Computers Math

Researchers are working with community leaders to develop a mobile alert app to help locate missing people with dementia.
Noelannah Neubauer, a postdoctoral fellow at the University of Waterloo’s School of Public Health Sciences, said “Community ASAP” is aimed at addressing a gap in available tools when it comes to alerts for missing older adults and people living with dementia in Canada.
“We have Amber Alerts for missing children, but nothing for this population other than police and civilians circulating information via social media such as Twitter and Facebook,” said Neubauer, who is the first author of a study that tested the efficacy and useability of Community ASAP.
The U.S. already uses a system called Silver Alert, and there have been efforts in some provinces, such as British Columbia, to create a citizen-led alert system. The issue with piggybacking onto the Amber Alert system is that too many people go missing every day, according to Neubauer. Almost 750,000 Canadians live with dementia, and 60 per cent of them wander at least once, and some repeatedly.
“The sheer number of missing people from this population would mean that alerts would go off multiple times a day in certain jurisdictions, running the risk of significant alert fatigue,” Neubauer said. “Community ASAP gets around this by having people sign up to receive the alert on Android and iOS operating systems and choosing the radius from where the missing person was last seen to their current location. Most missing cases take place one kilometre from the place they were last seen.”
“A key concern is that if someone gets lost and is not found within 24 hours, they have a 50 per cent chance of experiencing serious injury or death,” said Lili Liu, principal investigator, and dean of the Faculty of Health at Waterloo. “We proposed recommendations for community alert systems specific to Canada, such as Community ASAP, at an online national forum on community alert systems for missing older adults last fall.”
For the study, researchers engaged people living with dementia, their care partners, police services, search and rescue organizations and health and social service providers in Ontario, Alberta and British Columbia to develop the alert system that engages community citizens, as volunteers, to look out for people with dementia reported missing.
They went through three iterations of the app and consulted with these stakeholder groups along the way to test its accuracy and useability, walking through scenarios to simulate the events that transpire during a missing person event. In these scenarios, participants assumed the key roles in the Community ASAP system, including the missing person with dementia, care partner, coordinator, and volunteers.
The idea for this app came from Ron Beleno, an entrepreneur with experience caring for his father, who lived with dementia. Beleno is turning Community ASAP into a start-up company, and Liu’s research team continues to work with governments and organizations to coordinate a system that works across the country.
The study, “Mobile alert app to engage community volunteers to help locate missing persons with dementia,” co-authored by Noelannah Neubauer, Christine Daum, Antonio Miguel-Cruz and Lili Liu, all affiliated with the University of Waterloo, was recently published in Plos One. More

A new AI (artificial intelligence) tool is set to enable scientists to more accurately forecast Arctic sea ice conditions months into the future. The improved predictions could underpin new early-warning systems that protect Arctic wildlife and coastal communities from the impacts of sea ice loss.
Published this week (Thursday 26 August) in the journal Nature Communications, an international team of researchers led by British Antarctic Survey (BAS) and The Alan Turing Institute describe how the AI system, IceNet, addresses the challenge of producing accurate Arctic sea ice forecasts for the season ahead — something that has eluded scientists for decades.
Sea ice, a vast layer of frozen sea water that appears at the North and South poles, is notoriously difficult to forecast because of its complex relationship with the atmosphere above and ocean below. The sensitivity of sea ice to increasing temperatures has caused the summer Arctic sea ice area to halve over the past four decades, equivalent to the loss of an area around 25 times the size of Great Britain. These accelerating changes have dramatic consequences for our climate, for Arctic ecosystems, and Indigenous and local communities whose livelihoods are tied to the seasonal sea ice cycle.
IceNet, the AI predictive tool, is almost 95% accurate in predicting whether sea ice will be present two months ahead — better than the leading physics-based model.
Lead author Tom Andersson, Data Scientist at the BAS AI Lab and funded by The Alan Turing Institute, explains: “The Arctic is a region on the frontline of climate change and has seen substantial warming over the last 40 years. IceNet has the potential to fill an urgent gap in forecasting sea ice for Arctic sustainability efforts and runs thousands of times faster than traditional methods.”
Dr Scott Hosking, Principal Investigator, Co-leader of the BAS AI Lab and Senior Research Fellow at The Alan Turing Institute, says: “I’m excited to see how AI is making us rethink how we undertake environmental research. Our new sea ice forecasting framework fuses data from satellite sensors with the output of climate models in ways traditional systems simply couldn’t achieve.”
Unlike conventional forecasting systems that attempt to model the laws of physics directly, the authors designed IceNet based on a concept called deep learning. Through this approach, the model ‘learns’ how sea ice changes from thousands of years of climate simulation data, along with decades of observational data to predict the extent of Arctic sea ice months into the future.
Tom Andersson concludes: “Now we’ve demonstrated that AI can accurately forecast sea ice, our next goal is to develop a daily version of the model and have it running publicly in real-time, just like weather forecasts. This could operate as an early warning system for risks associated with rapid sea ice loss.”
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Genomics, proteomics, metabolomics, transcriptomics — rapid advances in high-throughput biomedical technologies has enabled the collection of data with unprecedented detail from the growing number of omics. But, how best to take advantage of the interactions and complementary information in omics data?
To fully utilize the advances in omics technologies to achieve a more comprehensive understanding of the biological processes underlying human diseases, researchers from Regenstrief Institute and Indiana, Purdue and Tulane Universities have developed and tested MOGONET, a novel multi-omics data analysis algorithm and computational methodology. Integrating data from various omics provides a more holistic view of biological processes underlying human diseases. The creators have made MOGONET open source, free and accessible to all researchers.
In a study published in Nature Communications, the scientists demonstrated that MOGONET, short for Multi-Omics Graph cOnvolutional NETworks, outperforms existing supervised multi-omics integrative analysis approaches of different biomedical classification applications using mRNA expression data, DNA methylation data, and microRNA expression data.
They also determined that MOGONET can identify important omics signatures and biomarkers from different omics data types.
“With MOGONET, our new AI [artificial intelligence] tool, we employ machine learning based on a neural network, to capture complex biological process relationships. We have made the understanding of omics more comprehensive and also are learning more about disease subtypes that biomarkers help us differentiate,” said Regenstrief Institute Research Scientist Kun Huang, PhD, who led the study. “The ultimate goal is to improve disease prognosis and enhance disease-outcome predictions.” A bioinformatician, he credits the diversity of the MOGONET research group, which included computer scientists as well as data scientists and bioinformaticians, with their varying perspectives, as instrumental in its development and success. He serves as director of data sciences and informatics for the Indiana University Precision Health Initiative.
The researchers tested MOGONET on datasets related to o Alzheimer’s disease, gliomas, kidney cancer and breast invasive carcinoma as well as on healthy patient datasets. They determined MOGONET handily outperformed existing supervised multi-omics integration methods.
“Learning and integrating intuitive recognition, MOGONET could generate new biomarker disease candidates,”said study co-author Regenstrief Institute Affiliated Scientist Jie Zhang, PhD, a bioinformatician. “MOGONET also could predict new cancer subtypes, tumor grade and disease progression. It can identify normal brain activity versus Alzheimer’s disease.”
Drs. Huang and Zhang plan to expand this work beyond omics to include imaging data, noting the abundance of brain images for AD and cancer-related pathology images which can teach MOGONET to recognize even cases it had not previously encountered. Both scientists note that following rigorous clinical studies, MOGONET could support improved patient care in many areas.
In addition to Drs. Huang and Zhang, authors of “MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification” are Tongxin Wang, PhD, and Haixu Tang, PhD, of Indiana University, Wei Shao, PhD, of IU School of Medicine; Zhi Huang of IU School of Medicine and Purdue University; and Zhengming Ding, PhD of Tulane University. Dr. Wang worked in Dr. Huang’s laboratory. Dr. Ding, formerly of Indiana University, is an expert in the field of machine learning.
The development and testing of MOGONET was supported by National Institutes of Health grants R01EB025018 and U54AG065181 and the Indiana University Precision Health Initiative.
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Physical activity among young people can be improved by well-designed and delivered online interventions such as ‘exergames’ and smartphone apps, new research shows.
According to a review study carried out at the University of Birmingham, children and young people reacted positively in PE lessons to the use of exergames, which deliver physical activity lessons via games or personalised activities. Changes included increases in physical activity levels, but also improved emotions, attitudes and motivations towards physical activity.
The study, published in Physical Education and Sport Pedagogy is one of the first to examine not only the impact of online interventions on physical behaviours in non-clinical groups of young people but the effects of digital mediums on physical activity knowledge, social development and improving mental health.
The evidence can be used to inform guidance for health and education organisations on how they can design online interventions to reach and engage young people in physical activity.
The authors analysed 26 studies of online interventions for physical activity. They found three main mechanisms at work: gamification, in which participants progress through different levels of achievement; personalisation, in which participants received tailored feedback and rewards based on progress; and information, in which participants received educational material or guidance to encourage behavioural change.
Most of the interventions were focused on gamification or personalisation and the researchers found the majority of studies (70%) reported an increase and/or improvement in outcomes related to physical activity for children and young people who participated in online interventions. Primary school age pupils in particular who participated during PE lessons benefited.
Lead author Dr Victoria Goodyear, in the University of Birmingham’s School of Sport, Exercise and Rehabilitation Science, said: “We find convincing evidence that PE teachers can use online learning to boost attitudes and participation in physical activity among young people, particularly at primary school age. There’s a real opportunity here for the PE profession to lead the way in designing meaningful and effective online exercise opportunities, as well as an opportunity to embed positive approaches to exercise and online games and apps at an early stage.”
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Mantis shrimp pack the strongest punch of any creature in the animal kingdom. Their club-like appendages accelerate faster than a bullet out of a gun and just one strike can knock the arm off a crab or break through a snail shell. These small but mighty crustaceans have been known to take on octopus and win.
How mantis shrimp produce these deadly, ultra-fast movements has long fascinated biologists. Recent advancements in high-speed imaging make it possible to see and measure these strikes but some of the mechanics have not been well understood.
Now, an interdisciplinary team of roboticists, engineers and biologists have modeled the mechanics of the mantis shrimp’s punch and built a robot that mimics the movement. The research sheds light on the biology of these pugnacious crustaceans and paves the way for small but mighty robotic devices.
The research is published in the Proceedings of the National Academy of Sciences.
“We are fascinated by so many remarkable behaviors we see in nature, in particular when these behaviors meet or exceed what can be achieved by human-made devices,” said Robert Wood, the Harry Lewis and Marlyn McGrath Professor of Engineering and Applied Sciences at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and senior author of the paper. “The speed and force of mantis shrimp strikes, for example, are a consequence of a complex underlying mechanism. By constructing a robotic model of a mantis shrimp striking appendage, we are able to study these mechanisms in unprecedented detail.”
Many small organisms — including frogs, chameleons, even some kinds of plants — produce ultra-fast movements by storing elastic energy and rapidly releasing it through a latching mechanism, like a mouse trap. In mantis shrimp, two small structures embedded in the tendons of the muscles called sclerites act as the appendage’s latch. In a typical spring-loaded mechanism, once the physical latch is removed, the spring would immediately release the stored energy. More

It isn’t a matter of one needle puncture. Many children coming through the doors of Children’s Hospital Los Angeles are seen for chronic conditions and often require frequent visits. Painful procedures — like a blood draw or catheter placement — can cause anxiety and fear in patients. Now, a study published in JAMA Network Open shows that virtual reality can decrease pain and anxiety in children undergoing intravenous (IV) catheter placement.
For nearly two decades, Jeffrey I. Gold, PhD, an investigator at The Saban Research Institute of Children’s Hospital Los Angeles, has been investigating the use of virtual reality (VR) as a technique to help children undergoing painful medical procedures. His research shows that the technology can have powerful effects. VR works so well that Children’s Hospital Los Angeles now offers it routinely for blood draws.
“Some patients don’t even realize that their blood is being drawn,” says Dr. Gold, who is also a Professor of Clinical Anesthesiology, Pediatrics, and Psychiatry & Behavioral Sciences at The Keck School of Medicine of USC. “Compare that to a child who is panicking and screaming, and it’s a no-brainer. We want kids to feel safe.”
In his recent publication, Dr. Gold’s team reports the results of a study to test whether VR could prevent pain and distress for patients undergoing peripheral intravenous catheter (PIVC) placement. The game is simple, but requires focus and participation. Patients in one group used VR throughout the procedure, while those in another group received standard of care, which includes simple distraction techniques and the use of a numbing cream. The patients who used VR reported significantly lower levels of pain and anxiety.
“We can actually reduce pain without the use of a medication,” says Dr. Gold. “The mind is incredibly powerful at shifting focus and actually preventing pain from being registered. If we can tap into that, we can make the experience much better for our kids.”
But the story is bigger than that. More

University of South Australia researchers have designed a computer vision system that can automatically detect a tiny baby’s face in a hospital bed and remotely monitor its vital signs from a digital camera with the same accuracy as an electrocardiogram machine.
Using artificial intelligence-based software to detect human faces is now common with adults, but this is the first time that researchers have developed software to reliably detect a premature baby’s face and skin when covered in tubes, clothing, and undergoing phototherapy.
Engineering researchers and a neonatal critical care specialist from UniSA remotely monitored heart and respiratory rates of seven infants in the Neonatal Intensive Care Unit (NICU) at Flinders Medical Centre in Adelaide, using a digital camera.
“Babies in neonatal intensive care can be extra difficult for computers to recognise because their faces and bodies are obscured by tubes and other medical equipment,” says UniSA Professor Javaan Chahl, one of the lead researchers.
“Many premature babies are being treated with phototherapy for jaundice, so they are under bright blue lights, which also makes it challenging for computer vision systems.”
The ‘baby detector’ was developed using a dataset of videos of babies in NICU to reliably detect their skin tone and faces. More

A team of researchers led by Director Rod Ruoff at the Center for Multidimensional Carbon Materials (CMCM) within the Institute for Basic Science (IBS), including graduate students at the Ulsan National Institute of Science and Technology (UNIST), have achieved growth and characterization of large area, single-crystal graphene that has no wrinkles, folds, or adlayers. It can be said to be the most perfect graphene that has been grown and characterized, to date.
Director Ruoff notes, “This pioneering breakthrough was due to many contributing factors, including human ingenuity and the ability of the CMCM researchers to reproducibly make large-area single-crystal Cu-Ni(111) foils, on which the graphene was grown by chemical vapor deposition (CVD) using a mixture of ethylene with hydrogen in a stream of argon gas.” Student Meihui Wang, Dr. Ming Huang, and Dr. Da Luo along with Ruoff undertook a series of experiments of growing single-crystal and single-layer graphene on such ‘home-made’ Cu-Ni(111) foils under different temperatures.
The team had previously reported single-crystal and adlayer-free films of graphene which were grown using methane at temperatures of ~1320 Kelvin (K) degrees on Cu(111) foils. Adlayers refer to small “islands” of regions that have another layer of graphene present. However, these films always contained long “folds” that are the consequence of tall wrinkles that form as the graphene is cooled from the growth temperature down to room temperature. This results in an undesirable reduction in the performance of graphene field effect transistor (GFET) if the “fold” is in the active region of the GFET. The folds also contain “cracks” that lower the mechanical strength of the graphene.
The next exciting challenge was thus eliminating these folds.
CMCM researchers first implemented a series of ‘cycling’ experiments that involved “cycling” the temperature immediately after growing the graphene at 1320 K. These experiments showed that the folds are formed at or above 1020 K during the cooling process. After learning this, the team decided to grow graphene on Cu-Ni(111) foils at several different temperatures around 1020 K, which led to a discovery that large-area, high-quality, fold-free, and adlayer-free single-crystal graphene films can be grown in a temperature range between 1000 K and 1030 K. “This fold-free graphene film forms as a single crystal over the entire growth substrate because it shows a single orientation over a large-area low-energy electron diffraction (LEED) patterns,” noted SEONG Won Kyung, a senior research fellow in CMCM who installed the LEED equipment in the center. GFETs were then patterned on this single-crystal fold-free graphene in a variety of directions by UNIST graduate student Yunqing Li. These GFETs showed remarkably uniform performance with average room temperature electron and hole mobilities of 7.0 ± 1.0 × 103 cm2 V-1 s-1. Li notes, “Such remarkably uniform performance is possible because the fold-free graphene film is a single crystal with essentially no imperfections.”
Importantly, the research team was able to achieve “scaling up” of graphene production using this method. The graphene was successfully grown on 5 foils (dimension 4 cm x 7 cm) simultaneously in a 6-inch diameter home-built quartz furnace. “Our method of growing fold-free graphene films is very reproducible, with each foil yielding two identical pieces of high-quality graphene films on both sides of the foil,” and “By using the electrochemical bubbling transfer method, graphene can be delaminated in about 1 minute and the Cu-Ni(111) foil can be quickly readied for the next growth/transfer cycle,” notes Meihui Wang. Ming Huang adds, “When we tested the weight loss of Cu-Ni(111) foils after 5 runs of growth and transfers, the net loss was only 0.0001 grams. This means that our growth and transfer methods using the Cu-Ni(111) can be performed repeatedly, essentially indefinitely.”
In the process of achieving fold-free single-crystal graphene, the researchers also discovered the reasons behind the formation of these folds. High-resolution TEM imaging was performed by student CHOE Myeonggi and Prof. LEE Zonghoon (a group leader in CMCM and professor at UNIST) to observe the cross-sections of the samples grown above 1040 K. They discovered that the deadhesion, which is the cause of the folds, is initiated at the “bunched step edge” regions between the single crystal Cu-Ni(111) plateaus. “This deadhesion at the bunched step edge regions triggers the formation of graphene folds perpendicular to the step edge direction,” noted co-corresponding author Luo. Ruoff further notes that “We discovered that step-bunching of a Cu-Ni(111) foil surface suddenly occurs at about 1030 K, and this ‘surface reconstruction’ is the reason why the critical growth temperature of fold-free graphene is at ~1030 K or below.”
Such large-area fold-free single-crystal graphene film allows for the straightforward fabrication of integrated high-performance devices oriented in any direction over the entire graphene film. These single-crystal graphene films will be important for further advances in basic science, which will lead to new applications in electronic, photonic, mechanical, thermal, and other areas. The near-perfect graphene is also useful for stacking, either with itself and/or with other 2D materials, to further expand the range of likely applications. Given that the Cu-Ni(111) foils can be used repeatedly and that the graphene can be transferred to other substrates in less than one minute, the scalable manufacturing using this process is also highly promising.
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