Kent and Aberdeen. They aim to continue development of the tool with the aim that it can be deployed in day-to-day practice which this study supports.
Story Source:
Materials provided by University of Exeter. Note: Content may be edited for style and length. More

Abrahamic texts treat slithering as a special indignity visited on the wicked serpent, but evolution may draw a more continuous line through the motion of swimming microbes, wriggling worms, skittering spiders and walking horses.
A new study found that all of these kinds of motion are well represented by a single mathematical model.
“This didn’t come out of nowhere — this is from our real robot data,” said Dan Zhao, first author of the study in the Proceedings of the National Academy of Sciences and a recent Ph.D. graduate in mechanical engineering at the University of Michigan.
“Even when the robot looks like it’s sliding, like its feet are slipping, its velocity is still proportional to how quickly it’s moving its body.”
Unlike the dynamic motion of gliding birds and sharks and galloping horses — where speed is driven, at least in part, by momentum — every bit of speed for ants, centipedes, snakes and swimming microbes is driven by changing the shape of the body. This is known as kinematic motion.
The expanded understanding of kinematic motion could change the way roboticists think about programming many-limbed robots, opening new possibilities for walking planetary rovers, for instance. More

Microbial populations may be small but they are surprisingly complex, making interactions with their surrounding environment difficult to study. But now, researchers from Japan have discovered that machine learning can provide the tools to do just that. In a study published this month in eLife, researchers from the University of Tsukuba have revealed that machine learning can be applied to bacterial population growth to discover how it relates to variations in their environment.
The dynamics of microbe populations are usually represented by growth curves. Typically, three parameters taken from these curves are used to evaluate how microbial populations fit with their environment: lag time, growth rate, and saturated population size (or carrying capacity). These three parameters are probably linked; trade-offs have been observed between the growth rate and either the lag time or population size within species, and with related changes in the saturated population size and growth rate among genetically diverse strains.
“Two questions remained: are these three parameters affected by environmental diversity, and if so, how?” says senior author of the study, Professor Bei-Wen Ying. “To answer these, we used data-driven approaches to investigate the growth strategy of bacteria.”
The researchers built a large dataset that reflected the dynamics of Escherichia coli populations under a wide variety of environmental conditions, using almost a thousand combinations of growth media composed from 44 chemical compounds under controlled lab conditions. They then analyzed the big data for the relationships between the growth parameters and the combinations of media using machine learning (ML). ML algorithms built a model based on sample data to make predictions or decisions without being specifically programmed to do so.
The analysis revealed that for bacterial growth, the decision-making components were distinct among different growth phases, e.g., serine, sulfate, and glucose for growth delay (lag), growth rate, and maximum growth (saturation), respectively. The results of additional simulations and analyses showed that branched-chain amino acids likely act as ubiquitous coordinators for bacterial population growth conditions.
“Our results also revealed a common and simple strategy of risk diversification in conditions where the bacteria experienced excess resources or starvation, which makes sense in both an evolutionary and ecological context,” says Professor Ying.
The results of this study have revealed that exploring the world of microorganisms with data-driven approaches can provide new insights that were previously unattainable via traditional biological experiments. This research shows that the ML-assisted approach, although still an emerging technology that will need to be developed in terms of its biological reliability and accessibility, could open new avenues for applications in the life sciences, especially microbiology and ecology.
The study was funded by Japan Society for the Promotion of Science 21K19815 and 19H03215.
Story Source:
Materials provided by University of Tsukuba. Note: Content may be edited for style and length. More

Appropriately balancing a videogame’s difficulty is essential to provide players with a pleasant experience. In a recent study, Korean scientists developed a novel approach for dynamic difficulty adjustment where the players’ emotions are estimated using in-game data, and the difficulty level is tweaked accordingly to maximize player satisfaction. Their efforts could contribute to balancing the difficulty of games and making them more appealing to all types of players.
Difficulty is a tough aspect to balance in video games. Some people prefer videogames that present a challenge whereas others enjoy an easy experience. To make this process easier, most developers use ‘dynamic difficulty adjustment (DDA).’ The idea of DDA is to adjust the difficulty of a game in real time according to player performance. For example, if player performance exceeds the developer’s expectations for a given difficulty level, the game’s DDA agent can automatically raise the difficulty to increase the challenge presented to the player. Though useful, this strategy is limited in that only player performance is taken into account, not how much fun they are actually having.
In a recent study published in Expert Systems With Applications, a research team from the Gwangju Institute of Science and Technology in Korea decided to put a twist on the DDA approach. Instead of focusing on the player’s performance, they developed DDA agents that adjusted the game’s difficulty to maximize one of four different aspects related to a player’s satisfaction: challenge, competence, flow, and valence. The DDA agents were trained via machine learning using data gathered from actual human players, who played a fighting game against various artificial intelligences (AIs) and then answered a questionnaire about their experience.
Using an algorithm called Monte-Carlo tree search, each DDA agent employed actual game data and simulated data to tune the opposing AI’s fighting style in a way that maximized a specific emotion, or ‘affective state.’ “One advantage of our approach over other emotion-centered methods is that it does not rely on external sensors, such as electroencephalography,” comments Associate Professor Kyung-Joong Kim, who led the study. “Once trained, our model can estimate player states using in-game features only.”
The team verified — through an experiment with 20 volunteers — that the proposed DDA agents could produce AIs that improved the players’ overall experience, no matter their preference. This marks the first time that affective states are incorporated directly into DDA agents, which could be useful for commercial games. “Commercial game companies already have huge amounts of player data. They can exploit these data to model the players and solve various issues related to game balancing using our approach,” remarks Associate Professor Kim. Worth noting is that this technique also has potential for other fields that can be ‘gamified,’ such as healthcare, exercise, and education.
This paper was made available online on June 3, 2022, and will be published in Volume 205 of the journal on November 1, 2022.
Story Source:
Materials provided by GIST (Gwangju Institute of Science and Technology). Note: Content may be edited for style and length. More

Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming. One promising new strategy is to use computational models, which offer a potentially faster and cheaper way to identify new drugs.
A new study from MIT reveals the potential and limitations of one such computational approach. Using protein structures generated by an artificial intelligence program called AlphaFold, the researchers explored whether existing models could accurately predict the interactions between bacterial proteins and antibacterial compounds. If so, then researchers could begin to use this type of modeling to do large-scale screens for new compounds that target previously untargeted proteins. This would enable the development of antibiotics with unprecedented mechanisms of action, a task essential to addressing the antibiotic resistance crisis.
However, the researchers, led by James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering, found that these existing models did not perform well for this purpose. In fact, their predictions performed little better than chance.
“Breakthroughs such as AlphaFold are expanding the possibilities for in silico drug discovery efforts, but these developments need to be coupled with additional advances in other aspects of modeling that are part of drug discovery efforts,” Collins says. “Our study speaks to both the current abilities and the current limitations of computational platforms for drug discovery.”
In their new study, the researchers were able to improve the performance of these types of models, known as molecular docking simulations, by applying machine-learning techniques to refine the results. However, more improvement will be necessary to fully take advantage of the protein structures provided by AlphaFold, the researchers say.
Collins is the senior author of the study, which appears today in the journal Molecular Systems Biology. MIT postdocs Felix Wong and Aarti Krishnan are the lead authors of the paper. More

The sense of smell is one of the basic senses of animal species. It is critical to finding food, realizing attraction, and sensing danger. Humans detect smells, or odorants, with olfactory receptors expressed in olfactory nerve cells. These olfactory impressions of odorants on nerve cells are associated with their molecular features and physicochemical properties. This makes it possible to tailor odors to create an intended odor impression. Current methods only predict olfactory impressions from the physicochemical features of odorants. But, that method cannot predict the sensing data, which is indispensable for creating smells.
To tackle this issue, scientists from Tokyo Institute of Technology (Tokyo Tech) have employed the innovative strategy of solving the inverse problem. Instead of predicting the smell from molecular data, this method predicts molecular features based on the odor impression. This is achieved using standard mass spectrum data and machine learning (ML) models. “We used a machine-learning-based odor predictive model that we had previously developed to obtain the odor impression. Then we predicted the mass spectrum from odor impression inversely based on the previously developed forward model,” explains Professor Takamichi Nakamoto, the leader of the research effort by Tokyo Tech. The findings have been published in PLoS One.
The mass spectra of odor mixtures is obtained by a linear combination of the mass spectra of single components. This simple method allows for the quick preparation of the predicted spectra of odor mixtures and can also predict the required mixing ratio, an important part of the recipe for new odor preparation. “For example, we show which molecules give the mass spectrum of apple flavor with enhanced ‘fruit’ and ‘sweet’ impressions. Our analysis method shows that combinations of either 59 or 60 molecules give the same mass spectrum as the one obtained from the specified odor impression. With this information, and the correct mixing ratio needed for a certain impression, we could theoretically prepare the desired scent,” highlights Prof. Nakamoto.
This novel method described in this study can provide highly accurate predictions of the physicochemical properties of odor mixtures, as well as the mixing ratios required to prepare them, thereby opening the door to endless tailor-made fragrances.
Story Source:
Materials provided by Tokyo Institute of Technology. Note: Content may be edited for style and length. More

An international team led by researchers at the RIKEN Cluster for Pioneering Research (CPR) has engineered a system for creating remote controlled cyborg cockroaches, equipped with a tiny wireless control module that is powered by a rechargeable battery attached to a solar cell. Despite the mechanic devices, ultrathin electronics and flexible materials allow the insects to move freely. These achievements, reported in the scientific journal npj Flexible Electronics on September 5, will help make the use of cyborg insects a practical reality.
Researchers have been trying to design cyborg insects — part insect, part machine — to help inspect hazardous areas or monitor the environment. However, for the use of cyborg insects to be practical, handlers must be able to control them remotely for long periods of time. This requires wireless control of their leg segments, powered by a tiny rechargeable battery. Keeping the battery adequately charged is fundamental — nobody wants a suddenly out-of-control team of cyborg cockroaches roaming around. While it’s possible to build docking stations for recharging the battery, the need to return and recharge could disrupt time-sensitive missions. Therefore, the best solution is to include an on-board solar cell that can continuously ensure that the battery stays charged.
All of this is easier said than done. To successfully integrate these devices into a cockroach that has limited surface area required the research team to develop a special backpack, ultrathin organic solar cell modules, and an adhesion system that keeps the machinery attached for long periods of time while also allowing natural movements.
Led by Kenjiro Fukuda, RIKEN CPR, the team experimented with Madagascar cockroaches, which are approximately 6 cm long. They attached the wireless leg-control module and lithium polymer battery to the top of the insect on the thorax using a specially designed backpack, which was modeled after the body of a model cockroach. The backpack was 3D printed with an elastic polymer and conformed perfectly to the curved surface of the cockroach, allowing the rigid electronic device to be stably mounted on the thorax for more than a month.
The ultrathin 0.004 mm thick organic solar cell module was mounted on the dorsal side of the abdomen. “The body-mounted ultrathin organic solar cell module achieves a power output of 17.2 mW, which is more than 50 times larger than the power output of current state-of-the art energy harvesting devices on living insects,” according to Fukuda.
The ultrathin and flexible organic solar cell, and how it was attached to the insect, proved necessary to ensure freedom of movement. After carefully examining natural cockroach movements, the researchers realized that the abdomen changes shape and portions of the exoskeleton overlap. To accommodate this, they interleaved adhesive and non-adhesive sections onto the films, which allowed them to bend but also stay attached. When thicker solar cell films were tested, or when the films were uniformly attached, the cockroaches took twice as long to run the same distance, and had difficulty righting themselves when on their backs.
Once these components were integrated into the cockroaches, along with wires that stimulate the leg segments, the new cyborgs were tested. The battery was charged with pseudo-sunlight for 30 minutes, and animals were made to turn left and right using the wireless remote control.
“Considering the deformation of the thorax and abdomen during basic locomotion, a hybrid electronic system of rigid and flexible elements in the thorax and ultrasoft devices in the abdomen appears to be an effective design for cyborg cockroaches,” says Fukuda. “Moreover, since abdominal deformation is not unique to cockroaches, our strategy can be adapted to other insects like beetles, or perhaps even flying insects like cicadas in the future.”
Story Source:
Materials provided by RIKEN. Note: Content may be edited for style and length. More

Monitoring and measuring forest ecosystems is a complex challenge because of an existing combination of softwares, collection systems and computing environments that require increasing amounts of energy to power. The University of Maine’s Wireless Sensor Networks (WiSe-Net) laboratory has developed a novel method of using artificial intelligence and machine learning to make monitoring soil moisture more energy and cost efficient — one that could be used to make measuring more efficient across the broad forest ecosystems of Maine and beyond.
Soil moisture is an important variable in forested and agricultural ecosystems alike, particularly under the recent drought conditions of past Maine summers. Despite the robust soil moisture monitoring networks and large, freely available databases, the cost of commercial soil moisture sensors and the power that they use to run can be prohibitive for researchers, foresters, farmers and others tracking the health of the land.
Along with researchers at the University of New Hampshire and University of Vermont, UMaine’s WiSe-Net designed a wireless sensor network that uses artificial intelligence to learn how to be more power efficient in monitoring soil moisture and processing the data. The research was funded by a grant from the National Science Foundation.
“AI can learn from the environment, predict the wireless link quality and incoming solar energy to efficiently use limited energy and make a robust low cost network run longer and more reliably,” says Ali Abedi, principal investigator of the recent study and professor of electrical and computer engineering at the University of Maine.
The software learns over time how to make the best use of available network resources, which helps produce power efficient systems at a lower cost for large scale monitoring compared to the existing industry standards.
WiSe-Net also collaborated with Aaron Weiskittel, director of the Center for Research on Sustainable Forests, to ensure that all hardware and software research is informed by the science and tailored to the research needs.
“Soil moisture is a primary driver of tree growth, but it changes rapidly, both daily as well as seasonally,” Weiskittel says. “We have lacked the ability to monitor effectively at scale. Historically, we used expensive sensors that collected at fixed intervals — every minute, for example — but were not very reliable. A cheaper and more robust sensor with wireless capabilities like this really opens the door for future applications for researchers and practitioners alike.”
The study was published Aug. 9, 2022, in the Springer’s International Journal of Wireless Information Networks.
Although the system designed by the researchers focuses on soil moisture, the same methodology could be extended to other types of sensors, like ambient temperature, snow depth and more, as well as scaling up the networks with more sensor nodes.
“Real-time monitoring of different variables requires different sampling rates and power levels. An AI agent can learn these and adjust the data collection and transmission frequency accordingly rather than sampling and sending every single data point, which is not as efficient,” Abedi says.
Story Source:
Materials provided by University of Maine. Note: Content may be edited for style and length. More