Computers Math

Wearable sensors to monitor everything from step count to heart rate are nearly ubiquitous. But for scenarios such as measuring the onset of frailty in older adults, promptly diagnosing deadly diseases, testing the efficacy of new drugs or tracking the performance of professional athletes, medical-grade devices are needed.
University of Arizona engineers have developed a type of wearable they call a “biosymbiotic device,” which has several unprecedented benefits. Not only are the devices custom 3D-printed and based on body scans of wearers, but they can operate continuously using a combination of wireless power transfer and compact energy storage. The team, led by Philipp Gutruf, assistant professor of biomedical engineering and Craig M. Berge Faculty Fellow in the College of Engineering, published its findings today in the journal Science Advances.
“There’s nothing like this out there,” said Gutruf, a member of the university’s BIO5 Institute. “We introduce a completely new concept of tailoring a device directly to a person and using wireless power casting to allow the device to operate 24/7 without ever needing to recharge.”
Custom Fit Enables Precise Monitoring
Current wearable sensors face various limitations. Smartwatches, for example, need to be charged, and they can only gather limited amounts of data due to their placement on the wrist. By using 3D scans of a wearer’s body, which can be gathered via methods including MRIs, CT scans and even carefully combined smartphone images, Gutruf and his team can 3D-print custom-fitted devices that wrap around various body parts. Think a virtually unnoticeable, lightweight, breathable, mesh cuff designed specifically for your bicep, calf or torso. The ability to specialize sensor placement allows researchers to measure physiological parameters they otherwise couldn’t.
“If you want something close to core body temperature continuously, for example, you’d want to place the sensor in the armpit. Or, if you want to measure the way your bicep deforms during exercise, we can place a sensor in the devices that can accomplish that,” said Tucker Stuart, a doctoral student in biomedical engineering and first author on the paper. “Because of the way we fabricate the device and attach it to the body, we’re able to use it to gather data a traditional, wrist-mounted wearable device wouldn’t be able to collect.”
Because these biosymbiotic devices are custom fitted to the wearer, they’re also highly sensitive. Gutruf’s team tested the device’s ability to monitor parameters including temperature and strain while a person jumped, walked on a treadmill and used a rowing machine. In the rowing machine test, subjects wore multiple devices, tracking exercise intensity and the way muscles deformed with fine detail. The devices were accurate enough to detect body temperature changes induced by walking up a single flight of stairs. More

As the popularity of fitness trackers has increased, so have the opportunities to use such devices to not only track fitness goals but also increase the motivation to meet those goals. Researchers in the College of Engineering and the College of Health and Human Development at Penn State have teamed up to use control systems engineering tools to tailor motivational messages sent to individual device users.
The results of their study were published today (Oct. 7) in Health Psychology.
“One of the really exciting advances of the last 15 years has been the advent of wearable and portable consumer technology that can be used to help promote physical activity,” said David Conroy, professor of kinesiology and human development and family studies, and co-principal investigator on the paper. “You can get real-time feedback from these devices and monitor your goals, and you can even push people messages, depending on what their goals are and what their behavior is. We know that those messages work well for improving behavior on average. But nobody is average, and we don’t know how to make sure each individual consistently gets the greatest benefit from a limited number of messages.”
Conroy said that researchers have tried several strategies, including messages that are specific to certain population segments; messages based on recent behavior — for example, sending one of two different messages depending on if a user did or did not meet their goals the previous day; and customizing the messages by putting in a person’s name or something they might like. So far, none of these approaches has proven to be consistently effective in improving the messages’ effects.
The new messaging approach developed by Conroy and Constantino Lagoa, co-principal investigator and professor of electrical engineering, applies tools used regularly in controlled systems engineering to behavior science.
“Essentially, we’re using the same mathematical tools that people in control engineering usually use to model behaviors as differential equations,” Lagoa said. “We’re using those models to design feedback controllers that take into account the current state of the person and together with the model decide what is the best time to send the messages.”
Conroy emphasized that establishing the correct dosing — meaning the type of message and its timing, frequency and context — is a critical part to this approach. More

Researchers at the Technion’s Rappaport Faculty of Medicine have developed an innovative algorithm that detects an uninterrupted common denominator in multidimensional data gathered from tumors of different patients. The study, which was published in Cell Systems, was led by Professor Shai Shen-Orr, Dr. Yishai Ofran, and Dr. Ayelet Alpert, and conducted in collaboration between researchers at the Technion, the Rambam Health Care Campus, the Shaare Zedek Medical Center and the University of Texas.
In recent years, cancer research has undergone a series of significant revolutions, including the introduction of single-cell high-resolution characterization capabilities, or, more specifically, simultaneous high-throughput profiling of cancer samples using single-cell RNA sequencing and proteomics analysis. This has led to the generation of vast quantities of multidimensional data on a huge number of cells, allowing for the characterization of both the healthy tissue and malignant tissues. This high amount of data has revealed the great variability between tumors of different patients, where cellular characterization that is derived from the patient’s genetic background is unique to each patient.
Despite the substantial advantage that is derived from such an accurate characterization of the specific patient, this development hinders comparison of different patients: in the absence of a common denominator, the comparison, which is essential for identifying prognostic markers (e.g. mortality or severity of illness), becomes impossible.
The tuMap algorithm developed by the Technion researchers provides a solution to this complex challenge by means of a “variance-based comparison.” The innovative algorithm delivers the possibility to place numerous different tumors on a uniform scale that provides a benchmark for comparison. In this way, the tumors of different patients can be meaningfully compared, as well as tumors of the same patient over the disease course (for example, on diagnosis and after treatment). The resolution provided by the algorithm can be leveraged for clinical applications such as prediction of various clinical indices with a very high accuracy, outperforming traditional tools. Although the researchers tested the algorithm on leukemia tumors, they believe that it will also be relevant for other cancer types.
The research was sponsored by the Israel Science Foundation, the Rappaport Family Institute for Research in the Medical Sciences, and the National Institutes of Health (NIH).
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Materials provided by Technion-Israel Institute of Technology. Note: Content may be edited for style and length. More

A study in the journal Physica A leverages concepts from physics to model how campaign strategies influence the opinions of an electorate in a two-party system.
Researchers created a numerical model that describes how external influences, modeled as a random field, shift the views of potential voters as they interact with each other in different political environments.
The model accounts for the behavior of conformists (people whose views align with the views of the majority in a social network); contrarians (people whose views oppose the views of the majority); and inflexibles (people who will not change their opinions).
“The interplay between these behaviors allows us to create electorates with diverse behaviors interacting in environments with different levels of dominance by political parties,” says first author Mukesh Tiwari, PhD, associate professor at the Dhirubhai Ambani Institute of Information and Communication Technology.
“We are able to model the behavior and conflicts of democracies, and capture different types of behavior that we see in elections,” says senior author Surajit Sen, PhD, professor of physics in the University at Buffalo College of Arts and Sciences.
Sen and Tiwari conducted the study with Xiguang Yang, a former UB physics student. Jacob Neiheisel, PhD, associate professor of political science at UB, provided feedback to the team, but was not an author of the research. The study was published online in Physica A in July and will appear in the journal’s Nov. 15 volume. More

Understanding structure-property relations is a key goal of materials research, according to Joshua Agar, a faculty member in Lehigh University’s Department of Materials Science and Engineering. And yet currently no metric exists to understand the structure of materials because of the complexity and multidimensional nature of structure.
Artificial neural networks, a type of machine learning, can be trained to identify similarities?and even correlate parameters such as structure and properties?but there are two major challenges, says Agar. One is that the majority of vast amounts of data generated by materials experiments are never analyzed. This is largely because such images, produced by scientists in laboratories all over the world, are rarely stored in a usable manner and not usually shared with other research teams. The second challenge is that neural networks are not very effective at learning symmetry and periodicity (how periodic a material’s structure is), two features of utmost importance to materials researchers.
Now, a team led by Lehigh University has developed a novel machine learning approach that can create similarity projections via machine learning, enabling researchers to search an unstructured image database for the first time and identify trends. Agar and his collaborators developed and trained a neural network model to include symmetry-aware features and then applied their method to a set of 25,133 piezoresponse force microscopy images collected on diverse materials systems over five years at the University of California, Berkeley. The results: they were able to group similar classes of material together and observe trends, forming a basis by which to start to understand structure-property relationships.
“One of the novelties of our work is that we built a special neural network to understand symmetry and we use that as a feature extractor to make it much better at understanding images,” says Agar, a lead author of the paper where the work is described: “Symmetry-Aware Recursive Image Similarity Exploration for Materials Microscopy,” published today in Nature Computational Materials Science. In addition to Agar, authors include, from Lehigh University: Tri N. M. Nguyen, Yichen Guo, Shuyu Qin and Kylie S. Frew and, from Stanford University: Ruijuan Xu. Nguyen, a lead author, was an undergraduate at Lehigh University and is now pursuing a Ph.D. at Stanford.
The team was able to arrive at projections by employing Uniform Manifold Approximation and Projection (UMAP), a non-linear dimensionality reduction technique. This approach, says Agar, allows researchers to learn .” ..in a fuzzy way, the topology and the higher-level structure of the data and compress it down into 2D.”
“If you train a neural network, the result is a vector, or a set of numbers that is a compact descriptor of the features. Those features help classify things so that some similarity is learned,” says Agar. “What’s produced is still rather large in space, though, because you might have 512 or more different features. So, then you want to compress it into a space that a human can comprehend such as 2D, or 3D?or, maybe, 4D.”
By doing this, Agar and his team were able to take the 25,000-plus images and group very similar classes of material together. More

Polymer science has made possible rubber tires, Teflon and Kevlar, plastic water bottles, nylon jackets among many other ubiquitous features of daily life. Elastic polymers, known as elastomers, can be stretched and released repeatedly and are used in applications such as gloves and heart valves, where they need to last a long time without tearing. But a conundrum has long stumped polymer scientists: Elastic polymers can be stiff, or they can be tough, but they can’t be both.
This stiffness-toughness conflict is a challenge for scientists developing polymers that could be used in applications including tissue regeneration, bioadhesives, bioprinting, wearable electronics, and soft robots.
In a paper published today in Science, researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have resolved that long-standing conflict and developed an elastomer that is both stiff and tough.
“In addition to developing polymers for emerging applications, scientists are facing an urgent challenge: plastic pollution,” said Zhigang Suo, the Allen E. and Marilyn M. Puckett Professor of Mechanics and Materials, the senior author of the study. “The development of biodegradable polymers has once again brought us back to fundamental questions — why are some polymers tough, but others brittle? How do we make polymers resist tearing under repeated stretching?”
Polymer chains are made by linking together monomer building blocks. To make a material elastic , the polymer chains are crosslinked by covalent bonds. The more crosslinks, the shorter the polymer chains and the stiffer the material.
“As your polymer chains become shorter, the energy you can store in the material becomes less and the material becomes brittle,” said Junsoo Kim, a graduate student at SEAS and co-first author of the paper. “If you have only a few crosslinks, the chains are longer, and the material is tough but it’s too squishy to be useful.”
To develop a polymer that is both stiff and tough, the researchers looked to physical, rather than chemical bonds to link the polymer chains. These physical bonds, called entanglements, have been known in the field for almost as long as polymer science has existed, but they’ve been thought to only impact stiffness, not toughness. More

For the first time, researchers have been able capture images providing unprecedented details of how particles behave in a liquid suspension when the phenomenon known as shear thickening takes place. The work allows us to directly understand the processes behind shear thickening, which had previously only been understood based on inference and computational modeling.
Shear thickening is a phenomenon that can occur when particles are suspended in a low-viscosity solution. If the concentration of particles is high enough, then when stress is applied to the solution it becomes very viscous — effectively behaving like a solid. When the stress is removed or dissipates, the suspension returns to its normal fluid-like viscosity. This phenomenon can be seen in popular YouTube videos in which people are able to run across a solution of corn starch suspended in water — but sink into the solution when they stand still.
Shear thickening can be a liability or an advantage, depending on the context.
For example, in industries from food processing to pharmaceutical manufacturing, companies often try to pump liquids with high particle concentrations to make manufacturing processes more efficient and cost-effective. And if those companies don’t properly account for shear thickening, the liquids being pumped can jam or clog — costing them valuable time and potentially damaging their equipment.
On the other hand, the properties of shear thickening can also be used to develop force-absorbing materials for use in applications such as body armor, or as a mechanism for controlling the physical characteristics of soft robotics devices.
For these reasons, researchers have spent years trying to understand precisely how and why shear thickening occurs. However, researchers have been forced to rely on indirect experimentation, because they were unable to capture the precise behavior of the particles in solution as shear thickening takes place. Until now. More

A new study published in one of the world’s leading medical journals has revealed a link between screen time and higher risk and severity of myopia, or short-sightedness, in children and young adults.
The open-access research, published this week in The Lancet Digital Health, was undertaken by researchers and eye health experts from Singapore, Australia, China and the UK, including Professor Rupert Bourne from Anglia Ruskin University (ARU). The authors examined more than 3,000 studies investigating smart device exposure and myopia in children and young adults aged between 3 months old and 33 years old.
After analysing and statistically combining the available studies, the authors revealed that high levels of smart device screen time, such as looking at a mobile phone, is associated with around a 30% higher risk of myopia and, when combined with excessive computer use, that risk rose to around 80%.
The research comes as millions of children around the world have spent substantial time using remote learning methods following the closure of schools due to the COVID-19 pandemic.
Professor Bourne, Professor of Ophthalmology in the Vision and Eye Research Institute at Anglia Ruskin University (ARU), said: “Around half the global population is expected to have myopia by 2050, so it is a health concern that is escalating quickly. Our study is the most comprehensive yet on this issue and shows a potential link between screen time and myopia in young people.
“This research comes at a time when our children have been spending more time than ever looking at screens for long periods, due to school closures, and it is clear that urgent research is needed to further understand how exposure to digital devices can affect our eyes and vision. We also know that people underestimate their own screen time, so future studies should use objective measures to capture this information.”
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Materials provided by Anglia Ruskin University. Note: Content may be edited for style and length. More