Researchers develop smartphone-powered microchip for at-home medical diagnostic testing
A University of Minnesota Twin Cities research team has developed a new microfluidic chip for diagnosing diseases that uses a minimal number of components and can be powered wirelessly by a smartphone. The innovation opens the door for faster and more affordable at-home medical testing.
The researchers’ paper is published in Nature Communications, a peer-reviewed, open access, scientific journal published by Nature Research. Researchers are also working to commercialize the technology.
Microfluidics involves the study and manipulation of liquids at a very small scale. One of the most popular applications in the field is developing “lab-on-a-chip” technology, or the ability to create devices that can diagnose diseases from a very small biological sample, blood or urine, for example.
Scientists already have portable devices for diagnosing some conditions — rapid COVID-19 antigen tests, for one. However, a big roadblock to engineering more sophisticated diagnostic chips that could, for example, identify the specific strain of COVID-19 or measure biomarkers like glucose or cholesterol, is the fact that they need so many moving parts.
Chips like these would require materials to seal the liquid inside, pumps and tubing to manipulate the liquid, and wires to activate those pumps — all materials that are difficult to scale down to the micro level. Researchers at the University of Minnesota Twin Cities were able to create a microfluidic device that functions without all of those bulky components.
“Researchers have been extremely successful when it comes to electronic device scaling, but the ability to handle liquid samples has not kept up,” said Sang-Hyun Oh, a professor in the University of Minnesota Twin Cities Department of Electrical and Computer Engineering and senior author of the study. “It’s not an exaggeration that a state-of-the-art, microfluidic lab-on-a-chip system is very labor intensive to put together. Our thought was, can we just get rid of the cover material, wires, and pumps altogether and make it simple?”
Many lab-on-a-chip technologies work by moving liquid droplets across a microchip to detect the virus pathogens or bacteria inside the sample. The University of Minnesota researchers’ solution was inspired by a peculiar real-world phenomenon with which wine drinkers will be familiar — the “legs,” or long droplets that form inside a wine bottle due to surface tension caused by the evaporation of alcohol. More