Computers Math

Analysing molecular characteristics and their variation during lifestyle changes, by combining digital tools, classical laboratory tests and new biomolecular measurements, could enable individualised prevention of disease. This is according to a new study from Karolinska Institutet in Sweden and the University of Helsinki in Finland published in the journal Cell Systems. The researchers show what a proactive healthcare model could comprise and how it could help in maintaining good health.
Sensors, apps and other digital alternatives for monitoring health are increasing our ability to take proactive measures to improve our health and wellbeing. Moreover, the simultaneous measurement of numerous biomolecular variables (multiomics) enables deep and comprehensive profiling of human biology.
“Instead of focusing on the treatment of the later stages of disease, future healthcare services could focus on more proactive and individualised interventions and on the early detection of disease,” says the study’s first author Francesco Marabita, researcher at the Department of Oncology-Pathology, Karolinska Institutet and SciLifeLab in Sweden. “It might sound a little futuristic, but the technology is already there.”
The Digital Health Revolution (DHR) project is a multicentre study set up a few years ago by researchers, amongst other institutions, from the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki to explore and pilot future approaches to healthcare.
The study spanned 16 months and included 96 individuals between the ages of 25 and 59 who were registered at an occupational healthcare clinic in Helsinki, Finland. There were no known serious diseases, but some of the participants had risk factors such as high blood pressure, elevated glucose or obesity.
The molecular profiling was done in collaboration with investigators from Karolinska Institutet and SciLifeLab. In addition to extensive multiomics analyses, the serial data collection included online questionnaires, clinical laboratory measurements in blood samples, analysis of the gut microbiome, and activity and sleep data using a smart watch. More

More attention must be paid to improving perceptions of emerging technologies like AI-powered symptom checkers, which could ease the strain on health-care systems, according to a recent study.
Symptom checkers are online platforms that help with self-triage based on a range of inputted symptoms and demographic details.
The study, led by University of Waterloo researchers, found that “tech seekers,” people who are open to technology but perceive a lack of access to it, are the most likely to want to use the technology — more than “tech acceptors,” people who are both open to it and perceive it to be accessible.
The least likely group of people to adopt the tool are “tech rejectors,” those who do not view it as accessible and have a negative view of AI. In between were “skeptics,” who have concerns about trust and output quality, and “unsure acceptors,” who do not perceive access to be an issue but have negative perceptions about AI.
“These findings should be of great interest — or concern — to the three active arms of any health-care system that intends to use AI-driven symptom checkers: prospective patients, medical experts and developers of AI-driven symptom checkers,” said co-author Ashok Chaurasia, a professor in the School of Public Health Sciences. “This study highlights the need for more collaboration between these groups to improve AI models and their perception within the general population and medical experts.”
Stephanie Aboueid, the study’s lead author and a School of Public Health Sciences graduate, said, “This technology is very promising in the health-care sector, given that it has the potential to reduce unnecessary medical visits and address the lack of access to primary care providers.”
The researchers surveyed 1,305 university students aged 18 to 34 who had never used a symptom checker before the study. They gathered data on trust, usefulness, credibility, demonstrability, output quality, perspectives about AI, ease of use and accessibility for the analysis.
“Symptom checkers are important because they speak to the younger generation who value timeliness and convenience,” Aboueid said. “They are not just a fad, as we’ve seen with Babylon, for example, which recently went public and has been adopted by various health institutions.
Aboueid said the researchers used university-aged responders for the study because they are typically eager adopters of technology. Because of the age group studied, high education levels and good health status, additional studies are needed in other populations with wider age ranges, education and health levels, the researchers said.
Story Source:
Materials provided by University of Waterloo. Note: Content may be edited for style and length. More

An analysis of the effect role models have on students’ motivation in studying STEM subjects points to new ways to deploy these leaders in order to encourage learning across different populations. The recommendations provide a resource for parents, teachers, and policymakers seeking to maximize role models’ impact in diversifying the fields of science, technology, engineering, and mathematics.
“STEM fields fail to attract and retain women as well as racial and ethnic minorities in numbers proportional to their share of the population,” explains Andrei Cimpian, a professor in New York University’s Department of Psychology and the senior author of the paper, hich appears in the International Journal of STEM Education. “A popular method to diversify the STEM workforce has been to introduce students to STEM role models, but less clear is how effective this approach is — simply because it’s not certain which role models resonate with different student populations.”
“Our recommendations, based on an analysis of over 50 studies, are aimed at ensuring that STEM role models are motivating for students of all backgrounds and demographics,” adds lead author Jessica Gladstone, an NYU postdoctoral fellow at the time of the study and now a researcher at Virginia Commonwealth University.
Marian Wright Edelman, founder and president emerita of the Children’s Defense Fund, popularized the phrase “You can’t be what you can’t see,” which emphasized the importance of having role models with whom diverse populations could identify.
While many have claimed that exposing students to role models is an effective tool for diversifying STEM fields, the evidence supporting this position is mixed. Moreover, the researchers note, the argument is a vague one, leaving open questions about under what conditions and for which populations role models can be useful for this purpose.
Gladstone and Cimpian sought to bring more clarity to this important issue by reframing the question being asked. Rather than asking “Are role models effective?,” they asked a more specific — and potentially more informative — question: “Which role models are effective for which students?”
In addressing it, they reviewed 55 studies on students’ STEM motivation as a function of several key features of role models — their perceived competence, their perceived similarity to students, and the perceived attainability of their success. They also examined how features of the students themselves, such as their gender, race/ethnicity, age, and identification with STEM, modulate the effectiveness of role models. More

Researchers have found that the physical texture of robots influenced perceptions of robot personality. Furthermore, first impressions of robots, based on physical appearance alone, could influence the relationship between physical texture and robot personality formation. This work could facilitate the development of robots with perceived personalities that match user expectations.
Impressions of a robot’s personality can be influenced by the way it looks, sounds, and feels. But now, researchers from Japan have found specific causal relationships between impressions of robot personality and body texture.
In a study published in Advanced Robotics, researchers from Osaka University and Kanazawa University have revealed that a robot’s physical texture interacts with elements of its appearance in a way that influences impressions of its personality.
Body texture, such as softness or elasticity, is an important consideration in the design of robots meant for interactive functions. In addition, appearance can modulate whether a person anticipates a robot to be friendly, likable, or capable, among other characteristics.
However, the ways in which people perceive the physical texture and the personality of robots have only been examined independently. As a result, the relationships between these two factors is unclear, something the researchers aimed to address.
“The mechanisms of impression formation should be quantitatively and systematically investigated,” says lead author of the study Naoki Umeda. “Because various factors contribute to personality impression, we wanted to investigate how specific robot body properties promote or deteriorate specific kinds of impressions.”
To do this, the researchers asked adult participants to view, touch, and evaluate six different inactive robots that were humanoid to varying degrees. The participants were asked to touch the arm of the robots. For each robot, four fake arms had been constructed; these were made of silicone rubber and prepared in such a way that their elasticity varied, thus providing differing touch sensations. The causal relationships between the physical textures of the robot arms and the participant perceptions were then evaluated.
“The results confirmed our expectations,” explains Hisashi Ishihara, senior author. “We found that the impressions of the personalities of the robots varied according to the texture of the robot arms, and that there were specific relationships among certain parameters.”
The researchers also found that the first impressions of the robots, made before the participants touched them, could modulate one of the effects.
“We found that the impression of likability was strengthened when the participant anticipated that the robot would engage in peaceful emotional verbal communication. This suggests that both first impressions and touch sensations are important considerations for social robot designers focused on perceived robot personality,” says Ishihara.
Given that many robots are designed for physical interaction with humans — for instance those used in therapy or clinical settings — the texture of the robot body is an important consideration. A thorough understanding of the physical factors that influence user impressions of robots will enable researchers to design robots that optimize user comfort. This is especially important for robots employed for advanced communication, because user comfort will influence the quality of communication, and thus the utility of the robotic system.
Story Source:
Materials provided by Osaka University. Note: Content may be edited for style and length. More

A new strategy to reduce the spread of COVID-19 employs a mobile robot that detects people in crowds who are not observing social-distancing rules, navigates to them, and encourages them to move apart. Adarsh Jagan Sathyamoorthy of the University of Maryland, College Park, and colleagues present these findings in the open-access journal PLOS ONE on Dec. 1, 2021.
Previous research has shown that staying at least two meters apart from others can reduce the spread of COVID-19. Technology-based methods — such as strategies using WiFi and Bluetooth — hold promise to help detect and discourage lapses in social distancing. However, many such approaches require participation from individuals or existing infrastructure, so robots have emerged as a potential tool for addressing social distancing in crowds.
Now, Sathyamoorthy and colleagues have developed a novel way to use an autonomous mobile robot for this purpose. The robot can detect breaches and navigate to them using its own Red Green Blue — Depth (RGB-D) camera and 2-D LiDAR (Light Detection and Ranging) sensor, and can tap into an existing CCTV system, if available. Once it reaches the breach, the robot encourages people to move apart via text that appears on a mounted display.
The robot uses a novel system to sort people who have breached social distancing rules into different groups, prioritize them according to whether they are standing still or moving, and then navigate to them. This system employs a machine-learning method known as Deep Reinforcement Learning and Frozone, an algorithm previously developed by several of the same researchers to help robots navigate crowds.
The researchers tested their method by having volunteers act out social-distancing breach scenarios while standing still, walking, or moving erratically. Their robot was able to detect and address most of the breaches that occurred, and CCTV enhanced its performance.
The robot also uses a thermal camera that can detect people with potential fevers, aiding contact-tracing efforts, while also incorporating measures to ensure privacy protection and de-identification.
Further research is needed to validate and refine this method, such as by exploring how the presence of robots impacts people’s behavior in crowds.
The authors add: “A lot of healthcare workers and security personnel had to put their health at risk to serve the public during the COVID-19 pandemic. Our work’s core objective is to provide them with tools to safely and efficiently serve their communities.”
Story Source:
Materials provided by PLOS. Note: Content may be edited for style and length. More

Like snowflakes, no two branches are alike. They can differ in size, shape and texture; some might be wet or moss-covered or bursting with offshoots. And yet birds can land on just about any of them. This ability was of great interest to the labs of Stanford University engineers Mark Cutkosky and David Lentink — now at University of Groningen in the Netherlands — which have both developed technologies inspired by animal abilities.
“It’s not easy to mimic how birds fly and perch,” said William Roderick, PhD ’20, who was a graduate student in both labs. “After millions of years of evolution, they make takeoff and landing look so easy, even among all of the complexity and variability of the tree branches you would find in a forest.”
Years of study on animal-inspired robots in the Cutkosky Lab and on bird-inspired aerial robots in the Lentink Lab enabled the researchers to build their own perching robot, detailed in a paper published Dec. 1 in Science Robotics. When attached to a quadcopter drone, their “stereotyped nature-inspired aerial grasper,” or SNAG, forms a robot that can fly around, catch and carry objects and perch on various surfaces. Showing the potential versatility of this work, the researchers used it to compare different types of bird toe arrangements and to measure microclimates in a remote Oregon forest.
A bird bot in the forest
In the researchers’ previous studies of parrotlets — the second smallest parrot species — the diminutive birds flew back and forth between special perches while being recorded by five high-speed cameras. The perches — representing a variety of sizes and materials, including wood, foam, sandpaper and Teflon — also contained sensors that captured the physical forces associated with the birds’ landings, perching and takeoff.
“What surprised us was that they did the same aerial maneuvers, no matter what surfaces they were landing on,” said Roderick, who is lead author of the paper. “They let the feet handle the variability and complexity of the surface texture itself.” This formulaic behavior seen in every bird landing is why the “S” in SNAG stands for “stereotyped.”
Just like the parrotlets, SNAG approaches every landing in the same way. But, in order to account for the size of the quadcopter, SNAG is based on the legs of a peregrine falcon. In place of bones, it has a 3D-printed structure — which took 20 iterations to perfect — and motors and fishing line stand-in for muscles and tendons. More

Current simulations of cosmic structure formation do not accurately reproduce the properties of ghost-like particles called neutrinos that have been present in the Universe since its beginning. But now, a research team from Japan has devised an approach that solves this problem.
In a study published this month in SC ’21: Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis, researchers at the University of Tsukuba, Kyoto University, and the University of Tokyo report simulations that precisely follow the dynamics of such cosmic relic neutrinos. This study was selected as a finalist for the 2021 ACM Gordon Bell Prize, which recognizes outstanding achievement in high-performance computing.
Neutrinos are much lighter than all other known particles, but their exact mass remains a mystery. Measuring this mass could help scientists develop theories that go beyond the standard model of particle physics and test explanations for how the Universe evolved. One promising way to pin down this mass is to study the impact of cosmic relic neutrinos on large-scale structure formation using simulations and compare the results with observations. But these simulations need to be extremely accurate.
“Standard simulations use techniques known as particle-based N-body methods, which have two main drawbacks when it comes to massive neutrinos,” explains Dr. Naoki Yoshida, Principal Investigator at the Kavli Institute for the Physics and Mathematics of the Universe, the University of Tokyo. “First, the simulation results are susceptible to random fluctuations called shot noise. And second, these particle-based methods cannot accurately reproduce collisionless damping — a key process in which fast-moving neutrinos suppress the growth of structure in the Universe.”
To avoid these issues, the researchers followed the dynamics of the massive neutrinos by directly solving a central equation in plasma physics known as the Vlasov equation. Unlike previous studies, they solved this equation in full six-dimensional phase space, which means that all six dimensions associated with space and velocity were considered. The team coupled this Vlasov simulation with a particle-based N-body simulation of cold dark matter — the main component of matter in the Universe. They performed their hybrid simulations on the supercomputer Fugaku at the RIKEN Center for Computational Science.
“Our largest simulation self-consistently combines the Vlasov simulation on 400 trillion grids with 330 billion-body calculations, and it accurately reproduces the complex dynamics of cosmic neutrinos,” says lead author of the study, Professor Koji Yoshikawa. “Moreover, the time-to-solution for our simulation is substantially shorter than that for the largest N-body simulations, and the performance scales extremely well with up to 147,456 nodes (7 million CPU cores) on Fugaku.”
In addition to helping determine the neutrino mass, the researchers suggest that their scheme could be used to study, for example, phenomena involving electrostatic and magnetized plasma and self-gravitating systems.
Story Source:
Materials provided by University of Tsukuba. Note: Content may be edited for style and length. More

Equilibrium may be hard to achieve in our lives, but it is the standard state of nature.
From the perspective of chemistry and physics, equilibrium is a bit dull — at least to Cheng-Chien Chen, assistant professor of physics at the University of Alabama at Birmingham. His research tries to engineering new states of matter and control these states by probing the possibilities of non-equilibrium.
“One of our main goals is to see if, when we drive the electron system to non-equilibrium, we can stabilize new phases that are absent in equilibrium, but that can become dominant at non-equilibrium,” Chen said. “This is one of the holy grails in non-equilibrium studies.”
Recently, with support from the National Science Foundation (NSF), Chen has been studying the effects of pump probe spectroscopy, which uses ultrashort laser pulses to excite (pump) the electrons in a sample, generating a non-equilibrium state, while a weaker beam (probe) monitors the pump-induced changes.
Chen’s theoretical work suggests it is possible to generate superconductivity at higher temperature than previously possible using this method, opening the door to revolutionary new electronics and energy devices.
Writing in Physical Review Letters in 2018, Chen and collaborator Yao Wang from Clemson University showed that it was possible to generate d-wave superconductivity and make it the dominant phase using pump-probe systems. More